EPILEPSY

作品数：786被引量：1111H指数：13
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相关作者：熊志奇岳旺王蕾张芳陈迁更多>>
相关机构：首都医科大学复旦大学中国科学院上海生命科学研究院青岛大学更多>>
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Epilepsy therapy beyond neurons: Unveiling astrocytes as cellular targets
《Neural Regeneration Research》2026年第1期23-38,共16页Yuncan Chen Jiayi Hu Ying Zhang Lulu Peng Xiaoyu Li Cong Li Xunyi Wu Cong Wang 
supported by the National Key Research and Development Program of China,No. 2023YFF0714200 (to CW);the National Natural Science Foundation of China,Nos. 82472038 and 82202224 (both to CW);the Shanghai Rising-Star Program,No. 23QA1407700 (to CW);the Construction Project of Shanghai Key Laboratory of Molecular Imaging,No. 18DZ2260400 (to CW);the National Science Foundation for Distinguished Young Scholars,No. 82025019 (to CL);the Greater Bay Area Institute of Precision Medicine (Guangzhou)(to CW)。
Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the ...
关键词：ASTROCYTE cellular microenvironment drug resistance EPILEPSY EXCITABILITY homeostasis metabolism neural networks NEUROINFLAMMATION neuron 
Investigation of epilepsy-related genes in a Drosophila model
《Neural Regeneration Research》2026年第1期195-211,共17页Xiaochong Qu Xiaodan Lai Mingfeng He Jinyuan Zhang Binbin Xiang Chuqiao Liu Ruina Huang Yiwu Shi Jingda Qiao 
supported by the Guangdong Basic and Applied Basic Research Foundation,No.2022A1515111123(to JQ)。
Complex genetic architecture is the major cause of heterogeneity in epilepsy,which poses challenges for accurate diagnosis and precise treatment.A large number of epilepsy candidate genes have been identified from cli...
关键词：Drosophila melanogaster ELECTROPHYSIOLOGY EPILEPSY GENETICS morphology neurogenetic diseases POLYGENE precision medicine seizure behavior UAS/GAL4 system 
Context-dependency in medicine:how neuronal excitability influences the impact of dopamine on cognition
《Neural Regeneration Research》2025年第11期3225-3226,共2页Mahboubeh Ahmadi Nahid Rouhi Javad Mirnajafi-Zadeh Bechara J.Saab 
Dopamine,often termed the"feel-good"neurotransmitter,plays a crucial role in myriad physiological and psychological brain processes.While dopamine is primarily associated with pleasure,reward,and motivation,its effect...
关键词：DOPAMINE EPILEPSY primarily 
The complex role of protocadherin-19 in brain function:a focus on the oxytocin system
《Neural Regeneration Research》2025年第11期3211-3212,共2页Sara Mazzoleni Marta Busnelli Silvia Bassani 
supported by a grant from Telethon Foundation(grant No.GGP20056 to SB);The generation of Pcdh19 floxed mouse model was funded by Cariplo Foundation(grant No.2014-0972 to SB)。
Mutations in the protocadherin-19(PCDH19)gene(Xq22.1)cause the X-linked syndrome known as developmental and epileptic encephalopathy 9(DEE9,OMIM#300088)(Dibbens et al.,2008).DEE9 is characterized by early-onset cluste...
关键词：EPILEPSY FUNCTION SYSTEM 
Unraveling the nutritional challenges in epilepsy:Risks,deficiencies,and management strategies:A systematic review
《World Journal of Experimental Medicine》2025年第2期200-245,共46页Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi 
BACKGROUND Malnutrition and epilepsy share a complex bidirectional relationship,with malnutrition serving as a potential risk factor for epilepsy development,while epilepsy,in turn,often exerts profound effects on nut...
关键词：EPILEPSY Nutritional management Seizure disorders Antiepileptic drugs MINERALS L-CARNITINE VITAMINS Omega-3 Gut microbiota 
The role of axon guidance molecules in the pathogenesis of epilepsy
《Neural Regeneration Research》2025年第5期1244-1257,共14页Zheng Liu Chunhua Pan Hao Huang 
supported by the National Natural Science Foundation of China,Nos. 81760247, 82171450;the Scientific Research Foundation for Doctors of the Affiliated Hospital of Zunyi Medical University,No.(2016)14 (all to HH)。
Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target no...
关键词：axon guidance drug-resistant epilepsy EPILEPSY nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity NEURONS synaptic remodeling 
A rare case of MELAS syndrome caused by mitochondrial DNA m.3256C>T mutation in China
《World Journal of Emergency Medicine》2025年第2期180-182,共3页Xiangxin Zheng Man Huang 
Mitochondrial cytopathies are characterized by energy failure within the cellular system.These disorders exhibit a wide range of clinical presentations and are highly heterogeneous.The mitochondrial diseases include m...
关键词：MELAS EPILEPSY clinical 
Activation of glutamine synthetase(GS)as a new strategy for the treatment of major depressive disorder and other GS-related diseases
《Acta Pharmacologica Sinica》2025年第4期880-891,共12页Jae Soon Kang Hwajin Kim Ji Hyeong Baek Miyoung Song Hyeongchan Park Wonjune Jeong Hye Jin Chung Dae Young Yoo Dong Kun Lee Sang Won Park Hyun Joon Kim 
supported by the National Research Foundation(NRF)(Grant numbers NRF-2021R1A5A802949012 and 2022R1A2C100529611);the Commercializations Promotion Agency for R&D Outcomes(COMPA)(Grant number 1711173796)funded by the Ministry of Science and ICT(MSIT)of the Korean government.
Glutamine synthetase(GS)plays a crucial role in the homeostasis of the glutamate–glutamine cycle in the brain.Hypoactive GS causes depressive behaviors.Under chronic stress,GS has no change in expression,but its acti...
关键词：depression glutamine synthetase tyrosine nitration tyrosine-containing dipeptide EPILEPSY HYPERAMMONEMIA 
Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies被引量：2
《Neural Regeneration Research》2025年第4期917-935,共19页Dian Jiao Lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu 
supported by the National Natural Science Foundation of China,No.32130060(to XG).
Epilepsy is a severe,relapsing,and multifactorial neurological disorder.Studies regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of epilepsy.The ...
关键词：DIAGNOSIS drug treatment ELECTROENCEPHALOGRAPHY epilepsy monitoring EPILEPSY nerve regeneration NEUROSTIMULATION non-drug interventions PATHOGENESIS prediction 
De novo missense variants of UNC13A are implicated in epileptic encephalopathies and neurodevelopmental disorders
《Genes & Diseases》2025年第2期52-56,共5页Ke Su Yu Ma Mingshan Zhou Yihan Liu Chengjie Li Yonghui Jiang Qihui Wu Gang Peng Yi Wang Shaohua Fan 
supported by the National Key Research and Development Program of China (No.2020YFE0201600,2021YFC2500202 to S.F.,2018YFA0801000 to G.P.);the National Natural Science Foundation of China (No.31970563,32370686 to S.F.,82101486 to Q.W.);the China's 111 Project (No.B13016 to S.F.);the Shanghai Municipal Science and Technology Commission (China) (No.19410741100 to S.F.);the Science and Technology Innovation Plan of Shanghai Science and TechnologyCommission (China) (No.22ZR1414000 to G.P.);the Shanghai Municipal Science and Technology Major Project (No.2018SHZDZX01 to G.P.,2017SHZDZX01 to S.F.);ZJ Lab,and the Shanghai Center for Brain Science and Brain-lnspired Technology (China);the Shanghai Fourth People's Hospital affiliated to Tongji University School of Medicine (No.sykyqd02301 to Q.W.);the Fundamental Research Funds for the Central Universities (China);the Shanghai Pujiang Program (China) (No.21PJ1412100 to Q.W.);the Ningxia Hui Autonomous Region Key Research and Development Project (China) (No.2022BFH02012 to Q.W.);the Science and Technology Commissionof ShanghaiMunicipality,China (No.23ZR1467900 to Q.W.).
Epilepsy is a prevalent and serious neurological disorder affecting more than 65 million individuals worldwide.The etiology of epilepsy is multifaceted,with genetic factors implicated in 70%-80%of epilepsy cases,based...
关键词：EPILEPSY ETIOLOGY CASES 
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