Tetherless Optical Neuromodulation:Wavelength from Orange-red to Mid-infrared  

作　　者：Chao Sun Qi Fan Rougang Xie Ceng Luo Bingliang Hu Quan Wang 

机构地区：[1]Key Laboratory of Spectral Imaging Technology,Xi'an Institute of Optics and Precision Mechanics(XIOPM),Chinese Academy of Sciences,Xi'an 710119,China [2]Key Laboratory of Biomedical Spectroscopy of Xi'an,Key Laboratory of Spectral Imaging Technology,XIOPM,Chinese Academy of Sciences,Xi'an 710119,China [3]Department of Neurobiology,School of Basic Medicine,Fourth Military Medical University,Xi'an 710032,China

出　　处：《Neuroscience Bulletin》2024年第8期1173-1188,共16页神经科学通报（英文版）

基　　金：supported by China Postdoctoral Science Foundation(2022M723356),"From 0 to 1"Original Innovation Project of the Basic Frontier Scientific Research Program of the Chinese Academy of Sciences(29J20-015-Ⅲ);Chinese Academy of Sciences 100 Talents Project:Research on Task oriented Functional Brain Development of Infants(29J20-052-Ⅲ);Natural Science Basic Research Plan in Shaanxi Province of China(2022JQ544).

摘　　要：Optogenetics,a technique that employs light for neuromodulation,has revolutionized the study of neural mechanisms and the treatment of neurological disorders due to its high spatiotemporal resolution and cell-type specificity.However,visible light,particularly blue and green light,commonly used in conventional optogenetics,has limited penetration in biological tissue.This limitation necessitates the implantation of optical fibers for light delivery,especially in deep brain regions,leading to tissue damage and experimental constraints.To overcome these challenges,the use of orange-red and infrared light with greater tissue penetration has emerged as a promising approach for tetherless optical neuromodulation.In this review,we provide an overview of the development and applications of tetherless optical neuromodulation methods with long wavelengths.We first discuss the exploration of orange-red wavelength-responsive rhodopsins and their performance in tetherless optical neuromodulation.Then,we summarize two novel tetherless neuromodulation methods using near-infrared light:upconversion nanoparticle-mediated optogenetics and photothermal neuromodulation.In addition,we discuss recent advances in mid-infrared optical neuromodulation.

关 键 词：Optical neuromodulation Tetherless Orange-red wavelength responding rhodopsins Upconversion nanoparticle-mediated optogenetics Photothermal neuromodulation 

分 类 号：R745[医药卫生—神经病学与精神病学]