FIBROBLASTS

作品数：341被引量：888H指数：12
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相关领域：医药卫生更多>>
相关作者：胡大海王春波丁擘晓刘洋王许杰更多>>
相关机构：复旦大学青岛大学第四军医大学西京医院上海交通大学医学院附属瑞金医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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Fibrotic scar formation after cerebral ischemic stroke:Targeting the Sonic hedgehog signaling pathway for scar reduction
《Neural Regeneration Research》2026年第2期756-768,共13页un Wen Hao Tang Mingfen Tian Ling Wang Qinghuan Yang Yong Zhao Xuemei Li Yu Ren Jiani Wang Li Zhou Yongjun Tan Haiyun Wu Xinrui Cai Yilin Wang Hui Cao Jianfeng Xu Qin Yang 
supported by the National Natural Science Foundation of China,Nos.82171456(to QY)and 81971229(to QY);the Natural Science Foundation of Chongqing,Nos.CSTC2021JCYJ-MSXMX0263(to QY)and CSTB2023NSCQ-MSX1015(to XL);Doctoral Innovation Project of The First Affiliated Hospital of Chongqing Medical University,Nos.CYYY-BSYJSCXXM-202318(to JW)and CYYY-BSYJSCXXM-202327(to HT).
Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment.However,little is known about how fibrosis is induced and regulated after...
关键词：central nervous system FIBROBLASTS fibrosis ischemic stroke Mitofusin 2 middle cerebral artery occlusion/reperfusion P-Smad3 Sonic Hedgehog SMAD3 TOM20 
《Silver Bullet of Acidification》: Studying Anti-PD Neuroprotective Mechanisms of Transient pH-Decrease
《BIOCELL》2025年第3期451-464,共14页Kristina A.Kritskaya Evgeniya I.Fedotova Alexander D.Nadeev Alexey V.Berezhnov 
supported by the Ministry of Science and Higher Education of the Russian Federation in the Framework of State Assignment of PSCBR RAS 075-00609-24-01(No.1022080100047-5-1.6.4,Neuroprotective drugs of a new generation).
Objective:Activation of mitophagy is a promising option to overcome the mitochondrial malfunction that accompanies many diseases.Herein,we investigate the mechanisms underlying the ability of sodium lactate and pyruva...
关键词：Parkinson’s disease mitochondrial network MITOPHAGY FIBROBLASTS 
Molecular mechanism of pancreatic ductal adenocarcinoma:The heterogeneity of cancer-associated fibroblasts and key signaling pathways
《World Journal of Clinical Oncology》2025年第2期18-28,共11页Zhong-Yuan Hu Ding Ding Yu Song Ya-Feng Deng Cheng-Ming Zhang Tao Yu 
Supported by National Key Research and Development Program Project,No.2017YFC1700601;Shaanxi Provincial Key Research and Development Program Project,No.2018SF-350;Leading Talents in Scientific and Technological Innovation of the Shaanxi Province Special Support Plan,No.00518。
Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival rate.This study offers a d...
关键词：Pancreatic cancer FIBROBLASTS Signaling pathways Tumor microenvironment 
Co-host ncRNA MIR503HG/miR-503-5p antagonistically interfere with the crosstalk between fibroblasts and microvascular endothelial cells by affecting the production of LMW FGF2 in pterygium
《International Journal of Ophthalmology(English edition)》2025年第2期199-208,共10页Yue-Qi Yuan Xing-Yuan Yan Fang Zheng Ming Yan 
Supported by the National Natural Science Foundation of China(No.81770898).
AIM:To explore the effect of co-host non-coding RNA(ncRNA)MIR503HG/miR-503-5p on the angiogenesis of pterygium.METHODS:MIR503HG/miR-503-5p/fibroblast growth factor 2(FGF2)expression levels in pterygium tissues,control...
关键词：PTERYGIUM MIR503HG miR-503-5p fibroblast growth factor 2 angiogenesis 
Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit
《Protein & Cell》2024年第12期906-929,共24页Hao Wang Junbo Yang Yihong Cai Yang Zhao 
supported by the National Key Research and Development Program of China(2018YFA0800504);the National Natural Science Foundation of China(31922020);funding provided by Plastech Pharmaceutical Technology Co.,Ltd.
Direct conversion of cardiac fibroblasts(CFs)to cardiomyocytes(CMs)in vivo to regenerate heart tissue is an attractive approach.After myocardial infarction(MI),heart repair proceeds with an inflammation stage initiate...
关键词：cardiac reprogramming heart regeneration microenvironment Ifnar1/2 
Correction to: Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit
《Protein & Cell》2024年第12期938-938,共1页
This is a correction to:Hao Wang,Junbo Yang,Yihong Cai,Yang Zhao,Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFNmediated intercellular self-stimulating circuit,Protein&Cell,2024;pwae013,https...
关键词：programming stimulating vivo 
Pinian powder in promoting proliferation of keratinocytes and fibroblasts through modulation of Wnt4/β-catenin signaling pathway and accelerating wound healing in mice with chronic skin ulcer
《World Journal of Integrated Traditional and Western Medicine》2024年第4期125-141,共17页ZENG Li LIU Qianwei LUO Simin YANG Zixuan XIAO Xiang XIAO Min 
supported by the National Natural Science Foundation of China(No.82004380).
Objective:Long-term effects of chronic skin ulcers(CSU)include diminished physical and emotional well-being,an increased risk of cancer in more severe cases,and significant social costs due to inadequate treatment.Pin...
关键词：Chronic skin ulcers(CSU) Pinian powder(PNP) Wnt4/β-catenin signaling KERATINOCYTES FIBROBLASTS Wound healing 
Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability
《Acta Biochimica et Biophysica Sinica》2024年第12期1802-1812,共11页Cong Wang Xiangchong Wang Yiyi Zhang Yuan Mi Yanxue Han Yaxin Zhi Ran Zhao Nanqi Cui Qianli Ma Huaxing Zhang Dazhong Xue Ruoyang Qiao Jiabing Han Yulou Yu Jiaxuan Li Mohammed Shaiea Demin Liu Guoqiang Gu Chuan Wang 
supported by the grants from the National Natural Science Foundation of China(Nos.81770407 and 31171097);the Key Project of Precision Medicine Joint Fund of Natural Science Foundation of Hebei Province(No.H2020206409);the College Students Innovative Pilot Project in Hebei Medical University(No.USIP2023011);the Science Fund for Creative Research Groups of Natural Science Foundation of Hebei Province(No.H2020206474).
Fibroblast growth factor(FGF)isoform 13,a distinct type of FGF,boasts significant potential for therapeutic intervention in cardiovascular dysfunctions.However,its impact on regulating fibrosis remains unexplored.This...
关键词：FGF13 cardiac fibrosis FIBROBLASTS MICROTUBULE ROCK 
Exploring Combined Immune Mechanisms of Acupuncture and Stretching—A Narrative Review
《Health》2024年第12期1268-1288,共21页Yiping Zhou Thelander Huijun Z. Ring Guikang Wei Yingqiu Wang Yinghua He Sheyian Bai Haisheng Zhang 
This narrative review explores the synergistic anti-inflammatory mechanisms of acupuncture and stretching. Acupuncture induces mechanical forces that activate neuro-immune pathways, modulating immune cell functions an...
关键词：ACUPUNCTURE Anti-Inflammatory Mechanisms FIBROBLASTS MACROPHAGES Mast Cells STRETCHING 
Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction
《Cancer Communications》2024年第11期1261-1286,共26页Yongcan Liu Shanchun Chen Xueying Wan Rui Wang Haojun Luo Chao Chang Peijin Dai Yubi Gan Yuetong Guo Yixuan Hou Yan Sun Yong Teng Xiaojiang Cui Manran Liu 
supported by National Key Projects of Ministry of Science and Technology of China(MOST 2018YFE0113700);National Natural Science Foundation of China(NSFC82173155,NSFC81874199);the Outstanding Professorship Program of Chongqing Medical University(2019-R10005)to Manran Liu;supported by the Outstanding Postgraduate Fund of Chongqing Medical University(BJRC202021,BJRC202025);the Chongqing Graduate Research and Innovation Project of the Chongqing Education Committee(CYB22218)for Shanchun Chen.
Background:Tumor metastasis is a major threat to cancer patient survival.The organ-specific niche plays a pivotal role in tumor organotropic metas-tasis.Fibroblasts serve as a vital component of the metastatic microen...
关键词：Matrix fibroblasts Lung metastasis Tryptophan 2 3-dioxygenase T cell dysfunction Ferropto-sis 
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