AUTOPHAGY

作品数：1558被引量：7192H指数：34
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相关领域：医药卫生生物学更多>>
相关作者：金娟龚建光梁世凯何强石继红更多>>
相关机构：浙江省人民医院苏州大学北京大学中国科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Neuronal autosis:the self-destructive side of autophagy involved in hypoxic-ischemic neuronal death
《Neural Regeneration Research》2025年第12期3517-3518,共2页Vanessa Ginet Pauline Depierre Julien Puyal 
supported by grants from the Swiss National Science Foundation(310030-182332 and 310030L-208141)(to JP)。
The challenge of protecting the brain resides in the unique characteristics of neurons,as they are postmitotic,long-lived,excitable,and polarized cells with long and fragile axons and dendrites.The complexity of the m...
关键词：DEATH HYPOXIC polarized 
Autophagy regulation and function in axon regeneration:new insights from Caenorhabditis elegans
《Neural Regeneration Research》2025年第12期3519-3520,共2页Su-Hyuk Ko Lizhen Chen 
Autophagy plays a crucial role in axon regeneration by maintaining cellular homeostasis and promoting the clearance of damaged organelles and proteins,which is essential for the growth and repair of axons.In response ...
关键词：HOMEOSTASIS DEBRIS INSIGHT 
Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system
《Neural Regeneration Research》2025年第11期3209-3210,共2页Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell 
supported by Grants from Spanish FEDER/Science and Innovation Ministry I+D+i-RETOS-PID2021-124801NB-100;Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas(CIBERN ED;an initiative of the ISCIII)[PI2016/01];the Fundocion Ramon Areces and Banco Santander to the CBMSO(to FW)。
Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and function.This cellular process is evolutionarily highly conserved to quality control of many pr...
关键词：HOMEOSTASIS SYSTEM hereafter 
Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets
《Neural Regeneration Research》2025年第10期2787-2806,共20页Qingcong Zheng Du Wang Rongjie Lin Weihong Xu 
supported by the Natural Science Foundation of Fujian Province,No.2021J02035(to WX).
Regulated cell death is a form of cell death that is actively controlled by biomolecules.Several studies have shown that regulated cell death plays a key role after spinal cord injury.Pyroptosis and ferroptosis are ne...
关键词：AUTOPHAGY cell death ferroptosis INFLAMMATION pathological mechanisms PYROPTOSIS regulated cell death regulatory pathways spinal cord injury therapeutic targets 
Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications被引量：1
《Neural Regeneration Research》2025年第10期2872-2886,共15页Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti 
supported by:Fondazione Telethon-Italy(No.GGP19128 to AP);Fondazione Cariplo-Italy(No.2021-1544 to RC);Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica(AriSLA)-Italy(No.MLOpathy to AP;Target-RAN to AP);Association Française contre les Myopathies-France(AFM Telethon No.23236 to AP);Kennedy’s Disease Association-USA(2018 grant to RC;2020 grant to MG);Ministero dell’Universitàe della Ricerca(MIUR)-Italy(PRIN-Progetti di ricerca di interesse nazionale(No.2017F2A2C5 to AP;No.2022EFLFL8 to AP;No.2020PBS5MJ to VC;No.2022KSJZF5 to VC);PRIN-Progetti di ricerca di interesse nazionale-bando 2022,PNRR finanziato dall’Unione europea-Next Generation EU,componente M4C2,investimento 1.1(No.P2022B5J32 to RC and No.P20225R4Y5 to VC);CN3:RNA-Codice Proposta:CN_00000041;Tematica Sviluppo di terapia genica e farmaci con tecnologia a RNA(Centro Nazionale di Ricerca-CN3 National Center for Gene Therapy and Drugs based on RNA Technology to AP);Progetto Dipartimenti di Eccellenza(to DiSFeB);Ministero della Salute,Agenzia Italiana del Farmaco(AIFA)-Italy(Co_ALS to AP);Universitàdegli Studi di Milano(piano di sviluppo della ricerca(PSR)UNIMI-linea B(to RC and BT).
Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins.HSPB8 is involved in various cellular mechanisms mainly related to prote...
关键词：AGGREGATION AUTOPHAGY cancer CHAPERONE chaperone-assisted selective autophagy cognitive impairment HSPB8 NEUROINFLAMMATION neuromuscular diseases therapy 
Autophagy-targeting modulation to promote peripheral nerve regeneration
《Neural Regeneration Research》2025年第7期1864-1882,共19页Yan Chen Hongxia Deng Nannan Zhang 
supported by the National Natural Science Foundation of China,Nos.82271411(to RG),51803072(to WLiu);grants from the Department of Finance of Jilin Province,Nos.2022SCZ25(to RG),2022SCZ10(to WLiu),2021SCZ07(to RG);Jilin Provincial Science and Technology Program,No.YDZJ202201ZYTS038(to WLiu);The Youth Support Programmed Project of China-Japan Union Hospital of Jilin University,No.2022qnpy11(to WLuo);The Project of China-Japan Union Hospital of Jilin University,No.XHQMX20233(to RG)。
Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.Past studies have focused on factors that stimulat...
关键词：AUTOPHAGY autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy METFORMIN MYELINATION peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration 
EWSR1-PSMC5 fusion gene variously activating autophagy in drug resistance of osteosarcoma:A novel gene fusion model report and mechanism research
《Genes & Diseases》2025年第3期7-10,共4页Qing Pan Wenbo Yang Fuhua Huang Wei Wu Zengwu Shao Zhicai Zhang 
supported by the National Natural Science Foundation of China(No.82072979).
Sarcoma is a kind of mesenchymal malignant tumor and often has poor chemotherapy response.There are many reasons for the insensitivity of sarcomas to chemotherapy,among which genetic changes are important.As a common ...
关键词：AUTOPHAGY mesenchymal malignant tumor fusion mode drug resistance ewsr psmc fusion gene gene alterationgene fusion OSTEOSARCOMA genetic changes 
Role of ubiquitin-specific proteases in programmed cell death of breast cancer cells
《Genes & Diseases》2025年第3期319-328,共10页Wen Yan Shasha Xiang Jianbo Feng Xuyu Zu 
supported by grants from University of South China Innovation Foundation For Postgraduate(233YXC001);Postgraduate Scientific Research Innovation Project of Hunan Province(CX20230955);the National Natural Science Foundation of China(No.82103171,Jianbo Feng);the Clinical Medical Research“4310”Program of the University of South China(20224310NHYCG07).
Breast cancer (BC) is the most common malignant tumor and the leading cause ofcancer-related deaths among women worldwide. Great progress has been recently achieved incontrolling breast cancer;however, mortality from ...
关键词：ANOIKIS Apoptosis AUTOPHAGY Breast cancer Ferroptosis PYROPTOSIS Ubiquitin-specific proteases 
Mycobacterial antigen Ag85B restrains Hodgkin lymphoma tumor growth by inhibiting autophagy
《Oncology Research》2025年第5期1173-1187,共15页YONGFENG CHENG YIPING SHEN YUNFEI ZHANG HAILIQIGULI NURIDING XUEMEI WANG CHUNYAN FAN GULIBAHA MAIMAITI YU LIU YINGBIN YUE DANLU LI MEI YAN 
supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region of China(grant number 2022D01C739);the National Natural Science Foundation of China(grant numbers 82160031,82071276);the Key Research and Development Program of Xinjiang Uyghur Autonomous Region of China(grant number 2024B03038-1).
Background:The growth of the B-cell lymphoma subtype,Hodgkin lymphoma(HL),is associated with increased autophagy.A mycobacterial antigen,Ag85,has been reported to inhibit cell autophagy under a variety of conditions.W...
关键词：Hodgkin disease Mycobacterial antigen AUTOPHAGY Protein kinase B Mitogen-activated protein kinases 
Correction: Silencing of the long non-coding RNA LINC00265triggers autophagy and apoptosis in lung cancer by reducingprotein stability of SIN3A oncogene
《Oncology Research》2025年第5期1249-1250,共2页XIAOBI HUANG CHUNYUAN CHEN YONGYANG CHEN HONGLIAN ZHOU YONGHUA CHEN ZHONG HUANG YULIU XIE BAIYANG LIU YUDONG GUO ZHIXIONG YANG GUANGHUA CHEN WENMEI SU 
In the article“Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene”(Oncology Research.2024,Vol.32,No.7,pp.1185–1195.doi:10....
关键词：lung cancer long non coding RNA reducing protein stability sin oncogene oncology AUTOPHAGY protein stability APOPTOSIS accuracy integrity SILENCING 
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