IMMUNOTHERAPIES

作品数：43被引量：76H指数：4
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Cellular therapeutics and immunotherapies in wound healing-on the pulse of time?
《Military Medical Research》2025年第2期242-263,共22页Lioba Huelsboemer Leonard Knoedler Alejandro Kochen Catherine T.Yu Helia Hosseini Katharina S.Hollmann Ashley E.Choi Viola A.Stögner Samuel Knoedler Henry C.Hsia Bohdan Pomahac Martin Kauke-Navarro 
supported by grants from the German Research Foundation (DFG)
Chronic,non-healing wounds represent a significant challenge for healthcare systems worldwide,often requiring significant human and financial resources.Chronic wounds arise from the complex interplay of underlying com...
关键词：Chronic wounds Wound healing Wound healing disorder BIOFILM IMMUNOTHERAPIES Cellular therapies 
T helper 17 cells and interleukin-17 immunity in type 1 diabetes:From pathophysiology to targeted immunotherapies
《World Journal of Diabetes》2025年第4期48-61,共14页Georgi Vasilev Maria Kokudeva Elina Siliogka Nathalia Padilla Russka Shumnalieva David Della-Morte Camillo Ricordi Antoaneta Mihova Marco Infante Tsvetelina Velikova 
Supported by the European Union-NextGenerationEU,through the National Recovery and Resilience Plan of the Republic of Bulgaria,No.BG-RRP-2.004-0008.
Type 1 diabetes(T1D)is a chronic organ-specific autoimmune disorder characterized by a progressive loss of the insulin-secreting pancreatic beta cells,which ultimately results in insulinopenia,hyperglycemia and lifelo...
关键词：Type 1 diabetes T helper 17 cells INTERLEUKIN-17 T helper 1 cells Regulatory T cells Anti-interleukin-17 treatment Th17-targeted treatment 
Advances and prospects of RNA delivery nanoplatforms for cancer therapy
《Acta Pharmaceutica Sinica B》2025年第1期52-96,共45页Mohamed S.Attia Gregor Kijanka Nam-Trung Nguyen Jun Zhang Hongjie An 
support from the Australian Research Council Future Fellowship(No.FT180100361,Australia);Discovery Project(No.DP230100556,Australia);support from Australian Laureate Fellowship(FL230100023,Australia).
Modern oncology is rapidly evolving,driven by recent advances in RNA-based therapeutics.As new emerging cutting-edge technology,mRNA vaccines hold excellent promise for encoding immunostimulatory molecules,tumor-assoc...
关键词：Cancer therapy mRNA vaccine RNAINTERFERENCE Nanoplatforms Gene delivery IMMUNOTHERAPIES Gene silencing Neoantigens 
Osteoimmunology in bone malignancies:a symphony with evil
《Journal of the National Cancer Center》2024年第4期354-368,共15页Churui Song Tie Tong Biqi Dai Yue Zhu Elina Chen Min Zhang Weijie Zhang 
supported by the Fundamental Research Funds for the Zhejiang Provin-cial Universities(grant number:2023QZJH60);the Science Fund Pro-gram for Distinguished Young Scholars from the National Natural Science Foundation of China(grant number:588020-X42306/041);the startup fund from the Life Sciences Institute of Zhejiang University to W.Z.
Bone marrow is pivotal for normal hematopoiesis and immune responses,yet it is often compromised by malig-nancies.The bone microenvironment(BME),composed of bone and immune cells,maintains skeletal integrity and blood...
关键词：Bone metastasis OSTEOSARCOMA OSTEOIMMUNOLOGY Bone microenvironment IMMUNOTHERAPIES 
Complex role of neutrophils in the tumor microenvironment: an avenue for novel immunotherapies
《Cancer Biology & Medicine》2024年第10期849-863,共15页Mao Zhang Haokai Qin Yingcheng Wu Qiang Gao 
supported by the National Natural Science Foundation of China(Grant Nos.82130077,81961128025,and 82121002);the Research Projects from the Science and Technology Commission of Shanghai Municipality(Grant Nos.21JC1401200,20JC1418900,and 21JC1410100)to QG,the China National Postdoctoral Program for Innovative Talents(Grant No.BX20240090);the China Postdoctoral Science Foundation(Grant No.2024M750551)to MZ.
Neutrophils,which originate from the bone marrow and are characterized by a segmented nucleus and a brief lifespan,have a crucial role in the body’s defense against infections and acute inflammation.Recent research h...
关键词：NEUTROPHIL PLASTICITY tumor microenvironment IMMUNOTHERAPY 
The unique immune evasion mechanisms of the mpox virus and their implication for developing new vaccines and immunotherapies
《Virologica Sinica》2024年第5期709-718,共10页Dong Fang Yan Liu Dou Dou Bin Su 
supported by the High-Level Public Health Specialized Talents Project of Beijing Municipal Health Commission(2022-2-018 to B.S.);Beijing Key Laboratory for HIV/AIDS Research(BZ0089).The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.
Mpox is an infectious and contagious zoonotic disease caused by the mpox virus(MPXV),which belongs to the genus Orthopoxvirus.Since 2022,MPXV has posed a significant threat to global public health.The emergence of thou...
关键词：Immune response Immune evasion Mpox virus(MPXV) IMMUNOPATHOLOGY DNA sensing 
Nano-Bacillus Calmette-Guérin immunotherapies for improved bladder cancer treatment
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第7期557-567,共11页Sheng ZENG Shaoqiang XING Yifei ZHANG Haifeng WANG Qian LIU 
supported by the Tianjin Natural Science Foundation(Nos.21JCYBJC00220 and 22JCQNJC01640);the Tianjin Health Science and Technology Project(No.ZC20162);the Tianjin Key Medical Discipline(Specialty)Construction Project,and the National Natural Science Foundation of China(No.82202323).
Cancer immunotherapy has rapidly become the fourth mainstream treatment alternative after surgery,radiotherapy,and chemotherapy,with some promising results.It aims to kill tumor cells by mobilizing or stimulating cyto...
关键词：Bladder cancer Bacillus Calmette-Gué rin vaccine NANOCARRIER Genetic engineering Immunotherapy 
Development of NK cell-based cancer immunotherapies through receptor engineering被引量：4
《Cellular & Molecular Immunology》2024年第4期315-331,共17页Audrey Page Nicolas Chuvin Jenny Valladeau-Guilemond Stéphane Depil 
The AP postdoctoral position is funded by INCa PLBio 2020-095.
Natural killer(NK)cell-based immunotherapies are attracting increasing interest in the field of cancer treatment.Early clinical trials have shown promising outcomes,alongside satisfactory product efficacy and safety.R...
关键词：NK cells Cell therapy Receptor engineering CAR 
Boosting synergism of chemo- and immunotherapies via switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis by bisphosphonate coordination lipid nanogranules被引量：1
《Acta Pharmaceutica Sinica B》2024年第2期836-853,共18页Ge Song Minghui Li Shumin Fan Mengmeng Qin Bin Shao Wenbing Dai Hua Zhang Xueqing Wang Bing He Qiang Zhang 
supported by National Key Research and Development Program (2022YFA1206100, China);Natural Science Foundation of Beijing Municipality (L212013, China);AI+Health Collaborative Innovation Cultivation Project (Z211100003521002,China);National Natural Science Foundation of China(82073786, 81872809, U20A20412, 81821004)
Conventional chemotherapy based on cytotoxic drugs is facing tough challenges recently following the advances of monoclonal antibodies and molecularly targeted drugs.It is critical to inspire new potential to remodel ...
关键词：Bisphosphonate coordinationlipid nanogranules Ferroptosis Mevalonatemetabolism Mitochondrial metabolism Nano-systematic biology 
In situ immunomodulation of tumors with biosynthetic bacteria promote anti-tumor immunity被引量：1
《Bioactive Materials》2024年第2期12-27,共16页Zhongda Lin Fanqiang Meng Yumeng Ma Chi Zhang Zhirang Zhang Zhaoxin Yang Yuan Li Linlin Hou Yuzhong Xu Xin Liang Xudong Zhang 
supported by grants from Shenzhen Science and Technology Program(Grant No.RCYX20200714114643121);The National Natural Science Foundation of China(31971268,32201084,32371425);Science,Technology&Innovation Commission of Shenzhen Municipality(JCYJ20200109142610136,JCYJ20180507181654186,ZDSYS20220606100803007);Guangdong Basic and Applied Basic Research Foundation(2019A1515010855,2020A1515110166);the Natural Science Foundation of Guangdong Province(No.2020A1515010802,No.2022A1515012289);University of Chinese Academy of Sciences-Shenzhen Hospital Research Funding(HRF-2020004);the Health system scientific research project of Shenzhen Guangming District Science and innovation Bureau(2020R01073,2020R01061);Fundamental Research Funds for the Central Universities(19lgzd453);Special fund for economic development of ShenZhen Guangming District(2021R01128);Doctoral personnel scientific research start-up Fund project of Guangdong Medical University(GDMUB2022037).
Immune checkpoint blockade(ICB)therapy potently revives T cell’s response to cancer.However,patients suffered with tumors that had inadequate infiltrated immune cells only receive limited therapeutic benefits from IC...
关键词：SALMONELLA GM-CSF IL-7 Synthetic biology Cancer immunotherapies 
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