OPTOGENETICS

作品数：74被引量：138H指数：7
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相关领域：医药卫生生物学更多>>
相关作者：黄志力王立平更多>>
相关机构：上海医学院香港理工大学中国科学院南洋理工大学更多>>
相关期刊：《National Science Review》《Engineering》《Journal of Innovative Optical Health Sciences》《aBIOTECH》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划以色列科学基金中国博士后科学基金更多>>
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Neural circuit mechanisms of epilepsy:Maintenance of homeostasis at the cellular,synaptic,and neurotransmitter levels
《Neural Regeneration Research》2026年第2期455-465,共11页Xueqing Du Yi Wang Xuefeng Wang Xin Tian Wei Jing 
supported by Basic Research Programs of Science and Technology Commission Foundation of Shanxi Province,No.20210302123486(to WJ).
Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at th...
关键词：chemical genetics hippocampus literature review neural circuits NEUROTRANSMITTER OPTOGENETICS pathogenesis SEIZURE synapses THALAMUS 
Optogenetic approaches for neural tissue regeneration:A review of basic optogenetic principles and target cells for therapy
《Neural Regeneration Research》2026年第2期521-533,共13页Davletshin Eldar Sufianov Albert Ageeva Tatyana Sufianova Galina Rizvanov Albert Mukhamedshina Yana 
supported by a grant from the Russian Science Foundation,No.23-75-10041(to MY)。
Optogenetics has revolutionized the field of neuroscience by enabling precise control of neural activity through light-sensitive proteins known as opsins.This review article discusses the fundamental principles of opt...
关键词：adeno-associated virus ASTROCYTES bioluminescent optogenetics channelrhodopsins halorhodopsins MICROGLIA neural stem cells NEURONS OLIGODENDROCYTE OPTOGENETICS 
Photo-controllable multiple and orthogonal regulation of gene expression by chemically modified oligonucleotides
《Science China Chemistry》2025年第2期694-704,共11页Yang Wang Qiu-Long Zhang Yan Liu Liang-Liang Wang Chao-Qun Wu Ming Shao Xiwen Xing Juan Du Liang Xu 
supported by the National Natural Science Foundation of China(22222706,22307107,22477144);the National Key R&D Program of China(2020YFA0211200);the Guangdong Basic Research Center of Excellence(GBRCE)for Functional Molecular Engineering and the Guangdong Basic and Applied Basic Research Foundation(2024B1515040028)。
Gene expression must be precisely regulated in cells and functional nucleic acids are the most widely utilized tools for gene manipulation.Photocontrol of how these nucleic acid tools work in the cellular environment ...
关键词：functional nucleic acids OPTOGENETICS modified oligonucleotides gene technology 
Locally producing antibacterial peptide to deplete intratumoral pathogen for preventing metastatic breast cancer
《Acta Pharmaceutica Sinica B》2025年第2期1084-1097,共14页Shizhen Geng Tingting Xiang Yaru Shi Mengnian Cao Danyu Wang Jing Wang Xinling Li Haiwei Song Zhenzhong Zhang Jinjin Shi Junjie Liu Airong Li Ke Sun 
supported by the National Natural Science Foundation of China(82172762,21904119,and 82073395);Science and technology innovation talents support project of Henan Province(23HASTIT041);Henan Science Fund for Outstanding Young Scholars(232300421051,China).
Metastatic dissemination is the major cause of death from breast-cancer(BC).Fusobacterium nucleatum(F.n)is widely enriched in BC and has recently been identified as one of the high-risk factors for promoting BC metast...
关键词：Intratumoral pathogen METASTASIS Antibacterial peptide OPTOGENETICS Breast cancer Fusobacterium nucleatum Cancer-associated fibroblast Mild heat 
Optical-neural Stimulation in Non-human Primates:Modulating Brain Function and Behavior
《生物化学与生物物理进展》2024年第10期2379-2391,共13页CHEN Yi-Bing WANG Huan YANG Yan 
国家重点研发计划(2022YFB4700101);科技创新2030-“脑科学与类脑研究”重大项目(2022ZD0204800);国家自然科学基金(32070987)资助。
Optical-neural stimulation,which encompasses cutting-edge techniques such as optogenetics and infrared neurostimulation,employs distinct mechanisms to modulate brain function and behavior.These advanced neuromodulatio...
关键词：optical-neural stimulation OPTOGENETICS infrared neurostimulation non-human primates 
Morphological Tracing and Functional Identification of Monosynaptic Connections in the Brain:A Comprehensive Guide
《Neuroscience Bulletin》2024年第9期1364-1378,共15页Yuanyuan Li Yuanyuan Fang Kaiyuan Li Hongbin Yang Shumin Duan Li Sun 
National Key Research and Development Program of China(2022YFC2402703);Scientific and Technological Innovation 2030 Program of China,major projects(2021ZD0200408);National Natural Science Foundation of China(32171007 and 31800880);Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2018PT31041);Science and Technology Planning Project of Guangdong Province(2018B030331001);Fundamental Research Funds for the Central Universities(K20210089).
Behavioral studies play a crucial role in unraveling the mechanisms underlying brain function.Recent advances in optogenetics,neuronal typing and labeling,and circuit tracing have facilitated the dissection of the neu...
关键词：Trans-monosynaptic RETROGRADE ANTEROGRADE Viral tool Neural circuit OPTOGENETICS ELECTROPHYSIOLOGY 
Optogenetics in oral and craniofacial research
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第8期656-671,共16页Qinmeng ZHANG Luyao SONG Mengdie FU Jin HE Guoli YANG Zhiwei JIANG 
supported by the National Natural Science Foundation of China(No.82370991);the Health Department of Zhejiang Province(Nos.2021KY194 and 2022KY872),China.
Optogenetics combines optics and genetic engineering to control specific gene expression and biological functions and has the advantages of precise spatiotemporal control,noninvasiveness,and high efficiency.Geneticall...
关键词：LASERS Cell differentiation Bacterial virulence Nervous system NEUROPHYSIOLOGY Behavioral science 
Tetherless Optical Neuromodulation:Wavelength from Orange-red to Mid-infrared被引量：1
《Neuroscience Bulletin》2024年第8期1173-1188,共16页Chao Sun Qi Fan Rougang Xie Ceng Luo Bingliang Hu Quan Wang 
supported by China Postdoctoral Science Foundation(2022M723356),"From 0 to 1"Original Innovation Project of the Basic Frontier Scientific Research Program of the Chinese Academy of Sciences(29J20-015-Ⅲ);Chinese Academy of Sciences 100 Talents Project:Research on Task oriented Functional Brain Development of Infants(29J20-052-Ⅲ);Natural Science Basic Research Plan in Shaanxi Province of China(2022JQ544).
Optogenetics,a technique that employs light for neuromodulation,has revolutionized the study of neural mechanisms and the treatment of neurological disorders due to its high spatiotemporal resolution and cell-type spe...
关键词：Optical neuromodulation Tetherless Orange-red wavelength responding rhodopsins Upconversion nanoparticle-mediated optogenetics Photothermal neuromodulation 
Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer’s disease models
《Translational Neurodegeneration》2024年第1期200-214,共15页Saige K.Power Sridevi Venkatesan Sarah Qu JoAnne McLaurin Evelyn K.Lambe 
funded by research grants from the Canadian Institutes of Health(CIHR):MOP 89825,EKL;PRJ153101,EKL and JM;support of a CIHR Banting and Best Canada Graduate Scholarship and an Ontario Graduate Scholarship,SKP.
Background Cognitive reserve allows for resilience to neuropathology,potentially through active compensation.Here,we examine ex vivo electrophysiological evidence for active compensation in Alzheimer’s disease(AD)foc...
关键词：Alzheimer’s disease Cognitive reserve Prefrontal cortex ACETYLCHOLINE Nicotinic receptors OPTOGENETICS ELECTROPHYSIOLOGY Acetylcholinesterase inhibitor Compensation 
Bioinspired nanotransducers for neuromodulation被引量：1
《Nano Research》2024年第2期618-632,共15页Fan Yang Xiang Wu Sa Cai Guosong Hong 
The field of neuromodulation has experienced significant advancements in the past decade,owing to breakthroughs in disciplines such as materials science,genetics,bioengineering,photonics,and beyond.The convergence of ...
关键词：bioinspired synthesis NEUROMODULATION MECHANOLUMINESCENCE focused ultrasound nanotransducers sono-optogenetics 
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