Oligodendrocytes in central nervous system diseases:the effect of cytokine regulation  

作　　者：Chengfu Zhang Mengsheng Qiu Hui Fu 

机构地区：[1]Center for Cognition and Brain Disorders,The Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang Province,China [2]Department of Psychiatry,National Clinical Research Center for Mental Disorders,and National Center for Mental Disorders,The Second Xiangya Hospital of Central South University,Changsha,Hunan Province,China [3]Institute of Life Sciences,Key Laboratory of Organ Development and Regeneration of Zhejiang Province,College of Life and Environment Sciences,Hangzhou Normal University,Hangzhou,Zhejiang Province,China [4]Key Laboratory of Aging and Cancer Biology of Zhejiang Province,School of Basic Medical Sciences,Hangzhou Normal University,Hangzhou,Zhejiang Province,China

出　　处：《Neural Regeneration Research》2024年第10期2132-2143,共12页中国神经再生研究（英文版）

基　　金：supported by the Natural Science Foundation of Zhejiang Province,No.LQ23C090003 (to CZ);the Major Project on Brain Science and Analog Brain Research of Ministry of Science and Technology of China,No.2022ZD0204701 (to MQ);the National Natural Science Foundation of China,No.32170969 (to MQ)。

摘　　要：Cytokines including tumor necrosis factor, interleukins, interferons, and chemokines are abundantly produced in various diseases. As pleiotropic factors, cytokines are involved in nearly every aspect of cellular functions such as migration, survival, proliferation, and differentiation. Oligodendrocytes are the myelin-forming cells in the central nervous system and play critical roles in the conduction of action potentials, supply of metabolic components for axons, and other functions. Emerging evidence suggests that both oligodendrocytes and oligodendrocyte precursor cells are vulnerable to cytokines released under pathological conditions. This review mainly summarizes the effects of cytokines on oligodendrocyte lineage cells in central nervous system diseases. A comprehensive understanding of the effects of cytokines on oligodendrocyte lineage cells contributes to our understanding of central nervous system diseases and offers insights into treatment strategies.

关 键 词：ASTROCYTE central nervous system disease CXC chemokine cytokine interferonγ INTERLEUKIN MICROGLIA OLIGODENDROCYTE oligodendrocyte precursor cell tumor necrosis factorα 

分 类 号：R741[医药卫生—神经病学与精神病学]