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COVID-19 Vaccine Distribution Patterns for Prioritized Age Group: Analysis of European Nations: 《Open Journal of Epidemiology》2025年第1期1-18,共18页Ogbonnaya Ezichi Victor Okpanachi Joy Jibunoh Wuraola Awosan Prosper Tchoumo Anthony Akande Chibuzor Amaechi Jubril Sanusi Funmilayo Ogunsanwo Rofiat Adesina; The emergence of the SARS-CoV-2 virus resulted in a health and economic crisis worldwide. Although everyone is susceptible to COVID-19, the elderly have compromised immune systems and often suffer from chronic underly...; 关键词：SARS-CoV-2 COVID-19 Vaccines Prioritized Age Group European Nations

An insect cell-derived extracellular vesicle-based gB vaccine elicits robust adaptive immune responses against Epstein-Barr virus: 《Science China(Life Sciences)》2025年第3期734-745,共12页Qian Wu Kaiyun Chen Wenhui Xue Guosong Wang Yanbo Yang Shaowei Li Ningshao Xia Yixin Chen; supported by the National Natural Science Foundation of China(82073756).; Epstein-Barr virus(EBV),the first identified human tumor virus,is implicated in various human malignancies,infectious mononucleosis,and more recently,multiple sclerosis.Prophylactic vaccines have the potential to effe...; 关键词：Epstein-Barr virus glycoprotein gB extracellular vesicle humoral immune responses cellular immune responses

Exploring the use of the 3C Model in the context of HPV vaccine hesitancy in women of childbearing age: 《Infectious Diseases Research》2025年第1期16-27,共12页Nan Jiang Kui-Mei Zhang Mei-Hua Wu Xiao-Lei Song Wei-Wei Sun Mei Wang Wen-Ming Cao; District of Medical and Health Research Project(2023JD212);Shenzhen Bao’an District of Traditional Chinese Medicine Clinical Research Project(2023ZYYLCZX-12);Shenzhen“Medical and Health Three Projects”Project Grant(SZZYSM 202106003);Weifang Health Committee Scientific Research Project(wfwsjk-2023-170);Shenzhen Pingshan District of Health System Research Project(2024334).; Bacckground:Based on the 3C model,this study explores the current situation of HPV vaccine hesitancy among women of childbearing age and the factors influencing vaccine hesitancy.Methods:Based on the free cervical can...; 关键词：HPV vaccine vaccine hesitancy 3C model

Advancements in Mpox Vaccine Development:A Comprehensive Review of Global Progress and Recent Data: 《Biomedical and Environmental Sciences》2025年第2期248-254,共7页Yuqian Zhai Yize Han Wenling Wang Wenjie Tan; Since May 2022,a severe global Mpox epidemic has underscored the urgent need for a preventative vaccine.On September 16,2022,the mainland of China reported its first case of imported Mpox,which was subsequently follow...; 关键词：Mpox vaccine Vaccinia virus Mpox virus Smallpox vaccine

Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses: 《Fundamental Research》2025年第1期183-191,共9页Liping Liu Jiayu Zhao Zichao Huang Yudi Xu Hongyu Chen Ruirui Qiao Wantong Song Zhaohui Tang Thomas P.Davis Xuesi Chen; supported by grants from the National Natural Science Foundation of China(22222509,51973215,52025035,52103194,22105199);the Ministry of Science and Technology of China(2022YFE0110200);Bureau of International Cooperation Chinese Academy of Sciences(121522KYSB20200029);Jilin Province Science and Technology Development Plan(YDZJ202101ZYTS131,20220402037GH);Jilin Provincial International Cooperation Key Laboratory of Biomedical Polymers(20210504001GH);Changchun Science and Technology Development Plan(21ZY09);the Youth Innovation Promotion Association of Chinese Academy of Sciences(2020232).; In recent years,the use of nanotechnologies to improve immunotherapy efficiency has attracted increasing interest in preventive and therapeutic cancer vaccine design.However,current nanocarriers are restricted by diff...; 关键词：Cancer immunotherapy Cancer vaccine NANOTECHNOLOGY Drug delivery BIOPOLYMER

Rethinking BCG vaccine delivery for enhanced efficacy:Are two distinct routes of BCG administration better than one?: 《hLife》2025年第2期61-63,共3页Raymond Moeketsi Moseki Melissa Dalcina Chengalroyen; supported by the Fogarty HIV-associated TB training Program Fellowship(to R.M.M.);the Faculty of Health Science Start Up Emerging Researcher Award(to M.D.C);supported by the Fogarty International Center of the National Institutes of Health and the Eunice Kennedy ShriverNational Institute of Child Health&Human Development(D43 TW010559).; Despite the availability of effective tuberculosis(TB)treatments,the extended duration of therapy poses significant challenges to patient adherence.Vaccination remains a significant public healthcare milestone and cou...; 关键词：CHEMOTHERAPY VACCINE SPITE

Exploring the role of cationic lipids in modulating immunogenicity and vaccine efficacy of mRNA-LNP: 《Particuology》2025年第2期1-11,共11页Yan Zhou Xiangfei Shan Renji Gu Yufei Xia Xiaonan Huang; This work was supported by National Key Research and Development Program of China(grant No.2021YFC2302400);Major Program of the National Natural Science Foundation of China(grant Nos.T2394503 and T2394501);CAS Project for Young Scientists in Basic Research(grant No.YSBR-010);Key Project of the National Natural Science Foundation of China(grant No.32030062);IPE Project for Frontier Basic Research(grant No.QYJC2023-04)。; The mRNA vaccines have become a transformative platform in medicine,with their success during the COVID-19 pandemic accelerating research in viral prevention and cancer therapy.Lipid nanoparticles(LNPs)enhance the sta...; 关键词：Lipid nanoparticle mRNA vaccine IMMUNOGENICITY Cationic lipids Immune response

Research progress on the non-coding region of single-stranded positive-sense RNA(+ssRNA)viruses: 《Journal of Chinese Pharmaceutical Sciences》2025年第1期1-13,共13页Liangrong Guo Guoyue Liu Ju Sun Dengguo Wei; National Key Research and Development Programs of China(Grant No.2021YFD1801102);the National Natural Science Foundation of China(Grant No.22077043,32473010);the Fundamental Research Funds for the Central Universities(2662023PY005 to DW);HZAU-AGIS Cooperation Fund(SZYJY2022016 to DW);Natural Science Foundation of Hubei Province(2021CFA061 to DW);the Funding from National Key Laboratory of Agricultural Microbiology(AML2023B05 to DW)。; Single-stranded positive-sense RNA(+ssRNA)viruses encompass a diverse range of species and exert profound effects on human and animal health,as well as agricultural economic productivity.The 5'and 3'untranslated regio...; 关键词：+ssRNAvirus UTR Structure VACCINE

Development of multi-epitope mRNA vaccine against Clostridioides difficile using reverse vaccinology and immunoinformatics approaches被引量：1: 《Synthetic and Systems Biotechnology》2024年第4期667-683,共17页Caixia Tan Yuanyuan xiao Ting Liu Siyao Chen Juan Zhou Sisi Zhang Yiran Hu Anhua Wu Chunhui Li; upported by the National Key Research and Development Program of China[No.2022YFC2009801,No.2022YFC2009805];the Natural Science Foundation of Hunan Province[No.2021JJ31071];the Project program of National Clinical Research Center for Geriatric Disorders(Xiangya Hospital)[No.2021KFJJ05];Health Development Research Center of the National Health Commission,"Evidence-based Evaluation and Demonstration Base Construction Project of Infection Control Measures in Healthcare Institutions"[No.CNHDRC-KJ-L-2020-53-04375];Scientific and technological personnel lifting Project in Hunan Province[No.2023 TJ-Z11].; Clostridioides difficile(C.difficile),as the major pathogen of diarrhea in healthcare settings,has become increasingly prevalent within community populations,resulting in significant morbidity and mortality.However,th...; 关键词：Clotridioides difficile(C.difficile) mRNA vaccine IMMUNOINFORMATICS Reverse vaccinology(RV) Molecular docking Molecular dynamics(MD)simulation

Next-generation mpox vaccines:efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates: 《Signal Transduction and Targeted Therapy》2024年第12期5364-5366,共3页Leonie Mayer Leonie M.Weskamm Marylyn M.Addo; funded by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)-SFB 1648/12024-512741711.; In a recent study published in Cell,Mucker et al.demonstrated in a non-human primate(NHP)model of lethal mpox virus(MPXV)infection,that a novel mRNA-based vaccine,as compared to modified vaccinia virus Ankara(MVA)stra...; 关键词：VACCINE protective al.

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