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The unique immune evasion mechanisms of the mpox virus and their implication for developing new vaccines and immunotherapies: 《Virologica Sinica》2024年第5期709-718,共10页Dong Fang Yan Liu Dou Dou Bin Su; supported by the High-Level Public Health Specialized Talents Project of Beijing Municipal Health Commission(2022-2-018 to B.S.);Beijing Key Laboratory for HIV/AIDS Research(BZ0089).The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.; Mpox is an infectious and contagious zoonotic disease caused by the mpox virus(MPXV),which belongs to the genus Orthopoxvirus.Since 2022,MPXV has posed a signiﬁcant threat to global public health.The emergence of thou...; 关键词：Immune response Immune evasion Mpox virus(MPXV) IMMUNOPATHOLOGY DNA sensing

Physiological strategies in wild rodents:immune defenses of commensal rats被引量：1: 《Integrative Zoology》2024年第3期350-370,共21页Ivana MIRKOV Dina TUCOVIC Jelena KULAS Anastasija MALESEVIC Dragan KATARANOVSKI Milena KATARANOVSKI Aleksandra POPOV ALEKSANDROV; supported by the Ministry of Education,Science and Technological Development of the Republic of Serbia(451-03-68/2022-14/200007).; The importance of issues associated with urban/commensal rats and mice(property damage,management costs,and health risks)press upon research on these animals.While the demography of commensal rodents is mostly studied...; 关键词：commensal rats and mice IMMUNOPATHOLOGY infection inflammation tolerance

Long chikungunya?An overview to immunopathology of persistent arthralgia: 《World Journal of Virology》2024年第2期48-57,共10页Jayme Euclydes Picasky Silveira-Freitas Maria Luiza Campagnolo Mariana dos Santos Cortez Fabrício Freire de Melo Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira; Chikungunya fever(CF)is caused by an arbovirus whose manifestations are extremely diverse,and it has evolved with significant severity in recent years.The clinical signs triggered by the Chikungunya virus are similar ...; 关键词：CHIKUNGUNYA IMMUNOPATHOLOGY Inflammation process Persistent arthralgia Signaling lymphocytic activation molecule family member 7

Understanding the Pathogenesis of Generalized Pustular Psoriasis Based on Molecular Genetics and Immunopathology: 《International Journal of Dermatology and Venereology》2022年第4期199-206,共8页An-Qi Zhao Ming Li; Generalized pustular psoriasis(GPP)is a rare and life-threatening autoinflammatory skin disease characterized by recurrent and sudden episodes of widespread rashes with scattered sterile pustules.Clinical and genetic ...; 关键词：AUTOINFLAMMATION generalized pustular psoriasis GPP genetic mechanisms IL-36

ADAR1 mutation causes ZBP1-dependent immunopathology: 《四川生理科学杂志》2022年第7期1243-1243,共1页Nicholas W Hubbard; The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by disrupting the duplex structure of endogenou...; 关键词：ADAR1 ACTIVATION ALTERATION

STING,a critical contributor to SARS-CoV-2 immunopathology被引量：1: 《Signal Transduction and Targeted Therapy》2022年第4期958-960,共3页Heyu Li Fangfang Zhou Long Zhang; a special program from the Ministry of Science and Technology of China(2021YFA1101000);the Chinese National Natural Science Funds(31925013 and U20A20393 to L.Z.,31871405,32125016 and 82041009 to F.Z.);Zhejiang Provincial Natural Science Foundation of China under Grant(LBY21H060001 to L.Z.);the Medical and the Medical and Health Research Project of Zhejiang Province(2020RC115 to L.Z.);Jiangsu National Science Foundation(BK20180043 and 19KJA550003 to F.Z.);the Zhejiang Natural Science Fund(LD19C070001 to L.Z.);the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003);Adjunct Talent Fund of Zhejiang Provincial People's Hospital and A project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions。; Recently,a study published in Nature by Domizio et al.1 revealed the underlying mechanism of aberrant immunopathology during the late phase of infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)...; 关键词：INTERFERON STIMULATOR ACUTE

COVID-19,liver dysfunction and pathophysiology:A conceptual discussion: 《World Journal of Gastroenterology》2022年第6期683-688,共6页Jucier Gonçalves Júnior; The intra and extracellular pathways of hepatic injury by coronavirus disease 2019(COVID-19)are still being studied.Understanding them is important to treat this viral disease and other liver and biliary tract disorde...; 关键词：COVID-19 Intracellular signaling peptides and proteins IMMUNOPATHOLOGY Liver diseases Liver injury SARS-CoV-2

Current progress and challenges in the design and development of a successful COVID-19 vaccine被引量：1: 《Fundamental Research》2021年第2期139-150,共12页Tingting Li Tianying Zhang Ying Gu Shaowei Li Ningshao Xia; the National Natural Science Foundation of China(Grant Nos.81991491,81991495&82001756);the National Key Research and Development Project(Grant No.2020YFC0842600).; The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is still a worldwide concern,with little to no sign of a decreasing trend.There is a general consens...; 关键词：CORONAVIRUS SARS-CoV-2 COVID-19 VACCINE IMMUNOPATHOLOGY Immune response

The brain–immune cells axis controls tissue specific immunopathology: 《Cellular & Molecular Immunology》2019年第2期101-103,共3页Maxi Heyner Sarah Schreier Andrea Kröger; During viral infections,cell death can be induced as a direct result of cytopathic virus replication in various cell types and tissues or as an immune response of the host to the infectious agent.This leads to an infi...; 关键词：PREVENTION damage DEATH

The cytokine storm of severe influenza and development of immunomodulatory therapy被引量：82: 《Cellular & Molecular Immunology》2016年第1期3-10,共8页Qiang Liu Yuan-hong Zhou Zhan-qiu Yang; Severe influenza remains unusual in its virulence for humans. Complications or ultimately death arising from these infections are often associated with hyperinduction of proinflammatory cytokine production, which is a...; 关键词：cytokine storm IMMUNOMODULATION IMMUNOPATHOLOGY INFLUENZA THERAPY

IMMUNOPATHOLOGY