INTERFERON

作品数：628被引量：1864H指数：18
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Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration
《Neural Regeneration Research》2025年第7期2005-2007,共3页Bryan Sun Lulin Li Jian Luo 
partially supported by a grant(RF1AG059694)from the U.S.National Institutes of Health;by Polytrauma System of Care,VAPAHCS(to JL)。
The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of neuroinflammation.While current studies primarily attribute its effects to neurons and glial ce...
关键词：STIMULATOR INTERFERON inflammation 
Intralesional and topical treatments for Peyronie’s disease:a narrative review of current knowledge
《Asian Journal of Andrology》2025年第2期156-165,共10页Antonio Minore Loris Cacciatore Fabrizio Presicce Andrea Iannuzzi Antonio Testa Gianluigi Raso Rocco Papalia Marco Martini Roberto Mario Scarpa Francesco Esperto 
Peyronie’s disease(PD)presents a multifaceted challenge in contemporary urological practice,marked by penile deformity,pain,and the potential for erectile dysfunction.We meticulously explored the existing literature ...
关键词：COLLAGENASE induratio penis plastic INTERFERON intralesional/topical treatments penile traction Peyronie’s disease 
Context-dependent role of sirtuin 2 in inflammation被引量：1
《Neural Regeneration Research》2025年第3期682-694,共13页NoemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado Elena Puerta 
funded by FEDER/Ministerio de Ciencia,Innovación y Universidades Agencia Estatal de Investigación/Project(PID2020-119729GB-100,REF/AEI/10.13039/501100011033)(to EP);a predoctoral fellowship from the Spanish Ministry of Universities(FPU)and Amigos de la Universidad de Navarra(to NSS);“Programa MRR Investigo 2023”(to MGB and MMD)。
Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has...
关键词：INTERFERON INFLAMMATION LIPOPOLYSACCHARIDE NEUROINFLAMMATION NLRP3 nuclear factorκB sirtuin 2 
Regulation of human interferon signaling by transposon exonization
《四川生理科学杂志》2024年第12期2607-2607,共1页Giulia Irene Maria Pasquesi 
Innate immune signaling is essential for clearing pathogens and damaged cells and must be tightly regulated to avoid excessive inflammation or autoimmunity.Here,we found that the alternative splicing of exons derived ...
关键词：controlling DECOY finding 
Clinical features of nontuberculous mycobacteria disease patients with positive antiinterferon autoantibody
《China Medical Abstracts(Internal Medicine)》2024年第4期205-206,共2页QIN Zhijie 
Objective To investigate the clinical features of nontuberculous mycobacteria(NTM)disease patients with positive anti-interferon γ(IFN-γ)autoantibody.Methods Forty-three adult human immunodeficiency virus-uninfected...
关键词：PATIENTS INTERFERON CLINICAL 
Clinical efficacy of traditional Chinese medicine combined with Western medicine in the treatment of persistent human papillomavirus infection in patients with infertility
《Reproductive and Developmental Medicine》2024年第4期226-232,共7页Ling Yang Ting Zhang Yan Li Hong-Long Ma 
General Project of Changning District Science and Technology Committee, Shanghai(CNKW2020Y29);Key Project of Changning District Science and Technology Committee, Shanghai(CNKW2020Z04);Innovative Talent Base for Medical Doctors in Changning District, Shanghai(RCJD2021B09);Shanghai Natural Science Foundation(22ZR1458200);Natural Science Foundation of Shanghai, China(22ZR1458200);medical PhD Innovative Talent Base Project of Changing District, Shanghai, China(RCJD2021B09);Key Specialty of Changning District, Shanghai, China(20231004)。
Objective: To investigate the clinical efficacy of Fuzheng Jiedu formula combined with interferon in the treatment of human papillomavirus (HPV) infection in patients with infertility.Methods: A total of 750 infertile...
关键词：Fuzheng Jiedu formula INTERFERON INFERTILITY Human papillomavirus Persistent infection Spleen asthenia Dampness encumbrance 
Unlocking the novel activation mechanism of human IL-18
《Journal of Biomedical Research》2024年第5期448-450,共3页Yingchao Hu Yuxian Song Shuo Yang 
supported by the National Key Research and Development Program of China(Grant No.2022YFA1303900 to S.Y.);the National Natural Science Foundation of China(Grant Nos.32270921 and 82070567 to S.Y.,and 82204354 to Y.H.);the Open Project of State Key Laboratory of Reproductive Medicine of Nanjing Medical University(Grant No.SKLRM-2023A2 to S.Y.);the Talent Cultivation Project of"Organized Scientific Research"of Nanjing Medical University(Grant No.NJMURC20220014 to S.Y.);the Jiangsu Provincial Outstanding Postdoctoral Program(Grant No.2022ZB419 to Y.H.);the China Postdoctoral Science Foundation(Grant No.2023T160329 to Y.H.).
Interleukin(IL)-18,a member of the IL-1 family,is commonly known as an interferon-γinducer and is expressed in both hematopoietic and non-hematopoietic cells,such as intestinal epithelial cells,keratinocytes,and endo...
关键词：INTERFERON HEMATOPOIETIC INFLAMMATION 
Prognostic significance and underlying mechanisms of STING in lung adenocarcinoma
《Chinese Medical Journal》2024年第20期2501-2503,共3页Haohua Zhu Yufeng Cao Jingyu Lu Lei Guo Rongrong Luo Huiyang Shi Yu Feng Yutao Liu Puyuan Xing Hongyu Wang Yuankai Shi Jie Ma Xingsheng Hu 
founded by Beijing Xisike Clinical Oncology Research Foundation(No.Y-2019AZMS-0439).
To the Editor:Genomic instability is a hallmark of cancer,with increasing genetic changes and DNA damage.The accumulated mutations in the tumor genome can generate neoantigens,which can trigger an antitumor immune res...
关键词：INTERFERON STIMULATOR ADENOCARCINOMA 
Anti-infective immune functions of type Ⅳ interferon in grass carp(Ctenopharyngodon idella):A novel antibacterial and antiviral interferon in lower vertebrates
《Zoological Research》2024年第5期972-982,共11页Yuchen Liu Wentao Zhu Yanqi Zhang Jingjing Zhang Maolin Lv Jianguo Su 
supported by the Biological Breeding-Major Projects(2023ZD04065)。
Type Ⅳ interferon(IFN-υ)is a recently discovered cytokine crucial for host defense against viral infections.However,the role and mechanisms of IFN-υin bacterial infections remain unexplored.This study investigated ...
关键词：Grass carp(Ctenopharyngodon idella) IFN-υ Bactericidal activity Antiviral activity Antimicrobial immunity 
Oligodendrocytes in central nervous system diseases:the effect of cytokine regulation被引量：2
《Neural Regeneration Research》2024年第10期2132-2143,共12页Chengfu Zhang Mengsheng Qiu Hui Fu 
supported by the Natural Science Foundation of Zhejiang Province,No.LQ23C090003 (to CZ);the Major Project on Brain Science and Analog Brain Research of Ministry of Science and Technology of China,No.2022ZD0204701 (to MQ);the National Natural Science Foundation of China,No.32170969 (to MQ)。
Cytokines including tumor necrosis factor, interleukins, interferons, and chemokines are abundantly produced in various diseases. As pleiotropic factors, cytokines are involved in nearly every aspect of cellular funct...
关键词：ASTROCYTE central nervous system disease CXC chemokine cytokine interferonγ INTERLEUKIN MICROGLIA OLIGODENDROCYTE oligodendrocyte precursor cell tumor necrosis factorα 
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