Intralesional and topical treatments for Peyronie’s disease:a narrative review of current knowledge  

作　　者：Antonio Minore Loris Cacciatore Fabrizio Presicce Andrea Iannuzzi Antonio Testa Gianluigi Raso Rocco Papalia Marco Martini Roberto Mario Scarpa Francesco Esperto 

机构地区：[1]Department of Urology,Campus Bio-Medico,University of Rome,Rome 00128,Italy [2]Department of Urology,San Filippo Neri Hospital,Rome 00135,Italy

出　　处：《Asian Journal of Andrology》2025年第2期156-165,共10页亚洲男性学杂志(英文版)

摘　　要：Peyronie’s disease(PD)presents a multifaceted challenge in contemporary urological practice,marked by penile deformity,pain,and the potential for erectile dysfunction.We meticulously explored the existing literature of intralesional/topical interventions,aiming to provide clinicians with a nuanced understanding of available options for comprehensive PD management.To conduct this review,we performed a systematic search using the PubMed,Scopus,and ScienceDirect databases,including the keywords of combination of the“Peyronie’s disease/plastic induration of the penis(PIP)and intralesional/topical treatments”.The study selection was based on adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,resulting in the inclusion of 16 articles.We delve into the effectiveness and safety profiles of collagenase Clostridium histolyticum(CCH),interferon,platelet-rich plasma(PRP),hyaluronic acid,botulinum toxin,stem cell,extracorporeal shock wave therapy(ESWT),and traction therapy,assessing their impact on penile curvature,length improvement,and patient-reported symptoms and outcomes.The best options evaluated are intralesional injections of CCH and penile traction devices,alone or in combination.Despite PD remains a challenge for urologists,the objective of this review is to contribute to the evolving landscape of PD management,fostering informed decision-making,and personalized care for individuals grappling with this challenging condition.

关 键 词：COLLAGENASE induratio penis plastic INTERFERON intralesional/topical treatments penile traction Peyronie’s disease 

分 类 号：R697[医药卫生—泌尿科学]