GLYCOLYSIS

作品数：258被引量：812H指数：11
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相关作者：金阳刘秀梅胡振宇张芬芬杨振军更多>>
相关机构：复旦大学中山大学附属第八医院(深圳福田)华中科技大学华南农业大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy
《Neural Regeneration Research》2025年第8期2264-2278,共15页You Wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao 
supported by the National Natural Science Foundation of China,No.82271214(to ZY);the Natural Science Foundation of Hubei Province of China,No.2022CFB109(to ZY)。
Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative treatments.The current therapeutic strategies,primarily based on cholinest...
关键词：Alzheimer’s disease glial cells GLYCOLYSIS neuronal metabolism PATHOGENESIS therapeutic targets 
Role of PFKM lactylation in glycolysis regulation in endometrial cancer cells
《Genes & Diseases》2025年第3期27-30,共4页Bin Wang Jian Ma Di Yang 
supported by the National Natural Science Foundation of China(No.82203469);the Liaoning Province Joint Fund General Project(China)(No.2023-MSLH-166).
The incidence of endometrial cancer(EC)is increasing,particularly in high-risk cases with poor prognosis.1 Reprogramming glucose metabolism is the main feature of energy metabolism in EC cells,resulting in substantial...
关键词：lactic acid PFKM lactylation endometrial cancer ec reprogramming glucose metabolism glycolysis regulation metabolic process tumor cells modifying key proteins 
Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in diabetic neuropathic pain via aldose reductase
《World Journal of Diabetes》2025年第5期346-362,共17页Xue-Zhen Zheng Hong-Yan Yu Ye-Ru Chen Jian-Sheng Fang 
Supported by National Natural Science Foundation of China,No.82001424.
BACKGROUND Treatment of diabetic neuropathy is often limited by side effects.Aucubin,an iridoid glycoside derived from natural plants,exhibits notable anti-inflammatory and antioxidant properties.AIM To investigate th...
关键词：Diabetic neuropathic pain AUCUBIN GLYCOLYSIS Aldose reductase MICROGLIA 
Andrographolide sulfonate alleviates rheumatoid arthritis by inhibiting glycolysis-mediated activation of PI3K/AKT to restrain Th17 cell differentiation
《Chinese Journal of Natural Medicines》2025年第4期480-491,共12页Chunhong Jiang Xi Zeng Jia Wang Xiaoqian Wu Lijuan Song Ling Yang Ze Li Ning Xie Xiaomei Yuan Zhifeng Wei Yi Guan 
supported by the project of Central Funds Guiding the Local Science and Technology Development(No.20212ZDD02010)。
Andrographolide sulfonate(AS)is a sulfonated derivative of andrographolide extracted from Andrographis paniculata(Burm.f.)Nees,and has been approved for several decades in China.The present study aimed to investigate ...
关键词：Andrographolide sulfonate Rheumatoid arthritis Th17 cell differentiation GLYCOLYSIS PI3K/AKT pathway 
Metabolic reprogramming: a new option for the treatment of spinal cord injury
《Neural Regeneration Research》2025年第4期1042-1057,共16页Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang 
supported by the National Natural Science Foundation of China,No.82202681(to JW);the Natural Science Foundation of Zhejiang Province,Nos.LZ22H090003(to QC),LR23H060001(to CL).
Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they cause.Despite the ongoing development of various therapies for spinal cord injuries,their effectiveness ...
关键词：AXONS GLYCOLYSIS metabolic reprogramming metabolism mitochondria neural regeneration NEUROPROTECTION oxidative phosphorylation spinal cord injury therapy 
Impact of SLC16A8 on tumor microenvironment and angiogenesis in colorectal cancer: New therapeutic target insights
《World Journal of Gastrointestinal Oncology》2025年第4期300-317,共18页Hong-Peng Tian Zhong-Xiang Xiao Bo-Wen Su Yi-Xuan Li Hong Peng Chang-Yuan Meng 
Supported by Nanchong Science and Technology Plan Project,No.23JCYJPT0064;Project of Sichuan Provincial Administration of Traditional Chinese Medicine,No.2024MS590。
BACKGROUND SLC16A8,a lactate efflux transporter,is upregulated in various cancers,but its effects on tumor microenvironments remain understudied.This research explores its role in colorectal cancer(CRC)and the impact ...
关键词：SLC16A8 Colorectal cancer HYPOXIA GLYCOLYSIS ANGIOGENESIS 
Emd-D inhibited ovarian cancer progression via PFKFB4-dependent glycolysis and apoptosis
《Chinese Journal of Natural Medicines》2025年第4期431-442,共12页Xin Zhao Chao Chen Xuefei Feng Haoqi Lei Lingling Qi Hongxia Zhang Haiying Xu Jufeng Wan Yan Zhang Baofeng Yang 
funded by the Natural Science Foundation of Heilongjiang Province(No.LH2023H012);Postdoctoral Research Initiation Fund(No.LBH-Q20152);CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-078)。
Ovarian cancer poses a significant threat to women's health,necessitating effective therapeutic strategies.Emd-D,an emodin derivative,demonstrates enhanced pharmaceutical properties and bioavailability.In this study,C...
关键词：Ovarian cancer Emd-D GLYCOLYSIS APOPTOSIS PFKFB4 
NAD+/SIRT1 pathway regulates glycolysis to promote oxaliplatin resistance in colorectal cancer
《World Journal of Gastroenterology》2025年第11期118-134,共17页Ya-Ru Niu Mi-Dan Xiang Wen-Wei Yang Yu-Ting Fang Hai-Li Qian Yong-Kun Sun 
Supported by the National Natural Science Foundation of China,No.82072756;Beijing Xisike Clinical Oncology Research Foundation,No.Y-HR2019-0285.
BACKGROUND Glycolysis provides growth advantages and leads to drug resistance in colorectal cancer(CRC)cells.SIRT1,an NAD+-dependent deacetylase,regulates various cellular processes,and its upregulation results in ant...
关键词：Colorectal cancer Chemotherapy resistance GLYCOLYSIS SIRT1 NAD+ 
Apatinib regulates the glycolysis of vascular endothelial cells through PI3K/AKT/PFKFB3 pathway in hepatocellular carcinoma
《World Journal of Gastroenterology》2025年第11期135-152,共18页Yi Wu Bin-Bin Xie Bing-Liang Zhang Qing-Xin Zhuang Shi-Wei Liu Hong-Ming Pan 
Supported by the National Natural Science Foundation of China,No.82100542 and No.81802842.
BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent and aggressive malignancy in the Chinese population;the severe vascularization by the tumor makes it difficult to cure.The high incidence and poor survival rates ...
关键词：Apatinib Hepatocellular carcinoma Vascular endothelial cells GLYCOLYSIS Phosphatidylinositol 3-kinase Protein kinase B 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase 3 
Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production
《Neural Regeneration Research》2025年第3期671-681,共11页Angelid Pabon Jagannatham Naidu Bhupana Ching-On Wong 
supported by the NIH grant R01AG081379 (to CW)。
Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy...
关键词：AUTOPHAGY BIOENERGETICS endolysosome energy production GLYCOLYSIS metabolic reprogramming MITOCHONDRIA 
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