MICROGLIA

作品数：613被引量：2214H指数：19
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相关领域：医药卫生更多>>
相关作者：刘松杜泽英李晓玉胡金家孙晋渊更多>>
相关机构：上海交通大学医学院附属新华医院复旦大学中国科学院上海交通大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Optogenetic approaches for neural tissue regeneration:A review of basic optogenetic principles and target cells for therapy
《Neural Regeneration Research》2026年第2期521-533,共13页Davletshin Eldar Sufianov Albert Ageeva Tatyana Sufianova Galina Rizvanov Albert Mukhamedshina Yana 
supported by a grant from the Russian Science Foundation,No.23-75-10041(to MY)。
Optogenetics has revolutionized the field of neuroscience by enabling precise control of neural activity through light-sensitive proteins known as opsins.This review article discusses the fundamental principles of opt...
关键词：adeno-associated virus ASTROCYTES bioluminescent optogenetics channelrhodopsins halorhodopsins MICROGLIA neural stem cells NEURONS OLIGODENDROCYTE OPTOGENETICS 
Microglial intervention in ischemic stroke:Roles and intervention strategies
《Neural Regeneration Research》2026年第2期443-454,共12页Cuiling Ji Lixinbei Sheng Kaijun Han Ping Yuan Wei Li Lu Chen Yongyue Gao 
supported by the National Natural Science Foundation of China,82471345(to LC);the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...
关键词：blood-brain barrier ischemic stroke MICROGLIA nerve regeneration NEUROINFLAMMATION NEUROPROTECTION oxidative stress polarization signaling pathways therapeutic strategies 
Polysialic acid-Siglec immune checkpoints of microglia and macrophages:Perspectives for therapeutic intervention
《Neural Regeneration Research》2026年第2期661-662,共2页Hauke Thiesler Herbert Hildebrandt 
Deutsche Forschungsgemeinschaft(DFG,German Research Foundation),project numbers 324633948 and 409784463(DFG grants Hi 678/9-3 and Hi 678/10-2,FOR2953)to HH;Bundesministerium für Bildung und Forschung-BMBF,project number 16LW0463K to HT.
Microglia are the resident macrophages of the central nervous system.They act as the first line of defense against pathogens and play essential roles in neuroinflammation and tissue repair after brain insult or in neu...
关键词：therapeutic intervention central nervous system immune checkpoints neurodegenerative demyelinating diseases borst MACROPHAGES polysialic acid SIGLEC MICROGLIA 
Fat mass and obesity-mediated N^(6)-methyladenosine modification modulates neuroinflammatory responses after traumatic brain injury
《Neural Regeneration Research》2026年第2期730-741,共12页Xiangrong Chen Jinqing Lai Zhe Wu Jianlong Chen Baoya Yang Chunnuan Chen Chenyu Ding 
supported by grants from the Major Projects of Health Science Research Foundation for Middle-Aged and Young Scientist of Fujian Province,China,No.2022ZQNZD01010010;the National Natural Science Foundation of China,No.82371390;Fujian Province Scientific Foundation,No.2023J01725(all to XC).
The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury.The post-transcriptional modification of N^(6)-methyladenosine is ubiqui...
关键词：ADAM17 epigenetic modification fat mass and obesity N6-methyladenosine MICROGLIA mRNA nerve injury NEUROINFLAMMATION traumatic brain injury tumor necrosis factorα 
Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus
《Neural Regeneration Research》2026年第2期769-779,共11页Baocheng Gao Haoxiang Wang Shuang Hu Kunhong Zhong Xiaoyin Liu Ziang Deng Yuanyou Li Aiping Tong Liangxue Zhou 
supported by the National Natural Science Foundation of China,Nos.82473334(to LZ),82401629(to XL);the Major Scientific and Technological Achievements Transformation Project of Ningxia Hui Autonomous Region,No.2022CJE09013(to LZ);Mianyang Science and Technology Bureau(Mianyang Science and Technology Program),No.2023ZYDF097(to LZ);NHC Key Laboratory of Nuclear Technology Medical Transformation(Mianyang Central Hospital),No.2023HYX001(to LZ);Spinal Cord Diseases Clinical Medical Center of Yunnan Province,No.2024JSKFKT-16(to BG);the Natural Science Foundation of Sichuan Province,No.2024NSFSC1646(to XL);the China Postdoctoral Science Foundation,Nos.GZC20231811(to XL),2024T170601(to XL)and 2024M76228(to XL).
Neural stem cells(NSCs)have the potential for self-renewal and multidirectional differentiation,and their transplantation has achieved good efficacy in a variety of diseases.However,only 1%-10%of transplanted NSCs sur...
关键词：ANGIOGENESIS cerebrospinal fluid hippocampal transplantation inflammation MICROGLIA neural stem cells NEUROGENESIS posthemorrhagic hydrocephalus retinoic acid ^(Sox2) 
A single-cell landscape of the regenerating spinal cord of zebrafish
《Neural Regeneration Research》2026年第2期780-789,共10页Lei Yao Xinyi Cai Saishuai Yang Yixing Song Lingyan Xing Guicai Li Zhiming Cui Jiajia Chen 
supported by the Jiangsu Province Traditional Chinese Medicine Technology Development Plan Project,Nos.MS2023113(to JC),MS2022090;Young and Middle-aged Academic Leaders of Jiangsu Qing-Lan Project(to GL).
Unlike mammals,zebrafish possess a remarkable ability to regenerate their spinal cord after injury,making them an ideal vertebrate model for studying regeneration.While previous research has identified key cell types ...
关键词：dividing oligodendrocyte macrophage MICROGLIA neuron proliferating oligodendrocyte radial glia single cell sequencing spinal cord regeneration transcriptome ZEBRAFISH 
Mesenchymal stem cell-derived small extracellular vesicles enhance the therapeutic effect of retinal progenitor cells in retinal degenerative disease rats
《Neural Regeneration Research》2026年第2期821-832,共12页Chunge Ren Min Chen Bangqi Ren Yuxiao Zeng Qiang Tan Qiyou Li Xue Zhang Yajie Fang Yixiao Zhou Weitao Zhang Fang Chen Baishijiao Bian Yong Liu 
supported by the National Natural Science Foundation of China,Nos.82271132(to YL),82101167(to BB);the Natural Science Foundation of Chongqing,Nos.CSTB2022NSCQ-MSX0020(to BB),cstc2019jcyj-msxmX0473(to FC).
Our previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplanta...
关键词：DIFFERENTIATION inflammation mesenchymal stem cells MICROGLIA migration rat retinal degeneration retinal progenitor cells small extracellular vesicles stem cell transplantation 
Microglial polarization pathways and therapeutic drugs targeting activated microglia in traumatic brain injury
《Neural Regeneration Research》2026年第1期39-56,共18页Liping Shi Shuyi Liu Jialing Chen Hong Wang Zhengbo Wang 
supported by the Natural Science Foundation of Yunnan Province,No.202401AS070086(to ZW);the National Key Research and Development Program of China,No.2018YFA0801403(to ZW);Yunnan Science and Technology Talent and Platform Plan,No.202105AC160041(to ZW);the Natural Science Foundation of China,No.31960120(to ZW)。
Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microgl...
关键词：animal model anti-inflammatory drug cell replacement strategy central nervous system mesenchymal stem cell MICROGLIA NEUROINFLAMMATION non-human primate signaling pathway traumatic brain injury 
Hidden face of Parkinson's disease:Is it a new autoimmune disease?
《Neural Regeneration Research》2026年第1期57-61,共5页Min Gi Jo Seon-Hee Kim Seung Pil Yun 
supported by the National Research Foundation of South Korea(2023R1A2C2004516,RS-2023-00219399 to SPY,and 2022R1I1A1A01063513 to MGJ)。
Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease is the ac...
关键词：ASTROCYTE autoimmune response biomarkers clinical implication major histocompatibility complex/human leukocyte antigen MICROGLIA neurodegenerative disease NEUROINFLAMMATION Parkinson's disease T cells Α-SYNUCLEIN 
Emerging role of microglia in the developing dopaminergic system:Perturbation by early life stress
《Neural Regeneration Research》2026年第1期126-140,共15页Kaijie She Naijun Yuan Minyi Huang Wenjun Zhu Manshi Tang Qingyu Ma Jiaxu Chen 
supported by the National Natural Science Foundation of China,Nos.82304990(to NY),81973748(to JC),82174278(to JC);the National Key R&D Program of China,No.2023YFE0209500(to JC);China Postdoctoral Science Foundation,No.2023M732380(to NY);Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine,No.202102010014(to JC);Huang Zhendong Research Fund for Traditional Chinese Medicine of Jinan University,No.201911(to JC);National Innovation and Entrepreneurship Training Program for Undergraduates in China,No.202310559128(to NY and QM);Innovation and Entrepreneurship Training Program for Undergraduates at Jinan University,Nos.CX24380,CX24381(both to NY and QM)。
Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily inv...
关键词：Chinese herbal drugs dopamine early life stress epigenetics gut-brain axis hypothalamo–pituitary–adrenal axis innate immune memory MICROGLIA neuroinflammation Parkinson disease PHAGOCYTOSIS REWARD 
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