supported by the National Key Research and Development Program of China,No.2018YFA0108602;the CAMS Initiative for Innovative Medicine,No.2021-1-I2M-019;National High-Level Hospital Clinical Research Funding,No.2022-PUMCH-C-042(all to XB)。
Ischemic stroke is a significant global health crisis,frequently resulting in disability or death,with limited therapeutic interventions available.Although various intrinsic reparative processes are initiated within t...
supported by Qingdao Key Medical and Health Discipline Project;The Intramural Research Program of the Affiliated Hospital of Qingdao University,No. 4910;Qingdao West Coast New Area Science and Technology Project,No. 2020-55 (all to SW)。
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro...
supported by FATALSDrug Project [Progetti di Ricerca@CNR SAC.AD002.173.058] from National Research Council,Italy (to CV)。
The NSC-34 cell line is a widely recognized motor neuron model and various neuronal differentiation protocols have been exploited. Under previously reported experimental conditions, only part of the cells resemble dif...
supported by the National Natural Science Foundation of China,Nos.82072165 and 82272256(both to XM);the Key Project of Xiangyang Central Hospital,No.2023YZ03(to RM)。
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in s...
supported by the National Natural Science Foundation of China,Nos. 82173806 and U1803281;Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science,Nos. 2021-I2M-1-030 and 2022-I2M-2-002;Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences,No. 2022-JKCS-08 (all to RL)。
Long noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer's disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated. The lon...
supported by Technological Innovation 2030-Major Projects of“Brain Science and Brain-like Research,”No.2022ZD0206200(to XG);the National Natural Science Foundation of China,No.82371245(to SJ),82102246(to XD),81701092(to XG);the Natural Science Foundation of Shandong Province,No.ZR2020MH129(to SJ);Shanghai Municipal Key Clinical Specialty,No.shslczdzk03601;Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation,No.20DZ2254200。
Adult hippocampal neurogenesis is linked to memory formation in the adult brain,with new neurons in the hippocampus exhibiting greater plasticity during their immature stages compared to mature neurons.Abnormal adult ...
supported by the Natural Science Foundation of Chongqing,No.CSTB2023NSCQ-mSX0561(to WL).
Effective treatment methods for stroke,a common cerebrovascular disease with a high mortality rate,are still being sought.Exosome therapy,a form of acellular therapy,has demonstrated promising efficacy in various dise...
Recurrent aphthous stomatitis(RAS)is a very frequent condition in developed countries whose basic symptom is a lesion referred to as an aphthous ulcer.High levels of interleukin(IL)-1 and IL-6 and low salivary levels ...
Clinical inertia(CI)is common in clinical practice.Sexual health issues are common in society,and CI is ubiquitous in sexual medicine practice.CI influences all aspects of healthcare,including prevention,diagnosis,and...
Conventional echocardiography can sometimes pose a challenge to diagnosis due to sub-optimal images.Ultrasound contrast agents(UCAs)have been shown to drastically enhance imaging quality,particularly depicting the lef...