INFLAMMATION

作品数：2584被引量：12917H指数：42
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相关机构：复旦大学首都医科大学武汉大学浙江大学更多>>
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Chitosan alleviates symptoms of Parkinson's disease by reducing acetate levels, which decreases inflammation and promotes repair of the intestinal barrier and blood–brain barrier
《Neural Regeneration Research》2026年第1期377-391,共15页Yinying Wang Rongsha Chen Guolin Shi Xinwei Huang Ke Li Ruohua Wang Xia Cao Zhongshan Yang Ninghui Zhao Jinyuan Yan 
supported by the National Natural Science Foundation of China,Nos. 32260196 (to JY), 81860646 (to ZY) and 31860274 (to JY);a grant from Yunnan Department of Science and Technology,Nos. 202101AT070251 (to JY), 202201AS070084 (to ZY), 202301AY070001-239 (to JY), 202101AZ070001-012, and 2019FI016 (to ZY)。
Studies have shown that chitosan protects against neurodegenerative diseases. However, the precise mechanism remains poorly understood. In this study, we administered chitosan intragastrically to an MPTP-induced mouse...
关键词：ACETATE adenosine 5′-monophosphate-activated protein kinase blood–brain barrier CHITOSAN dopamine neurons INFLAMMATION intestinal barrier Parkinson's disease peroxisome proliferator-activated receptor delta short-chain fatty acids 
Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets
《Neural Regeneration Research》2025年第10期2787-2806,共20页Qingcong Zheng Du Wang Rongjie Lin Weihong Xu 
supported by the Natural Science Foundation of Fujian Province,No.2021J02035(to WX).
Regulated cell death is a form of cell death that is actively controlled by biomolecules.Several studies have shown that regulated cell death plays a key role after spinal cord injury.Pyroptosis and ferroptosis are ne...
关键词：AUTOPHAGY cell death ferroptosis INFLAMMATION pathological mechanisms PYROPTOSIS regulated cell death regulatory pathways spinal cord injury therapeutic targets 
Total adenosine deaminase cases as an inflammatory biomarker of pleural effusion syndrome
《World Journal of Clinical Cases》2025年第19期14-23,共10页Bernardo Henrique Ferraz Maranhão Cyro Teixeira da Silva Junior Jorge Luiz Barillo Joeber Bernardo Soares Souza Patricia Siqueira Silva Roberto Stirbulov 
BACKGROUND Although inflammatory diseases commonly affect the pleura and pleural space,their mechanisms of action remain unclear.The presence of several mediators emphasizes the concept of pleural inflammation.Adenosi...
关键词：Pleural effusion BIOMARKER Adenosine deaminase INFLAMMATION transudate EXUDATE 
Neuroinflammation revisited through the microglial lens
《Neural Regeneration Research》2025年第7期1989-1990,共2页Renato Socodato João B.Relvas 
funded by Portuguese funds through FCT——Funda??o para a Ciência e a Tecnologia/Ministério da Ciência,Tecnologia e Ensino Superior in the framework of the project PTDC/MEDNEU/1677/2021(to JBR)。
Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune system.This exploration is particularly significant in understanding micro...
关键词：INFLAMMATION simplified ACTIVATION 
PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation
《Neural Regeneration Research》2025年第7期1993-1994,共2页Anup Bhusal Won-Ha Lee Kyoungho Suk 
supported by a grant from the Basic Science Research Program through the National Research Foundation(NRF),which is funded by the Korean government(MSIP)(NRF-2020M3E5D9079764)(to KS)。
Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.
关键词：INFLAMMATION considerably 
Therapeutic potential of integrins in diabetic retinopathy
《World Journal of Diabetes》2025年第5期109-118,共10页Li-Mei He Sarul Borjigin Xin-Qi Chen Zhao-Li Yan Ming-Jie Wang 
Supported by the Natural Science Foundation of Inner Mongolia,No.2022MS08057;2022 Autonomous Region Medical and Health Science and Technology Plan Projects,No.202202190.
Diabetic retinopathy(DR),a leading cause of visual loss,is the result of microvascular damage induced by prolonged hyperglycemia.Numerous studies have revealed the pivotal role of integrins in the pathogenesis of DR,p...
关键词：Diabetic retinopathy INTEGRIN INFLAMMATION Microvascular permeability Microthrombus formation ANGIOGENESIS Integrin inhibitor 
Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in diabetic neuropathic pain via aldose reductase
《World Journal of Diabetes》2025年第5期346-362,共17页Xue-Zhen Zheng Hong-Yan Yu Ye-Ru Chen Jian-Sheng Fang 
Supported by National Natural Science Foundation of China,No.82001424.
BACKGROUND Treatment of diabetic neuropathy is often limited by side effects.Aucubin,an iridoid glycoside derived from natural plants,exhibits notable anti-inflammatory and antioxidant properties.AIM To investigate th...
关键词：Diabetic neuropathic pain AUCUBIN GLYCOLYSIS Aldose reductase MICROGLIA 
T cell interactions with microglia in immune-inflammatory processes of ischemic stroke
《Neural Regeneration Research》2025年第5期1277-1292,共16页Yuxiao Zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang 
supported by the National Natural Science Foundation of China,Nos.82104560(to CL),U21A20400(to QW);the Natural Science Foundation of Beijing,No.7232279(to XW);the Project of Beijing University of Chinese Medicine,No.2022-JYB-JBZR-004(to XW)。
The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue regeneration.As the first i...
关键词：BRAIN IMMUNE INFLAMMATION interaction ischemic stroke mechanism MICROGLIA NEURON secondary injury T cells 
MicroRNA-122-5p is upregulated in diabetic foot ulcers and decelerates the transition from the inflammatory to the proliferative stage
《World Journal of Diabetes》2025年第4期236-251,共16页Mei-Jie Yuan He-Chen Huang Hong-Shuo Shi Xiao-Ming Hu Zhuo Zhao Yu-Qi Chen Wei-Jing Fan Jian Sun Guo-Bin Liu 
Supported by the National Natural Science Foundation of China,No.82274528.
BACKGROUND Shifting from the inflammatory to the proliferative phase represents a pivotal step during managing diabetic foot ulcers(DFUs);however,existing medical interventions remain insufficient.MicroRNAs(miRs)highl...
关键词：MicroRNA-122-5p Diabetic foot ulcer Wound healing INFLAMMATION FIBROSIS 
Advances in Research of Traditional Chinese Medicine in the Treatment of Prostatitis through p38MAPK Signaling Pathway
《Medicinal Plant》2025年第2期71-74,共4页Biaoqing LI 
Supported by Natural Science Foundation of Hainan Province(820RC788).
Prostatitis is a common genitourinary disease characterized by a complex pathogenesis involving infection,inflammation,oxidative stress,and immune dysfunction.The p38MAPK signaling pathway plays a key role in inflamma...
关键词：PROSTATITIS Traditional Chinese medicine P38MAPK INFLAMMATION Mechanism 
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