PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives  

作　　者：Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen Minna Liu Yi Ding 

机构地区：[1]Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi’an,Shaanxi Province,China [2]Department of Pharmacy,The 940 Hospital of Joint Logistics Support Forces of Chinese PLA,Lanzhou,Gansu Province,China [3]Department of Pharmacy,The 944 Hospital of Joint Logistics Support Forces of Chinese PLA,Jiuquan,Gansu Province,China [4]Department of Nephrology,The 940 Hospital of Joint Logistics Support Forces of Chinese PLA,Lanzhou,Gansu Province,China

出　　处：《Neural Regeneration Research》2025年第10期2758-2775,共18页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82274313(to YD),82204746(to ML),82003982(to TL).

摘　　要：It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic stroke.As a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from researchers.This article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling pathway.The key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic stroke.Future investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关 键 词：apoptosis autophagy inflammation ischemic stroke NEUROPROTECTION oxidative stress PATHOGENESIS phosphatidylinositol 3-kinase protein kinase B THERAPEUTICS 

分 类 号：R743.3[医药卫生—神经病学与精神病学]