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Activation of glutamine synthetase(GS)as a new strategy for the treatment of major depressive disorder and other GS-related diseases: 《Acta Pharmacologica Sinica》2025年第4期880-891,共12页Jae Soon Kang Hwajin Kim Ji Hyeong Baek Miyoung Song Hyeongchan Park Wonjune Jeong Hye Jin Chung Dae Young Yoo Dong Kun Lee Sang Won Park Hyun Joon Kim; supported by the National Research Foundation(NRF)(Grant numbers NRF-2021R1A5A802949012 and 2022R1A2C100529611);the Commercializations Promotion Agency for R&D Outcomes(COMPA)(Grant number 1711173796)funded by the Ministry of Science and ICT(MSIT)of the Korean government.; Glutamine synthetase(GS)plays a crucial role in the homeostasis of the glutamate–glutamine cycle in the brain.Hypoactive GS causes depressive behaviors.Under chronic stress,GS has no change in expression,but its acti...; 关键词：depression glutamine synthetase tyrosine nitration tyrosine-containing dipeptide EPILEPSY HYPERAMMONEMIA

Bile duct ligation impairs visual acuity in rats by ammonia-and bilirubin-induced retinal degeneration: 《Acta Pharmacologica Sinica》2025年第2期380-392,共13页Yi-ting Yang Ming-rui Ji Zi-jin Lin Ping Li Run-ze Wu Xiao-dong Liu Li Liu; supported by the National Natural Science Foundation of China(No.82073922);the“Double First-Class”University Project(No.CPU2022QZ21).; Patients with hepatic failure are often accompanied by hepatic retinopathy,but the cellular and molecular mechanisms underlying the hepatic retinopathy remain unclear.In this study,we investigated how liver failure le...; 关键词：hepatic retinopathy bile duct ligation visual acuity retinal degeneration HYPERAMMONEMIA HYPERBILIRUBINEMIA

Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第6期485-498,共14页Xiaocheng LI Yaqing XIAO Pengfei LI Yayun ZHU Yonghong GUO Huijie BIAN Zheng LI; supported by the National Natural Science Foundation of China(No.82370592);the Discipline Construction Project of the Health System in Pudong New Area(No.PWZbr2022-15);the Pudong New Area Special Fund for Livelihood Research Project of Science and Technology Development Fund(No.PKJ2021-Y12),China.; End-stage liver diseases,such as cirrhosis and liver cancer caused by hepatitis B,are often combined with hepatic encephalopathy(HE);ammonia poisoning is posited as one of its main pathogenesis mechanisms.Ammonia is c...; 关键词：Hepatic encephalopathy HYPERAMMONEMIA AUTOPHAGY ST3β-galactosideα2 3-sialyltransferase 6(ST3GAL6) Heat shock proteinβ8(HSPB8)

5-Fluorouracil-Induced Hyperammonemia Encephalopathy in a Patient with Gastric Cancer: 《Journal of Cancer Therapy》2023年第2期102-106,共5页Toky Rakotoarivo Vonjy Andrianarison Ny Ony Andrianandrasana Malala Razakanaivo Florine Rafaramino; Chemotherapy with 5-fluorouracil (5 FU) has been widely used to treat advanced gastric cancer. Knowing the side effects is therefore important in order to better prevent them. Fluoropyrimidine-induced hyperammonemic e...; 关键词：ENCEPHALOPATHY Gastric Cancer HYPERAMMONEMIA 5-Fluororuracil

Unexplained hyperammonemia and encephalopathy in the emergency department:Abernethy malformation in elderly patients: 《World Journal of Emergency Medicine》2023年第1期69-71,共3页Yan-ying Gao Qing Tang Yan-cun Liu Xiao-he Liu Bao-xin Qian Yan-fen Chai Li-jun Wang; funded by the Tianjin Health Technology Project(20188);Peking Union Medical Foundation-Ruiyi Emergency Medical Research Fund(R2020010)。; Congenital extrahepatic portosystemic shunt(CEPS),also known as Abernethy malformation,is a rare disorder characterized by the partial or complete diversion of portal blood into systemic veins.CEPS is classified into ...; 关键词：MALFORMATION SHUNT PATIENTS

Treatment of portosystemic shunt-borne hepatic encephalopathy in a 97-year-old woman using balloon-occluded retrograde transvenous obliteration:A case report被引量：1: 《World Journal of Clinical Cases》2023年第4期945-951,共7页Akihiro Nishi Tsuneaki Kenzaka Misa Sogi Shuichiro Nakaminato Takahiro Suzuki; BACKGROUND Hyperammonemia and hepatic encephalopathy are common in patients with portosystemic shunts.Surgical shunt occlusion has been standard treatment,although recently the less invasive balloon-occluded retrograd...; 关键词：Hepatic encephalopathy HYPERAMMONEMIA Portosystemic shunt Balloon-occluded retrograde transvenous obliteration ELDERLY Case report

Mitochondrial hepatopathy: Anticipated difficulties in management of fatty acid oxidation defects and urea cycle defects被引量：2: 《World Journal of Hepatology》2022年第1期180-194,共15页Aathira Ravindranath Moinak Sen Sarma; Fatty acid oxidation defects(FAOD)and urea cycle defects(UCD)are among the most common metabolic liver diseases.Management of these disorders is dotted with challenges as the strategies differ based on the type and se...; 关键词：Mitochondrial hepatopathy Metabolic liver disease Liver transplantation HYPERAMMONEMIA HYPOGLYCEMIA CARNITINE

Relationship between the incidence of non-hepatic hyperammonemia and the prognosis of patients in the intensive care unit: 《World Journal of Gastroenterology》2020年第45期7222-7231,共10页Zhi-Peng Yao Yue Li Yang Liu Hong-Liang Wang; Supported by Scientific research project of Heilongjiang Health and Family Planning Commission,No.2019045.; BACKGROUND Ammonia is a normal constituent of body fluids and is found mainly through the formation of urea in the liver.Blood levels of ammonia must remain low as even slightly elevated concentrations(hyperammonemia)...; 关键词：Non-hepatic hyperammonemia Intestinal absorption Blood ammonia level Metabolism of amino acid Severe patients Intensive care unit

Analysis of treatment regimen in a pregnant patient with ornithine transcarbamylase deficiency: 《Journal of Chinese Pharmaceutical Sciences》2020年第9期666-670,共5页Lixia Li Yingxiu Liu Junming Du; Clinical Trial of Xinhua Hospital(Grant No.15LC11)。; As a common urea-cycle disorder, ornithine transcarbamylase deficiency(OTCD) disables the conversion of ammonia into non-toxic urea, and its subsequent excretion results in hyperammonemia. We reported a 28-year-old wo...; 关键词：Ornithine transcarbamylase deficiency PREGNANCY HYPERAMMONEMIA Sodium benzoate

Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis被引量：10: 《World Journal of Hepatology》2019年第6期489-512,共24页Daniela Campion Ilaria Giovo Paola Ponzo Giorgio M Saracco Federico Balzola Carlo Alessandria; Hepatic encephalopathy(HE)is a common and serious neuropsychiatric complication of cirrhosis,acute liver failure,and porto-systemic shunting.HE largely contributes to the morbidity of patients with liver disease,sever...; 关键词：CIRRHOSIS Hepatic encephalopathy DIET therapy GUT MICROBIOTA Leaky GUT HYPERAMMONEMIA Prebiotics Probiotics Gluten-casein free DIET GUT MICROBIOTA transplantation

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