NIR-Ⅱ-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition  

作　　者：Yijian Gao Yachao Zhang Yujie Ma Xiliang Li Yu Wang Huan Chen Yingpeng Wan Zhongming Huang Weimin Liu Pengfei Wang Lidai Wang Chun-Sing Lee Shengliang Li 

机构地区：[1]College of Pharmaceutical Sciences,the Fourth Affiliated Hospital of Soochow University,Suzhou Medical College,Soochow University,Suzhou 215123,China [2]Key Laboratory of Biomedical Imaging Science and System,Suzhou Institute of Biomedical Engineering and Technology,Chinese Academy of Sciences,Suzhou 215163,China [3]Center of Super-Diamond and Advanced Films(COSDAF),Department of Chemistry,City University of Hong Kong,Hong Kong SAR 999077,China [4]Department of Biomedical Engineering,City University of Hong Kong,Hong Kong SAR,China [5]Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China [6]Joint Laboratory of Nano-organic Functional Materials and Devices(TIPC and CityU),City University of Hong Kong,Hong Kong SAR 999077,China

出　　处：《Acta Pharmaceutica Sinica B》2025年第2期1159-1170,共12页药学学报(英文版)

基　　金：upported by the National Natural Science Foundation of China(No.52173135);the Natural Science Foundation of Jiangsu Province(No.BK20231523,China);Jiangsu Specially Appointed Professorship,Leading Talents of Innovation and Entrepreneurship of Gusu(ZXL2022496,China);and the Suzhou Science and Technology Program(SKY2022039,China);Chun-Sing Lee thanks the support of the Research Grants Council of Hong Kong Special Administrative Region,General Research Fund(No.CityU 11300320,11318322,China);Prof.Lidai Wang acknowledges support from the National Natural Science Foundation of China(No.81627805);the Research Grants Council of the Hong Kong Special Administrative Region(21205016,11215817,11101618,China).

摘　　要：High-performance phototheranostics with combined photothermal therapy and photoacoustic imaging have been considered promising approaches for efficient cancer diagnosis and treatment.However,developing phototheranostic materials with efficient photothermal conversion efficiency(PCE),especially over the second near-infrared window(NIR-Ⅱ,1000-1700 nm),remains challenging.Herein,we report an ultraefficient NIR-Ⅱ-activated nanomedicine with phototheranostic and vaccination capability for highly efficient in vivo tumor elimination and metastasis inhibition.The NIR-Ⅱnanomedicine of a semiconducting biradical oligomer with a motor-flexible design was demonstrated with a record-breaking PCE of 87%upon NIR-Ⅱexcitation.This nanomedicine inherently features extraordinary photothermal stability,good biocompatibility,and excellent photoacoustic performance,contributing to high-contrast photoacoustic imaging in living mice and high-performance photothermal elimination of tumors.Moreover,a whole-cell vaccine based on a NIR-Ⅱnanomedicine with NIR-Ⅱ-activated performance was further designed to remotely activate the antitumor immunologic memory and effectively inhibit tumor occurrence and metastasis in vivo,with good biosafety.Thus,this work paves a new avenue for designing NIR-Ⅱactive semiconducting biradical materials as a promising theranostics platform and further promotes the development of NIR-Ⅱnanomedicine for personalized cancer treatment.

关 键 词：NIR-Ⅱ Semiconducting oligomer Photothermal therapy VACCINE Nanoparticles THERANOSTICS Breast carcinoma Immunotherapy 

分 类 号：R73[医药卫生—肿瘤]