NEUROPROTECTION

作品数：693被引量：3170H指数：23
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相关机构：河北医科大学第二医院第四军医大学西京医院哈尔滨医科大学武警总医院更多>>
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Microglial intervention in ischemic stroke:Roles and intervention strategies
《Neural Regeneration Research》2026年第2期443-454,共12页Cuiling Ji Lixinbei Sheng Kaijun Han Ping Yuan Wei Li Lu Chen Yongyue Gao 
supported by the National Natural Science Foundation of China,82471345(to LC);the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...
关键词：blood-brain barrier ischemic stroke MICROGLIA nerve regeneration NEUROINFLAMMATION NEUROPROTECTION oxidative stress polarization signaling pathways therapeutic strategies 
Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes
《Neural Regeneration Research》2026年第2期800-810,共11页Yu-Qi Shao Yong-Chen Wang Lu Wang Hang-Ze Ruan Yun-Feng Liu Ti-Hui Zhang Shi-Jun Weng Xiong-Li Yang Yong-Mei Zhong 
supported by the National Natural Science Foundation of China,Nos.32070989(to YMZ),31872766(to YMZ),81790640(to XLY),and 82070993(to SJW);the grant from Sanming Project of Medicine in Shenzhen,No.SZSM202011015(to XLY)。
Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission ...
关键词：diabetic retinopathy glucagon-like peptide-1 inhibitory synaptic transmission miniature inhibitory postsynaptic currents NEURODEGENERATION NEUROPROTECTION patch-clamp recording protein kinase C signaling pathway visual function 
Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress
《Neural Regeneration Research》2026年第1期333-345,共13页Yumei Liao Qinghua Zhang Qiaoyun Shi Peng Liu Peiyun Zhong Lingling Guo Zijian Huang Yinghui Peng Wei Liu Shiqing Zhang István Adorján Yumi Fukuzaki Eri Kawashita Xiao-Qi Zhang Nan Ma Xiaoshen Zhang Zoltán Molnár Lei Shi 
supported in part by the National Key Research&Development Program of China,No. 2022YFA1104900 (to LS);the National Natural Science Foundation of China,Nos. 82371175, 82071535 (both to LS), 82101614 (to YP);the International Science and Technology Cooperation Projects of Guangdong Province,No. 2023A0505050121 (to LS);Guangdong Basic and Applied Basic Research Foundation,Nos. 2022B1515130007 (to LS), 2023A1515030012 (to SZ), 2022A1515010666 (to WL);the Science and Technology Program of Guangzhou,Nos. 202102070001 (to LS), 202201010041 (to YP);Shenzhen Basic Research Grant,Nos. JCYJ20200109140414636, JCYJ20230807145103007 (both to WL);awarded a Royal Society Newton Advanced Fellowship,No. AOMS-NAF0051003;in collaboration with Zoltán Molnár,Department of Physiology,Anatomy and Genetics,University of Oxford (2017–2021)。
Neuroserpin, a secreted protein that belongs to the serpin superfamily of serine protease inhibitors, is highly expressed in the central nervous system and plays multiple roles in brain development and pathology. As a...
关键词：endoplasmic reticulum stress ischemia-reperfusion injury NEURON neuronal apoptosis NEUROPROTECTION NEUROSERPIN protein synthesis secretory protein stroke transcriptomic analysis 
Aerobic exercise–induced myokine irisin release:A novel strategy to promote neuroprotection and improve cognitive function
《Neural Regeneration Research》2026年第1期306-307,共2页Jae-Won Choi Rengasamy Balakrishnan 
supported by The Basic Science Research Program through the National Research Foundation of Korea(NRF);funded by the Ministry of Education(RS-2023-00244901)(to RB)。
Challenges in the prevention and treatment of mild cognitive impairment associated with Alzheimer's disease:Increased life expectancy due to advancements in medical care has given rise to an aging population,accompani...
关键词：PREVENTION DISEASES COGNITIVE 
Bidirectional causality of physical exercise in retinal neuroprotection
《Neural Regeneration Research》2025年第12期3400-3415,共16页Stephen K.Agadagba Suk-yu Yau Ying Liang Kristine Dalton Benjamin Thompson 
supported by the InnoHK Initiative and the Hong Kong Special Administrative Region Government, China (to SYY)。
Physical exercise is recognized as an effective intervention to improve mood,physical performance,and general well-being.It achieves these benefits through cellular and molecular mechanisms that promote the release of...
关键词：age-related macular degeneration biomarkers diabetic retinopathy GLAUCOMA neuroprotective factors ocular diseases physical exercise retinal neuroprotection retinitis pigmentosa visual impairment 
Corrigendum: Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke
《Neural Regeneration Research》2025年第12期3429-3429,共1页
Epigenetic regulation of the inflammatory response in stroke
《Neural Regeneration Research》2025年第11期3045-3062,共18页Jingyi Liang Fei Yang Zixiao Li Qian Li 
supported by the National Natural Science Foundation of China,Nos.32070735(to QL),82371321(to QL),82171270(to ZL);Public Service Platform for Artificial Intelligence Screening and Auxiliary Diagnosis for the Medical and Health Industry,Ministry of Industry and Information Technology of the People's Republic of China,No.2020-0103-3-1(to ZL);the Natural Science Foundation of Beijing,No.Z200016(to ZL);Beijing Talents Project,No.2018000021223ZK03(to ZL);Beijing Municipal Committee of Science and Technology,No.Z201100005620010(to ZL)。
Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either type.Immunologic mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytoki...
关键词：DNA methylation histone modification intracerebral hemorrhage ischemic stroke NEUROINFLAMMATION NEUROPROTECTION non-coding RNA RNA methylation subarachnoid hemorrhage treatment 
Corrigendum:Neuroprotection mediated by the Wnt/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage
《Neural Regeneration Research》2025年第11期3123-3123,共1页
In the article titled“Neuroprotection mediated by the Wnt/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage,”published on pages 1013-1024,Issue 6,Volume 14 of Neural Regeneration Re...
关键词：HEMORRHAGE COR 
PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives
《Neural Regeneration Research》2025年第10期2758-2775,共18页Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen Minna Liu Yi Ding 
supported by the National Natural Science Foundation of China,Nos.82274313(to YD),82204746(to ML),82003982(to TL).
It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic stroke.As a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing a...
关键词：apoptosis autophagy inflammation ischemic stroke NEUROPROTECTION oxidative stress PATHOGENESIS phosphatidylinositol 3-kinase protein kinase B THERAPEUTICS 
Neuroprotective potential for mitigating ischemia-reperfusion-induced damage
《Neural Regeneration Research》2025年第8期2199-2217,共19页Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng Hua Yang 
Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion injury.Current s...
关键词：apoptosis autophagy blood-brain barrier dietary supplements drug HORMONES inflammation NEUROPROTECTION oxidative stress prognosis PYROPTOSIS reperfusion injury risk factors RNA THERAPEUTICS 
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