Therapeutic potential of integrins in diabetic retinopathy  

作　　者：Li-Mei He Sarul Borjigin Xin-Qi Chen Zhao-Li Yan Ming-Jie Wang 

机构地区：[1]Department of Internal Medicine,Inner Mongolia Medical University,Hohhot 010000,Inner Mongolia Autonomous Region,China [2]Department of Endocrinology,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,Inner Mongolia Autonomous Region,China

出　　处：《World Journal of Diabetes》2025年第5期109-118,共10页世界糖尿病杂志(英文)

基　　金：Supported by the Natural Science Foundation of Inner Mongolia,No.2022MS08057;2022 Autonomous Region Medical and Health Science and Technology Plan Projects,No.202202190.

摘　　要：Diabetic retinopathy(DR),a leading cause of visual loss,is the result of microvascular damage induced by prolonged hyperglycemia.Numerous studies have revealed the pivotal role of integrins in the pathogenesis of DR,particularly in key processes such as inflammation,vascular leakage,microthrombus formation,and angiogenesis.Consequently,targeting integrins is considered a promising strategy for the treatment of DR.This review focuses on the function of integrins in DR and their potential as therapeutic targets.It describes the molecular mechanisms through which integrins influence DR progression and summarizes the latest outcomes of integrin antagonist-based therapeutic strategies in clinical studies,evaluating their efficacy and potential challenges,which offer promise as novel treatment options for DR.

关 键 词：Diabetic retinopathy INTEGRIN INFLAMMATION Microvascular permeability Microthrombus formation ANGIOGENESIS Integrin inhibitor 

分 类 号：R774.1[医药卫生—眼科]