ASTROCYTE

作品数:305被引量:941H指数:14
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相关领域:医药卫生更多>>
相关作者:刘海燕孙若鹏赵海军王芳黄超更多>>
相关机构:山东大学北京大学华中科技大学山东中医药大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>
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Metabolic reprogramming of astrocytes:Emerging roles of lactate
《Neural Regeneration Research》2026年第2期421-432,共12页Zeyu Liu Yijian Guo Ying Zhang Yulei Gao Bin Ning 
supported by the National Natural Science Foundation of China,Nos.82071383,82371392(to BN);the Natural Science Foundation of Shandong Province of China(Key Project),No.ZR2020KH007(to BN);“Taishan Scholar Distinguished Expert Program”of Shandong Province,No.tstp20231257(to BN);Health Commission Science and Technology Plan Project of Jinan,No.2023-1-8(to YZ).
Lactate serves as a key energy metabolite in the central nervous system,facilitating essential brain functions,including energy supply,signaling,and epigenetic modulation.Moreover,it links epigenetic modifications wit...
关键词:ASTROCYTE epigenetic modifications inflammation LACTATE lactylation METABOLIC PLASTICITY regeneration treatment 
Epilepsy therapy beyond neurons: Unveiling astrocytes as cellular targets
《Neural Regeneration Research》2026年第1期23-38,共16页Yuncan Chen Jiayi Hu Ying Zhang Lulu Peng Xiaoyu Li Cong Li Xunyi Wu Cong Wang 
supported by the National Key Research and Development Program of China,No. 2023YFF0714200 (to CW);the National Natural Science Foundation of China,Nos. 82472038 and 82202224 (both to CW);the Shanghai Rising-Star Program,No. 23QA1407700 (to CW);the Construction Project of Shanghai Key Laboratory of Molecular Imaging,No. 18DZ2260400 (to CW);the National Science Foundation for Distinguished Young Scholars,No. 82025019 (to CL);the Greater Bay Area Institute of Precision Medicine (Guangzhou)(to CW)。
Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the ...
关键词:ASTROCYTE cellular microenvironment drug resistance EPILEPSY EXCITABILITY homeostasis metabolism neural networks NEUROINFLAMMATION neuron 
Hidden face of Parkinson's disease:Is it a new autoimmune disease?
《Neural Regeneration Research》2026年第1期57-61,共5页Min Gi Jo Seon-Hee Kim Seung Pil Yun 
supported by the National Research Foundation of South Korea(2023R1A2C2004516,RS-2023-00219399 to SPY,and 2022R1I1A1A01063513 to MGJ)。
Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease is the ac...
关键词:ASTROCYTE autoimmune response biomarkers clinical implication major histocompatibility complex/human leukocyte antigen MICROGLIA neurodegenerative disease NEUROINFLAMMATION Parkinson's disease T cells Α-SYNUCLEIN 
Potential treatment of Alzheimer's disease astrocyte pathology based on nuclear lipid regulation
《Neural Regeneration Research》2026年第1期322-323,共2页Masato Komai Nobumasa Takasugi 
supported by a grant from the Japan Foundation for applied enzymology (to NT);the Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science (26430059, 17K08272, and 20K07014 to NT);the establishment of university fellowships toward the creation of science technology innovation (JPMJFS2128);a Grant-in-Aid for JSPS Fellows (23KJ1603)(to MK)。
The purpose of this perspective is to discuss the future development of a potential treatment of glial pathology in Alzheimer's disease(AD) and a new regulatory mechanism, nuclear lipids, which may be involved in the ...
关键词:PATHOLOGY ALZHEIMER 
Functional abnormalities of the glymphatic system in cognitive disorders
《Neural Regeneration Research》2025年第12期3430-3447,共18页Wuyue Shentu Qi Kong Yier Zhang Wenyao Li Qiulu Chen Sicheng Yan Junjun Wang Qilun Lai Qi Xu Song Qiao 
supported by Zhejiang Provincial Medical and Health Science and Technology Project,Nos.2022KY008(to JW),2023KY001(to JW),2023KY006(to QL);Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project,No.2023ZL220(to QL)。
Various pathological mechanisms represent distinct therapeutic targets for cognitive disorders,but a balance between clearance and production is essential for maintaining the stability of the brain's internal environm...
关键词:AQUAPORIN-4 ASTROCYTE cerebrospinal fluid dynamics cognitive disorders glymphatic system 
The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease
《Neural Regeneration Research》2025年第11期3330-3344,共15页Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha 
supported by the Research Foundation for Talented Scholars of Fujian Medical University,No.XRCZX2018014(to DZ);Startup Fund for Scientific Research,Fujian Medical University,No.2019QH1017(to CW);the Natural Science Foundation of Fujian Province,China,Nos.2021J01693(to DZ),2021J02032(to ZCY)。
Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregati...
关键词:Alzheimer's disease amyloid-β ASTROCYTE cognitive impairment D30 dendritic spines GALECTIN-3 MICROGLIA NEUROINFLAMMATION neuron 
Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology
《Neural Regeneration Research》2025年第9期2655-2666,共12页Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang 
supported by the National Key R&D Program of China,No.2021YFA0805200(to SY);the National Natural Science Foundation of China,No.31970954(to SY);two grants from the Department of Science and Technology of Guangdong Province,Nos.2021ZT09Y007,2020B121201006(both to XJL)。
Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto r.The mutant androgen r...
关键词:androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model NEURODEGENERATION neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor 
Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state
《Neural Regeneration Research》2025年第7期2008-2010,共3页Elena Ambrosini Angela Lanciotti Maria Stefania Brignone 
supported by funds from the Italian Ministry of Health,Ricerca Finalizzata,(Grant N.GR-2013-02355882 and GR-2021-12373946 to AL);5x1000 Project of the Istituto Superiore di Sanità(Project code:ISS5x1000_21-949432e8c9be to AL);the European Union–NextGeneration EU through the Italian Ministry of University and Research under PNRR-M4C2-I1.3 Project PE_00000019“HEAL ITALIA”to EA(CUP I83C22001830006)。
Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental...
关键词:alterations MODULATOR MAINTAIN 
Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2
《Neural Regeneration Research》2025年第6期1801-1815,共15页Qing He Zhen Wang Yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu Gong Chen 
supported by the Key Project of Guangzhou City,No.202206060002;Science and Technology Project of Guangdong Province,No.2018B030332001;Guangdong Provincial Pearl River Project,No.2021ZT09Y552 (all to GC)。
Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders....
关键词:AQUAPORIN-4 Ascl1 ASTROCYTE cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 REPROGRAMMING 
Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury被引量:2
《Neural Regeneration Research》2025年第4期973-989,共17页María Belén Cieri Alberto Javier Ramos 
supported by grants PICT 2019-0851;2017-2203,UBACYT and PIP CONICET(to AJR).
Traumatic brain injury is a global health crisis,causing significant death and disability worldwide.Neuroinflammation that follows traumatic brain injury has serious consequences for neuronal survival and cognitive im...
关键词:ASTROCYTE glial scar innate immunity NEUROINFLAMMATION stab injury Toll-like receptors 
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