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医药卫生—神经病学与精神病学: 作品数：643321被引量：954471H指数：200; 导出分析报告; 相关作者：王拥军陈生弟贾建平樊东升吕佩源更多>>; 相关机构：复旦大学华中科技大学首都医科大学宣武医院中南大学更多>>; 发文主题：脑梗死精神分裂症脑卒中急性脑梗死抑郁症更多>>; 相关期刊：更多>>; 发文基金：国家自然科学基金国家重点基础研究发展计划国家科技支撑计划广东省自然科学基金更多>>

Optogenetic approaches for neural tissue regeneration:A review of basic optogenetic principles and target cells for therapy: 《Neural Regeneration Research》2026年第2期521-533,共13页Davletshin Eldar Sufianov Albert Ageeva Tatyana Sufianova Galina Rizvanov Albert Mukhamedshina Yana; supported by a grant from the Russian Science Foundation,No.23-75-10041(to MY)。; Optogenetics has revolutionized the field of neuroscience by enabling precise control of neural activity through light-sensitive proteins known as opsins.This review article discusses the fundamental principles of opt...; 关键词：adeno-associated virus ASTROCYTES bioluminescent optogenetics channelrhodopsins halorhodopsins MICROGLIA neural stem cells NEURONS OLIGODENDROCYTE OPTOGENETICS

Measuring glymphatic function:Assessing the toolkit: 《Neural Regeneration Research》2026年第2期534-541,共8页Koushikk Ayyappan Lucas Unger Philip Kitchen Roslyn MBill Mootaz MSalman; supported by the European Union Horizon 2020 Research and Innovation Programme(Marie Skłodowska-Curie grant agreement No 847419);supported by the Biotechnology and Biological Sciences Research Council via a Discovery Fellowship(BB/W00934X/1);the Aston University RKE Pump Priming Programme;funded by UKRI’s Research England as part of their Expanding Excellence in England(E3)fund;supported by a UKRI Frontier Research Grant EP/Y023684/1(following assessment as an ERC Advanced grant,FORTIFY,ERC-2022-ADG-101096882 under the UK Government Guarantee scheme)and acknowledged a Biotechnology and Biological Sciences Research Council Pioneer Award(BB/Y512874/1).MMS was supported by a Medical Research Council Career Development Award(MR/W027119/1);acknowledged support from the BHF Centre of Research Excellence,University of Oxford(grant code:RE/24/130024);a Biotechnology and Biological Sciences Research Council Pioneer Award(BB/Y512874/1).; Glymphatic flow has been proposed to clear brain waste while we sleep.Cerebrospinal fluid moves from periarterial to perivenous spaces through the parenchyma,with subsequent cerebrospinal fluid drainage to dural lymph...; 关键词：AQUAPORIN-4 cerebrospinal fluid EFFLUX glymphatics imaging INFLUX methods microfluidics PARENCHYMA periarterial perivenous TRACER

Sesquiterpene lactones as potential drugs treating nerve injury: 《Neural Regeneration Research》2026年第2期671-672,共2页Philipp Gobrecht Marco Leibinger Dietmar Fischer; supported by The German Research Foundation.; Traumatic axonal lesions of peripheral nerves disrupt neuronal connections with their targets,resulting in the loss of motor and sensory functions.Despite the peripheral nervous system’s capacity for axonal regrowth,...; 关键词：traumatic axonal lesions peripheral nervous system s axonal regrowththis permanent impairements nerve injury peripheral nerves disrupt neuronal connections sesquiterpene lactones

Stress signaling caused by mitochondrial import malfunction can be terminated by SIFI:Importance of stress response silencing: 《Neural Regeneration Research》2026年第2期673-674,共2页Grace Hohman Michael Shahid Mohamed A.Eldeeb; Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et a...; 关键词：activation stress pathways neurodegenerative disorders protein aggregatesmitochondrial import stress stress signaling protein aggregates goiran protein aggregates protein aggr neurodegenerative diseasesincluding

p21 as an essential regulator of neurogenic homeostasis in neuropathological conditions: 《Neural Regeneration Research》2026年第2期675-676,共2页Valentina Mastrorilli Stefano Farioli-Vecchioli; supported by PRIN/MUR funding(to VM).; Adult neurogenesis is a highly dynamic process that leads to the production of new neurons from a population of quiescent neural stem cells(NSCs).In response to specific endogenous and/or external stimuli,NSCs enter a...; 关键词：adult neurogenesis quiescent neural stem cells nscs precise molecular pathways mitotic activationinitiating cellular changes neurogenic homeostasis neural progenitorswhich production new neurons

Utilizing Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)in hypothesis-driven queries: 《Neural Regeneration Research》2026年第2期677-678,共2页Diana Acosta Cankun Wang Qin Ma Hongjun Fu; Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other...; 关键词：sex specific alzheimer s disease ad deciphering molecular mechanisms spatial transcriptomics ssread spatial transcriptomics st Alzheimers disease single cell RNA seq

Mitochondria-derived vesicles:New players in the game of neurodegeneration: 《Neural Regeneration Research》2026年第2期679-680,共2页Laura Palumbo Domenico Nuzzo Antonella Girgenti Pasquale Picone; supported by project Emerging Infectious Diseases One Health Basic and Translational Research Actions addressing Unmet Needs on Emerging Infectious Diseases,INF-ACT,Spoke 1 and Spoke 5,Project number PE00000007,CUP B53C20040570005(to PP and DN).; Introduction:One of the main events that regulate a cell’s well-being is cell-to-cell communication.This intercellular mechanism of information transfer is often mediated by vesicular trafficking.Mitochondrial-derive...; 关键词：extracellular vesicles cell cell communication vesicular traffickingmitochondrial derived NEURODEGENERATION mitochondria derived vesicles vesicular trafficking extracellular vesicle ev first

Amyloid-βis NOT only the most promising target for Alzheimer’s disease: 《Neural Regeneration Research》2026年第2期681-682,共2页Beka Solomon Milana Voronov-Goldman; Amyloid-β(Aβ)and tau,the two hallmark proteins associated with Alzheimer’s disease(AD),exhibit distinct toxic effects but also interact synergistically within the disease pathology.The prevailing theory in AD patho...; 关键词：amyloid precursor protein app initially intracellular peptides amyloid cascade hypothesis amyloid cascade hypothesis highlights AMYLOID tau Alzheimers disease SECRETASE

Fibrotic scar formation after cerebral ischemic stroke:Targeting the Sonic hedgehog signaling pathway for scar reduction: 《Neural Regeneration Research》2026年第2期756-768,共13页un Wen Hao Tang Mingfen Tian Ling Wang Qinghuan Yang Yong Zhao Xuemei Li Yu Ren Jiani Wang Li Zhou Yongjun Tan Haiyun Wu Xinrui Cai Yilin Wang Hui Cao Jianfeng Xu Qin Yang; supported by the National Natural Science Foundation of China,Nos.82171456(to QY)and 81971229(to QY);the Natural Science Foundation of Chongqing,Nos.CSTC2021JCYJ-MSXMX0263(to QY)and CSTB2023NSCQ-MSX1015(to XL);Doctoral Innovation Project of The First Affiliated Hospital of Chongqing Medical University,Nos.CYYY-BSYJSCXXM-202318(to JW)and CYYY-BSYJSCXXM-202327(to HT).; Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment.However,little is known about how fibrosis is induced and regulated after...; 关键词：central nervous system FIBROBLASTS fibrosis ischemic stroke Mitofusin 2 middle cerebral artery occlusion/reperfusion P-Smad3 Sonic Hedgehog SMAD3 TOM20

Metabolic reprogramming of astrocytes:Emerging roles of lactate: 《Neural Regeneration Research》2026年第2期421-432,共12页Zeyu Liu Yijian Guo Ying Zhang Yulei Gao Bin Ning; supported by the National Natural Science Foundation of China,Nos.82071383,82371392(to BN);the Natural Science Foundation of Shandong Province of China(Key Project),No.ZR2020KH007(to BN);“Taishan Scholar Distinguished Expert Program”of Shandong Province,No.tstp20231257(to BN);Health Commission Science and Technology Plan Project of Jinan,No.2023-1-8(to YZ).; Lactate serves as a key energy metabolite in the central nervous system,facilitating essential brain functions,including energy supply,signaling,and epigenetic modulation.Moreover,it links epigenetic modifications wit...; 关键词：ASTROCYTE epigenetic modifications inflammation LACTATE lactylation METABOLIC PLASTICITY regeneration treatment

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