Metabolic reprogramming: a new option for the treatment of spinal cord injury  

作　　者：Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang 

机构地区：[1]Department of Orthopedics,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China [2]Orthopedics Research Institute of Zhejiang University,Zhejiang University,Hangzhou,Zhejiang Province,China [3]Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province,Hangzhou,Zhejiang Province,China [4]Clinical Research Center of Motor System Disease of Zhejiang Province,Hangzhou,Zhejiang Province,China [5]Qiandongnan Prefecture People’s Hospital,Kaili,Guizhou Province,China [6]Department of Orthopedics,Fourth Medical Center,Chinese PLA General Hospital,Beijing,China

出　　处：《Neural Regeneration Research》2025年第4期1042-1057,共16页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.82202681(to JW);the Natural Science Foundation of Zhejiang Province,Nos.LZ22H090003(to QC),LR23H060001(to CL).

摘　　要：Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they cause.Despite the ongoing development of various therapies for spinal cord injuries,their effectiveness remains unsatisfactory.However,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic reprogramming.In this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic reprogramming.Normal spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic coupling.However,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial dysfunction.These metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of microglia.To rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell fate.The available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord injury.To further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关 键 词：AXONS GLYCOLYSIS metabolic reprogramming metabolism mitochondria neural regeneration NEUROPROTECTION oxidative phosphorylation spinal cord injury therapy 

分 类 号：R651.2[医药卫生—外科学]