Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system  

作　　者：Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell 

机构地区：[1]Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM),Nicolas Cabrera 1,Universidad Autónoma de Madrid,Madrid,Spain [2]Fisiología Animal,Departamento de Biología,Facultad de Ciencias,Universidad Autónoma de Madrid,Madrid,Spain [3]Department of Clinical Neuroscience,CMM Karolinska Universitetssjukhuset Solna,Stockholm,Sweden [4]Departamento de Bioquímica y Biología Molecular,Universidad Complutense de Madrid,Madrid,Spain [5]Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED),Madrid,Spain

出　　处：《Neural Regeneration Research》2025年第11期3209-3210,共2页中国神经再生研究（英文版）

基　　金：supported by Grants from Spanish FEDER/Science and Innovation Ministry I+D+i-RETOS-PID2021-124801NB-100;Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas(CIBERN ED;an initiative of the ISCIII)[PI2016/01];the Fundocion Ramon Areces and Banco Santander to the CBMSO(to FW)。

摘　　要：Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and function.This cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino acids.This process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein markers.Some of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关 键 词：HOMEOSTASIS SYSTEM hereafter 

分 类 号：R741[医药卫生—神经病学与精神病学]