KERATINOCYTES

作品数：83被引量：182H指数：7
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相关领域：医药卫生生物学更多>>
相关作者：王文明陈福祥赵锐王燕妮唐国瑶更多>>
相关机构：北京协和医院南方医科大学第四军医大学上海交通大学医学院附属第九人民医院更多>>
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IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses
《Protein & Cell》2025年第3期188-210,共23页Xinmin Qian Meiyi Tong Tianqing Zhang Qingqing Li Meng Hua Nan Zhou Wenwen Zeng 
supported by the National Key R&D Program of China(2023YFC2306300);the National Natural Science Foundation of China(Grant Nos.32225019,92357304,and 32394003);supported by the Center for Life Sciences,the Institute for Immunology,and School of Basic Medical Sciences at Tsinghua University.
Atopic dermatitis(AD)is a prevalent inflammatory skin disorder in which patients experience recurrent eczematous lesions and intense itching.The colonization of Staphylococcus aureus(S.aureus)is correlated with the se...
关键词：IL-24 atopic dermatitis MRSA KERATINOCYTES allergic inflammation 
Aggregation-Induced Emission-Active Photosensitizer-Mediated Photodynamic Therapy for Anti-Psoriasis
《Research》2025年第1期935-954,共20页Ping Zhu Zhaoji Wu Zhilu Yang Tingting Tang Yunhui Liao Wen Zhao Ying Huang Tao Chen Junjie Li Chunmei Nong Zhenzhen Wu Guodong Hu Yanshan Liu Yinghua Chen 
supported by the Natural Science Funding of Guangdong Province(2022A1515012312 and 2021A1515010023);the National Natural Science Funding of China(82070083);Dongguan Social development technology projects Science and Technology Planning Project(20231800940792).
Hyperproliferative keratinocytes and subcutaneous inflammation contribute to the characteristic symptoms of psoriasis,including erythema,scales,or scaly plaques on the skin.These symptoms significantly affect patients...
关键词：PSORIASIS PHOTOSENSITIZER hyperproliferative keratinocytes subcutaneous inflammation scaly plaques organic photosensitizer photodynamic therapy treatment strategies 
Pinian powder in promoting proliferation of keratinocytes and fibroblasts through modulation of Wnt4/β-catenin signaling pathway and accelerating wound healing in mice with chronic skin ulcer
《World Journal of Integrated Traditional and Western Medicine》2024年第4期125-141,共17页ZENG Li LIU Qianwei LUO Simin YANG Zixuan XIAO Xiang XIAO Min 
supported by the National Natural Science Foundation of China(No.82004380).
Objective:Long-term effects of chronic skin ulcers(CSU)include diminished physical and emotional well-being,an increased risk of cancer in more severe cases,and significant social costs due to inadequate treatment.Pin...
关键词：Chronic skin ulcers(CSU) Pinian powder(PNP) Wnt4/β-catenin signaling KERATINOCYTES FIBROBLASTS Wound healing 
Restoring sweat gland function in mice using regenerative sweat gland cells derived from chemically reprogrammed human epidermal keratinocytes被引量：1
《Science Bulletin》2024年第24期3908-3924,共17页Jiangbing Xiang Huating Chen Hongliang Zhang Lu Wu Yan Li Shuaifei Ji Wei Pi Shaoyuan Cui Lei Dong Xiaobing Fu Xiaoyan Sun 
supported by the National Nature Science Foundation of China(92268206);the CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-059);the Military Medical Research Projects(2023-JSKY-SSQG-006);the Independent Research Project of State Key Laboratory of Trauma and Chemical Poisoning,the National Key Research and Development Program of China(2023YFC3011900);the Specific Research Fund of The Innovation Platform for Academicians of Hainan Province(YSPTZX202317);the Open Project of the State Key Laboratory of Trauma,Burn and Combined Injury,Third Military Medical University(SKLKF202301).
The regeneration of sweat glands(SwGs)plays a pivotal role in the functional recovery of extensive skin wounds.Recent research has illuminated the possibility of reprogramming human epidermal ker-atinocytes(HEKs)into ...
关键词：Human epidermal keratinocytes Sweat gland REGENERATION Chemical reprogramming 
Leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients With Metabolic Syndrome
《International Journal of Dermatology and Venereology》2024年第3期121-130,共10页Cui-Hao Song Rui Wang Zhen-Kai Zhao Yuan Zhang Jie Sun Xu Zhang Xiang-Yu Ding Jia Bai Xiao-Qiang Liang Xuan-Jin Wei Xiao-Ling Liu Tao Yang Xin-Lin Liang Cheng-Xin Li Bi-Wen Lin 
supported by Beijing Natural Science Foundation(No.7212097).
Objective:Psoriasis is associated with a high prevalence of metabolic syndrome(MS),and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment.However,the molecular mecha...
关键词：PSORIASIS metabolic syndrome LEPTIN AUTOPHAGY keratinocyte differentiation signal pathway PI3K/AKT/mTOR 
Skin care efficacy study of recombinant humanized collagen based on in vitro level
《日用化学工业（中英文）》2024年第9期1030-1038,共9页Jian Wang Yuhui Fan Danfeng Li Ningwen Cheng Ling Li Yufeng Yu 
Studying the skin care efficacy of recombinant humanized collagen based on in vitro level.The stability of the recombinant humanized collagen was first analyzed by treating at different temperatures,then its skincare ...
关键词：recombinant humanized collagen stability human fibroblast cell in vitro keratinocytes skin care efficacy 
The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection被引量：2
《Cellular & Molecular Immunology》2024年第6期533-545,共13页Yu Chen Yan Song Zhe Wang Yangfan Lai Wei Yin Qian Cai Miaomiao Han Yiheng Cai Yushan Xue Zhengrong Chen Xi Li Jing Chen Min Li Huabin Li Rui He 
Shanghai Science and Technology Commission 23ZR1461500(to RH);Key Laboratory of Medical Molecular Virology(MOE/NHC)FDMVK-2021001(to RH);The National Natural Science Foundation of China Grant 82271138(to HL);National Key Research and Development Program of China 2020YFC2005003(to JC).
The skin is the most common site of Staphylococcus aureus infection,which can lead to various diseases,including invasive and life-threatening infections,through evasion of host defense.However,little is known about t...
关键词：Chemerin-CMKLR1 Staphylococcus aureus NEUTROPHIL IL-33 KERATINOCYTES 
CD147 Facilitates the Pathogenesis of Psoriasis through Glycolysis and H3K9me3 Modification in Keratinocytes
《Research》2024年第1期509-523,共15页Chao Chen Xiaoqing Yi Panpan Liu Jie Li Bei Yan Detian Zhang Lei Zhu Pian Yu Lei Li Jiaxiong Zhang Yehong Kuang Shuang Zhao Wu Zhu Cong Peng Xiang Chen 
National Natural Science Grant Nos.82073458,82221002,82130090,81830096,81974476,and 82173424;the Science and Technology Innovation Program of Hunan Province(2021RC4013);the Program of Introducing Talents of Discipline to Universities(111 Project,No.B20017).
Psoriasis is a chronic inflammatory skin disease featuring rapid proliferation of epidermal cells.Although elevated glycolysis flux has been reported in psoriasis,the molecular mechanisms underlying its pathogenesis r...
关键词：CD147 PATHOGENESIS markedly 
Optimization of LPS-Induced Inflammation Model and Its Feasibility as a Fast Screening Model for Cosmetics
《Journal of Cosmetics, Dermatological Sciences and Applications》2024年第1期84-97,共14页Fanghui Sun Xiaojie Song Nannan Liu Gang Huo 
Objectives: The existing inflammatory models are concentrated in relatively complex medical fields, and most of them use a single type of cell, and the induction conditions are not uniform, so the current LPS-induced ...
关键词：Cell Culture ANTI-INFLAMMATORY LIPOPOLYSACCHARIDE KERATINOCYTES THP-1 Inflammatory Factors 
Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes被引量：1
《Chinese Journal of Integrative Medicine》2024年第3期222-229,共8页ZHANG Shuo LI Hong-jin YANG Chun-mei LIU Liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU Yi HU Man-qi YAN Ge ZHOU Ya-qiong MIAO Xiao LI Xin LI Bin 
Supported by the National Natural Science Foundation of China (Nos.81973860, 82074427);Shanghai Pujiang Talent Program (No.2020PJD067);Science and Technology Commission of Shanghai Municipality (Nos.21Y21920100, 21Y21920102)。
Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological perspective.Methods:Mouse models of psoriatic dermatitis were establ...
关键词：PSORIASIS Tripterygium wilfordii multiglycoside γδT cells INFLAMMATION Chinese medicine 
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