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THERAPEUTICS: 作品数：507被引量：1768H指数：18; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：陆世锋赫军王剑王琳蒋天安更多>>; 相关机构：沈阳大陆激光技术有限公司中国科学院上海生命科学研究院北京工业大学广西中医药大学第一附属医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划上海市自然科学基金更多>>

NLRP3 inflammasome and gut microbiota–brain axis:A new perspective on white matter injury after intracerebral hemorrhage: 《Neural Regeneration Research》2026年第1期62-80,共19页Xiaoxi Cai Xinhong Cai Quanhua Xie Xueqi Xiao Tong Li Tian Zhou Haitao Sun; supported by the Guangdong Basic and Applied Basic Research Foundation,No.2023A1515030045(to HS);Presidential Foundation of Zhujiang Hospital of Southern Medical University,No.yzjj2022ms4(to HS)。; Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have rev...; 关键词：gut microbiota gut microbiota–brain axis immune intracerebral hemorrhage NEUROINFLAMMATION NLRP3 protein stroke THERAPEUTICS white matter injury

Aptamers as new promising entities for therapeutics:our experience from the neurological diseases: 《Neural Regeneration Research》2025年第12期3523-3524,共2页Macarena Hernández-Jiménez Fernando de Castro; Based on data from Global Burden of Disease,Injuries,and Risk Factors(2024),disorders of the central nervous system(CNS)are an important cause of death or long-term disability,representing the top-ranked contributor t...; 关键词：DISEASES CONGENITAL IMPAIRMENT

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives: 《Neural Regeneration Research》2025年第10期2758-2775,共18页Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen Minna Liu Yi Ding; supported by the National Natural Science Foundation of China,Nos.82274313(to YD),82204746(to ML),82003982(to TL).; It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic stroke.As a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing a...; 关键词：apoptosis autophagy inflammation ischemic stroke NEUROPROTECTION oxidative stress PATHOGENESIS phosphatidylinositol 3-kinase protein kinase B THERAPEUTICS

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage: 《Neural Regeneration Research》2025年第8期2199-2217,共19页Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng Hua Yang; Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion injury.Current s...; 关键词：apoptosis autophagy blood-brain barrier dietary supplements drug HORMONES inflammation NEUROPROTECTION oxidative stress prognosis PYROPTOSIS reperfusion injury risk factors RNA THERAPEUTICS

Current innovations in head and neck cancer:From diagnostics to therapeutics: 《Oncology Research》2025年第5期1019-1032,共14页TAYYABA SATTAR IQRA NAZIR MEHREEN JABBAR JAVARIA MALIK SABA AFZAL SANA HANIF SEYED ALI MOSADDAD AHMED HUSSAIN HAMID TEBYANIYAN; Background:Head and neck cancers(HNC)account for a significant global health burden,with increasing incidence rates and complex treatment requirements.Traditional diagnostic and therapeutic approaches,while effective,...; 关键词：Head and neck cancer(HNC) DIAGNOSTICS THERAPEUTICS Innovations

Cellular therapeutics and immunotherapies in wound healing-on the pulse of time?: 《Military Medical Research》2025年第2期242-263,共22页Lioba Huelsboemer Leonard Knoedler Alejandro Kochen Catherine T.Yu Helia Hosseini Katharina S.Hollmann Ashley E.Choi Viola A.Stögner Samuel Knoedler Henry C.Hsia Bohdan Pomahac Martin Kauke-Navarro; supported by grants from the German Research Foundation (DFG); Chronic,non-healing wounds represent a significant challenge for healthcare systems worldwide,often requiring significant human and financial resources.Chronic wounds arise from the complex interplay of underlying com...; 关键词：Chronic wounds Wound healing Wound healing disorder BIOFILM IMMUNOTHERAPIES Cellular therapies

Quorum quenching enzymes disrupt bacterial communication in a sex-and dose-dependent manner: 《Animal Models and Experimental Medicine》2025年第3期473-482,共10页Aneesh Syal Maria Martell Rakesh Sikdar Matthew Dietz Zachary Ziegert Cyrus Jahansouz Mikael H.Elias Christopher Staley; Biotechnology Institute and the MnDrive initiative(to MHE)。; Background:Over the past 50 years,the incidence of obesity has gradually increased,necessitating investigation into the multifactorial contributors to this disease,including the gut microbiota.Bacteria within the huma...; 关键词：MICROBIOME microbiota therapeutics obesity quorum sensing

Exploring the expensive therapeutic potential and clinical applications of viruses severe acute respiratory syndrome(SARS)-COV-2: 《Life Research》2025年第1期6-15,共10页Abdul Bari Hejran Atiqullah Sarwari Mohammad Hassan Hassand Abdul Wahid Monib Parwiz Niazi Abdul Qadeer Baseer Sayedwali Sediqi Uzair Mohammad Kakar; In this review research,the full bio-medical potential and application of the severe acute respiratory syndrome(SARS)-CoV-2 viruses are discussed in detail with the aim of discovering innovative treatment strategies i...; 关键词：virus-based therapeutics SARS-CoV-2 repurposing clinical applications therapeutic potential TARGETED antiviral strategies medical interventions

Mitochondrial therapeutics and mitochondrial transfer for neurodegenerative diseases and aging: 《Neural Regeneration Research》2025年第3期794-796,共3页Neville Ng Michelle Newbery Nicole Miles Lezanne Ooi; supported by a MAWA Project Grant(to NN,MN,LO)。; Mitochondrial dysfunction and neurodegeneration:Progressive neurodegenerative diseases affect a significant proportion of the population;in a single year,there are as many as 276 million disabilities and 9 million dea...; 关键词：DEGENERATIVE DISEASES MITOCHONDRIAL

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics: 《Nano-Micro Letters》2025年第2期463-497,共35页Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi Yin Ming Yang Xuxu Chen Xinhua Yin Yunlei Zhou; support of the National Natural Science Foundation of China(Grant No.52205593);Shaanxi Natural Science Foundation Project(2024JC-YBMS-711).; The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing capability.Endogenous bioelectrical ...; 关键词：Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

THERAPEUTICS