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PATHOGENESIS: 作品数：1199被引量：6691H指数：39; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：袁红张韶峰刘平白丽敏郑静晨更多>>; 相关机构：北京中医药大学哈尔滨医科大学武警总医院温州医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>

Potential mechanisms of non-coding RNA regulation in Alzheimer's disease: 《Neural Regeneration Research》2026年第1期265-280,共16页Yue Sun Xinping Pang Xudong Huang Dinglu Liu Jingyue Huang Pengtao Zheng Yanyu Wei Chaoyang Pang; Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological ch...; 关键词：Alzheimer's disease biomarkers circular RNA long non-coding RNA microRNA ncRNA regulation NEURODEGENERATION non-coding RNA PATHOGENESIS therapeutic targets

Age-dependent alpha-synuclein aggregation and Lewy body formation in Parkinson's disease: 《Neural Regeneration Research》2025年第12期3533-3534,共2页Chun Chau Sung Kenny K.K.Chung; supported by the Innovation and Technology Commission (ITCPD/17-9);the Hong Kong Research Grants Council,China (GRF16104517)(to KKKC)。; Parkinson's disease (PD) is a common degenerative disorder that is becoming increasingly prevalent because of the global aging population.The exact cause of the disorder is unknown;however,recent studies have suggeste...; 关键词：PATHOGENESIS AGGREGATION BECOMING

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives: 《Neural Regeneration Research》2025年第10期2758-2775,共18页Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen Minna Liu Yi Ding; supported by the National Natural Science Foundation of China,Nos.82274313(to YD),82204746(to ML),82003982(to TL).; It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic stroke.As a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing a...; 关键词：apoptosis autophagy inflammation ischemic stroke NEUROPROTECTION oxidative stress PATHOGENESIS phosphatidylinositol 3-kinase protein kinase B THERAPEUTICS

Research progress on cognitive impairment in patients with obstructive sleep apnea-hypopnea syndrome: 《Nursing Communications》2025年第9期1-8,共8页Jin-Rui Fei Chun-Guang Liang Yu-Ge Wang Yue Zhu; supported by the 2023 Jinzhou Medical University Education and Teaching Research and Reform Project(YB2023004).; Obstructive sleep apnea-hypopnea syndrome(OSAHS)is a common form of sleep breathing disorder characterized by apnea and hypopnea resulting from recurrent upper airway obstruction during sleep.This leads to intermitten...; 关键词：obstructive sleep apnea-hypopnea syndrome cognitive impairment PATHOGENESIS assessment tool influencing factor REVIEW

Gut virome and its emerging role in inflammatory bowel disease: 《World Journal of Methodology》2025年第3期22-24,共3页Rahat Khatoon Khokhar Abdulqadir J Nashwan; Inflammatory bowel disease(IBD)is a progressive multifactorial inflammatory disease of the gut.The cause of IBD is yet unknown.Some researchers have shown that genetic factors,environmental factors,and the gut microbi...; 关键词：Inflammatory bowel disease PATHOGENESIS Gut virome BACTERIOPHAGE Eukaryotic viruses

Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy: 《Neural Regeneration Research》2025年第8期2264-2278,共15页You Wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao; supported by the National Natural Science Foundation of China,No.82271214(to ZY);the Natural Science Foundation of Hubei Province of China,No.2022CFB109(to ZY)。; Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative treatments.The current therapeutic strategies,primarily based on cholinest...; 关键词：Alzheimer’s disease glial cells GLYCOLYSIS neuronal metabolism PATHOGENESIS therapeutic targets

Gut virome:New key players in the pathogenesis of inflammatory bowel disease被引量：1: 《World Journal of Methodology》2025年第2期27-43,共17页Helal F Hetta Rehab Ahmed Yasmin N Ramadan Hayam Fathy Mohammed Khorshid Mohamed M Mabrouk Mai Hashem; Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the intes-tine.While the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immu...; 关键词：Inflammatory bowel disease PATHOGENESIS Gut virome BACTERIOPHAGE Eukaryotic viruses

Matrix metalloproteinases and their tissue inhibitors as indicators of aortic aneurysm and dissection development in extracellular matrix remodeling: 《World Journal of Experimental Medicine》2025年第2期1-11,共11页Marc Irqsusi Fiona R Rodepeter Madeline Günther Andreas Kirschbaum Sebastian Vogt; Aneurysms and dissections represent some of the most serious cardiovascular diseases.The prevailing theory posits that mechanical overloading of the vessel wall is the underlying cause.Inspired by Barkhordarian et al,...; 关键词：Matrix metalloproteinases Tissue inhibitor of metalloproteinases Acute aortic dissection Aortic aneurysm Extracellular matrix remodeling PATHOGENESIS

The multifaceted role of post-translational modifications of LSD1 in cellular processes and disease pathogenesis: 《Genes & Diseases》2025年第3期168-179,共12页Yinrui Li Bo Wang Yichao Zheng Huiqin Kang Ang He Lijuan Zhao Ningjie Guo Hongmin Liu Adil Mardinoglu M.A.A.Mamun Ya Gao Xiaobing Chen; supported by the Basic Research of Medical Science and Technique Foundation of Henan Province,China(No.SBGJ202301004 to X.B.C.);the Key Project of the High Education from the Education Department of Henan Province,China(No.22ZX008 to Y.C.Z.);the Youth Supporting Program from Henan Province,China(No.2021HYTP060 to Y.C.Z.);the Youth Supporting Program from Zhengzhou University(No.JC202044046 to Y.C.Z.);the Science and Technology Project of Henan Province,China(No.232102311179 to Y.G.);the National Natural Science Foundation of China(No.U21A20416,82020108030 to H.M.L,82103997 to B.W.);the China Postdoctoral Science Foundation(No.2021M692950 to B.W.,2021M702942 to L.J.Z.).; Post-translational modifications(PTMs)of proteins play a crucial role in living organisms,altering the properties and functions of proteins.There are over 450 known PTMs involved in various life activities.LSD1(lysine...; 关键词：Enzyme activity Histone demethylase Human diseases LSD1 POST-TRANSLATIONAL

Relationship between Helicobacter pylori infection and programmed death-ligand 1 in gastric cancer:A meta-analysis: 《World Journal of Clinical Oncology》2025年第4期280-290,共11页Hong-Chang Yang Cheng-Feng Fu Li-Jun Qiao Gen-He Long Li-Fen Yang Biao Yao; BACKGROUND Gastric cancer(GC)is one of the most common malignancies worldwide,and Helicobacter pylori(HP)infection is a well-established risk factor for its development.Programmed death-ligand 1(PD-L1)expression is a ...; 关键词：Helicobacter pylori Gastric cancer Programmed cell death protein 1/programmed death-ligand 1 Immune checkpoint blockade therapy PATHOGENESIS

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