Current progress and challenges in the design and development of a successful COVID-19 vaccine  

作　　者：Tingting Li Tianying Zhang Ying Gu Shaowei Li Ningshao Xia 

机构地区：[1]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,School of Life Sciences,School of Public Health,Xiamen University,Xiamen 361102,China [2]National institute of Diagnostics and Vaccine Devdopment in infecrious Disease,xiamen University,Xiamen 361102,China

出　　处：《Fundamental Research》2021年第2期139-150,共12页自然科学基础研究（英文版）

基　　金：the National Natural Science Foundation of China(Grant Nos.81991491,81991495&82001756);the National Key Research and Development Project(Grant No.2020YFC0842600).

摘　　要：The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is still a worldwide concern,with little to no sign of a decreasing trend.There is a general consensus that normal life will be hampered until a safe and effective vaccine strategy is available and globally administered.Numerous countries have accelerated the clinical trials process for the development of a successful COVID-19 treatment,with over 200 candidates presently available for testing against SARS-CoV-2.Here,we provide an overview of the COVID-19 vaccine candidates currently in development,discuss the scientific and practical challenges associated with COVID-19 vaccine design,and share the potential strategies that could be exploited for vaccine design success.

关 键 词：CORONAVIRUS SARS-CoV-2 COVID-19 VACCINE IMMUNOPATHOLOGY Immune response 

分 类 号：R392[医药卫生—免疫学]