MYELINATION

作品数：75被引量：230H指数：7
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相关领域：医药卫生生物学更多>>
相关作者：翁勤洁更多>>
相关机构：浙江大学南京大学更多>>
相关期刊：《Life Research》《Journal of Integrative Medicine》《神经药理学报》《Chinese Journal of Integrative Medicine》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
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Intersection of mitochondrial dysfunction and myelination:An overlooked aspect in neurodevelopmental disorders
《Neural Regeneration Research》2026年第2期659-660,共2页Ariel Nir Sade Gal Wiener Boaz Barak 
Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th...
关键词：neurodevelopmental disorders ndds rokach white matter developing brain MYELINATION neurodevelopmental processes mitochondrial dysfunction white matter wm known developing braina 
FIREproof:Intricacies of microglial biology
《Neural Regeneration Research》2026年第2期663-664,共2页Wei Cao 
funded by NIH grants HL154720-03S1,AG057587,AG074283,DK122708-03S1,BrightFocus ADR A20183775,and Brown Foundation 2020 Healthy Aging Initiative(to WC).
Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases....
关键词：neurological diseases facilitating neurogenesis debris removal central nervous systemincluding NEUROGENESIS MYELINATION synapse pruning brain 
EZH2-dependent myelination following sciatic nerve injury
《Neural Regeneration Research》2025年第8期2382-2394,共13页Hui Zhu Li Mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue 
financially supported by the National Natural Science Foundation of China,Nos.82172104(to CX),81873767(to HZ);a grant from Jiangsu Provincial Research Hospital,Nos.YJXYY202204(to HZ),YJXYY202204-ZD04(to HZ);a grant from Jiangsu Provincial Key Medical Center;Jiangsu Provincial Medical Innovation Center,No.CXZX202212;Jiangsu Provincial Medical Key Discipline,No.ZDXK202240;the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);Technology Project of Nantong,No.MS22022008(to HZ);Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.SJCX21_1457(to WW)。
Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve injury.Notably,the gene regulatory network of regenerated myelin differs from that ...
关键词：DEMYELINATION EZH2 MYELINATION peripheral nerve injury PRC2 REMYELINATION Schwann cells sciatic nerve crush sciatic nerve transection 
Autophagy-targeting modulation to promote peripheral nerve regeneration
《Neural Regeneration Research》2025年第7期1864-1882,共19页Yan Chen Hongxia Deng Nannan Zhang 
supported by the National Natural Science Foundation of China,Nos.82271411(to RG),51803072(to WLiu);grants from the Department of Finance of Jilin Province,Nos.2022SCZ25(to RG),2022SCZ10(to WLiu),2021SCZ07(to RG);Jilin Provincial Science and Technology Program,No.YDZJ202201ZYTS038(to WLiu);The Youth Support Programmed Project of China-Japan Union Hospital of Jilin University,No.2022qnpy11(to WLuo);The Project of China-Japan Union Hospital of Jilin University,No.XHQMX20233(to RG)。
Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.Past studies have focused on factors that stimulat...
关键词：AUTOPHAGY autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy METFORMIN MYELINATION peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration 
Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage被引量：2
《Neural Regeneration Research》2025年第4期1015-1030,共16页Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo Wan Tao Wang 
supported by the National Natural Science Foundation of China,No.82072110;Suzhou Municipal Science and Technology Bureau,No.SKJY2021046;Shanghai Key Lab of Forensic Medicine&Key Lab of Forensic Science,Ministry of Justice,China(Academy of Forensic Science),No.KF202201;a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)(all to TW).
Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and myelination.Cholesterol ...
关键词：cell death cholesterol metabolism intracerebral hemorrhage MYELINATION therapeutic target 
Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age‑dependent Manner
《Neuroscience Bulletin》2025年第3期374-390,共17页Hong Chen Gang Yang De‑En Xu Yu‑tong Du Chao Zhu Hua Hu Li Luo Lei Feng Wenhui Huang Yan‑Yun Sun Quan‑Hong Ma 
supported by the STI2030-Major Projects(2021ZD0204001);the National Natural Science Foundation of China(92049120,81870897,81271424,81671111,and 62475179);the Sino German Cooperation and Exchange Project(M-0679);the Guangdong Key Project in the Development of New Tools for the Diagnosis and Treatment of Autism(2018B030335001);the Natural Science Foundation of Jiangsu Province(BK20181436);the Priority Academic Program Development of Jiangsu Higher Education Institutions,the Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases(BM2013003);Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,Suzhou Science and Technology Plan Medical and Health Care Science and Technology Innovation Applied Basic Research(SKY2022161);the Research Project of Neurological Diseases in the Second Affiliated Hospital of Soochow University Research Center(ND2023A01);Boxi clinical research project of The First Affiliated Hospital of Soochow University(BXQN202204);Suzhou Science&Technology Projects for People's Livelihood(SKY2021065);Wuxi Municipal Health Commission(M202204).
Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the...
关键词：AUTOPHAGY Oligodendrocyte precursor cells OLIGODENDROCYTES MYELINATION Myelin proteins Turnover Degradation 
Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system
《Signal Transduction and Targeted Therapy》2024年第10期4683-4699,共17页Yanli Chang Jiangli Zhu Xiaopeng Li Yi Deng Birou Lai Yidan Ma Jia Tong Huicong Liu Juanjuan Li Chenyu Yang Qiao Chen Chengbiao Lu Yinming Liang Shiqian Qi Xiaoning Wang Eryan Kong 
National Natural Science Foundation of China(Grant No.32100776 to Y.L.C.,and No.32371309 to E.Y.K.);The genetic modification of cell lines and mouse were supported by 111 program(D20036).
The downregulation of Cadm4 (Cell adhesion molecular 4) is a prominent feature in demyelination diseases, yet, the underlying molecular mechanism remains elusive. Here, we reveal that Cadm4 undergoes specific palmitoy...
关键词：MYELIN SYSTEM TOGETHER 
Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model
《Neuroscience Bulletin》2024年第8期1037-1052,共16页Chenrui Yin Kefei Luo Xinyue Zhu Ronghang Zheng Yu Wang Guangdan Yu Xiaorui Wang Fei She Xiaoying Chen Tao Li Jingfei Chen Baduojie Bian Yixun Su Jianqin Niu Yuxin Wang 
supported by grants from the National Nature Science Foundation of China(32271034,32070964,82301703,32300791,and 81901378);Science and Technology Innovation Enhancement Project of Army Medical University(2022XQN40);National Key Research and Development Program of China(2021ZD0201703);Chongqing Natural Science Fund for Distinguished Young Scholars(CSTB2023NSCQ-JQX0030);Undergraduate Research Cultivation Project of Army Medical University(2020XBK16);Guangdong Basic and Applied Basic Research Foundation(2021A1515110268 and 2023A1515010651);Shenzhen Fundamental Research Program(RCBS20210706092411028 and JCYJ20210324121214039).
Posttraumatic stress disorder(PTSD)is a complex mental disorder notable for traumatic experience memory.Although current first-line treatments are linked with clinically important symptom reduction,a large proportion ...
关键词：PTSD Fear memory MYELINATION Oligodendroglial differentiation FLUOXETINE Wnt signaling 
Runx2 regulates peripheral nerve regeneration to promote Schwann cell migration and re-myelination被引量：5
《Neural Regeneration Research》2024年第7期1575-1583,共9页Rong Hu Xinpeng Dun Lolita Singh Matthew C.Banton 
supported by the National Natural Science Foundation of China,No.82104795 (to RH)。
Runx2 is a major regulator of osteoblast differentiation and function;however,the role of Runx2 in peripheral nerve repair is unclea r.Here,we analyzed Runx2expression following injury and found that it was specifical...
关键词：macrophage clearance MIGRATION peripheral nerve injury regeneration re-myelination RUNX2 Schwann cells 
Does astrocytic L-lactate enhance cognition through myelination?
《Neural Regeneration Research》2024年第6期1167-1168,共2页Mastura Akter Ying Li 
funded by the General Research Fund(GRF)of the Research Grants Council of Hong Kong,China(11103721,11102820,and 11100018);the National Natural Science Foundation of China(NSFC)and RGC Joint Research Scheme(3171101014,N_CityU114/17);the Innovation and Technology Fund Hong Kong,China(CityU 9445909)(all to YL);supported by a grant from City University of Hong Kong Neuroscience Research Infrastructure(9610211);a grant from Center for Biosystems;Neuroscience,and Nanotechnology(9360148)(both to YL)。
Introduction:Astrocytes,the predominant glial cell in the brain,play a vital role in a plethora of central nervous system functions.They are the major storage site of glycogen in the central nervous system.They produc...
关键词：MYELIN specialized predominant 
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