FLUOXETINE

作品数：80被引量：233H指数：8
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相关领域：医药卫生更多>>
相关作者：周宏灏刘昭前顾建新潘冰峰冯青更多>>
相关机构：南京中医药大学湖南医科大学重庆医科大学中国科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金上海市自然科学基金更多>>
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In vitro effects of antidepressants on human sperm function
《Asian Journal of Andrology》2025年第1期30-36,共7页Rita António Santos Ana Paula Sousa Teresa Almeida-Santos Joao Ramalho-Santos Renata Santos Tavares 
Depression currently affects about 280 million people worldwide and its prevalence has been increasing dramatically,especially among the young and people of reproductive age,which consequently leads to an increase in ...
关键词：FLUOXETINE human sperm male fertility SERTRALINE sperm function SSRIS 
Recent advancements in digital and traditional treatment strategies for major depressive disorder using medicinal herbs
《Digital Chinese Medicine》2024年第4期365-387,共23页Manasi Khadanga Nihar Ranjan Kar Nityananda Sahoo Bichitrananda Tripathy 
Integrating digital health technologies,including mobile applications and digital biomarkers,with traditional medicinal plants and phytochemicals may enhance the effectiveness of standard antidepressants.Mechanisms th...
关键词：FLUOXETINE Major depressive disorder(MDD) PHYTOMEDICINE Neurological disorders DEPRESSION Digital health 
Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model
《Neuroscience Bulletin》2024年第8期1037-1052,共16页Chenrui Yin Kefei Luo Xinyue Zhu Ronghang Zheng Yu Wang Guangdan Yu Xiaorui Wang Fei She Xiaoying Chen Tao Li Jingfei Chen Baduojie Bian Yixun Su Jianqin Niu Yuxin Wang 
supported by grants from the National Nature Science Foundation of China(32271034,32070964,82301703,32300791,and 81901378);Science and Technology Innovation Enhancement Project of Army Medical University(2022XQN40);National Key Research and Development Program of China(2021ZD0201703);Chongqing Natural Science Fund for Distinguished Young Scholars(CSTB2023NSCQ-JQX0030);Undergraduate Research Cultivation Project of Army Medical University(2020XBK16);Guangdong Basic and Applied Basic Research Foundation(2021A1515110268 and 2023A1515010651);Shenzhen Fundamental Research Program(RCBS20210706092411028 and JCYJ20210324121214039).
Posttraumatic stress disorder(PTSD)is a complex mental disorder notable for traumatic experience memory.Although current first-line treatments are linked with clinically important symptom reduction,a large proportion ...
关键词：PTSD Fear memory MYELINATION Oligodendroglial differentiation FLUOXETINE Wnt signaling 
Theoretical insights of the pharmaceutical compound fluoxetine in water:Role in direct photolysis and indirect photolysis by free radicals
《Journal of Environmental Sciences》2024年第8期269-278,共10页Ying Lu Se Wang Yifan Shen 
supported by the National Natural Science Foundation of China(No.41601519)。
The frequent detection of pharmaceutical compounds in the environment has led to a growing awareness,which may pose a major threat to the aquatic environment.In this study,photodegradation(direct and indirect photolys...
关键词：FLUOXETINE Photochemical mechanism Direct photolysis Free radical reaction DFT 
Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder被引量：2
《National Science Review》2023年第11期29-39,共11页Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui Jin Yuxian Zhang He Li Zhi Yang Guan Ning Lin Dan JStein Zhi-Qi Xiong Zhen Wang 
supported by the Innovation of Science and Technology 2030-Major Project‘platform of nonhuman primate models’(2021ZD0200900 to Z.-Q.X.and R.W.Z.);the grants from Lingang Lab(LG202106-03 to Z.W.and R.W.Z.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32060000 to Z.-Q.X.);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05 to Z.-Q.X.);the National Natural Science Foundation of China(82230045 to Z.W.and 32000709 to R.W.Z.);the key project of Shanghai Mental HealthCenter at the hospital level(2019-zd02 to R.W.Z.).
Obsessive-compulsive disorder(OCD)is a chronic and debilitating psychiatric disorder that affects∼2%–3%of the population globally.Studying spontaneous OCD-like behaviors in non-human primates may improve our underst...
关键词：obsessive-compulsive disorder(OCD) primate ritualistic behavior model OCD risk genes caudate nucleus FLUOXETINE 
Fluoxetine Ameliorates the Aggravation of UC Symptoms in C57BL/6 Mice Induced by CUMS
《Current Medical Science》2023年第5期1033-1042,共10页Teng ZHAO Yu-xin ZHOU Rong-jie WANG Ping WAN Ying LI Liang-liang ZHOU Zhen-hua CHEN 
supported by grants from the National Natural Science Foundation Youth Project of China(No.81703716);Jiangxi Science Foundation for Distinguished Young Scholars(No.20224ACB216019);the Natural Science Foundation of Jiangxi Province(No.20202BABL206151 and No.20202BABL216026);Youth Talents Project of Jiangxi Science and Technology Normal University(No.2017QNBJRC006);Doctoral Startup Fund of Jiangxi Science and Technology Normal University(No.2019BSQD015);Department Education Science and Technology Research Project of Jiangxi(No.GJJ201134);the Open Project of Jiangxi Provincial Key Laboratory of Drug Design and Evaluation(No.JKD-KF-2104);the National Undergraduate Training Program for Innovation of China(No.202211318024).
Objective Patients with chronic ulcerative colitis(UC)often have mental symptoms such as depression and anxiety,and stress can lead to gastrointestinal diseases.However,the correlation between mental stress and UC is ...
关键词：ulcerative colitis chronic unpredictable mild stress FLUOXETINE dextran sulfate sodium BEHAVIOR 
Delineation of biomarkers and molecular pathways of residual effects of fluoxetine treatment in juvenile rhesus monkeys by proteomic profiling被引量：1
《Zoological Research》2023年第1期30-42,共13页Yu Yan Dong Ik Park Anja Horn Mari Golub Christoph W.Turck 
supported by the Max Planck Society to C.W.T.and National Institutes of Health USDHHS(R01-HD065826to M.G.,OD011107 to Harris Lewin)。
Fluoxetine(Prozac^(TM))is the only antidepressant approved by the US Food and Drug Administration(FDA)for the treatment of major depressive disorder(MDD)in children.Despite its considerable efficacy as a selective ser...
关键词：Major depressive disorder FLUOXETINE Rhesus monkeys PROTEOMICS GABAergic synapse 
The effect of fluoxetine combined with repetitive transcranial magnetic stimulation on the psychological emotions and cognitive and neurological functions of acute post-stroke depression patients
《中华物理医学与康复杂志》2022年第10期887-887,共1页
Objective This research was designed to probe into the effects of fluoxetine combined with repetitive transcranial magnetic stimulation (rTMS) on the psychological emotions and the cognitive and neurological functions...
关键词：STIMULATION PATIENTS NEUROLOGICAL 
Cinnamaldehyde prevents intergenerational effect of paternal depression in mice via regulating GR/miR-190b/BDNF pathway被引量：2
《Acta Pharmacologica Sinica》2022年第8期1955-1969,共15页Zhi-ying Gao Tian-yu Chen Ting-ting Yu Li-ping Zhang Si-jie Zhao Xiao-yang Gu Ying Pan Ling-dong Kong 
supported by the Fundamental Research Funds for the Central Universities.
Paternal stress exposure-induced high corticosterone(CORT)levels may contribute to depression in offspring.Clinical studies disclose the association of depressive symptoms in fathers with their adolescent offspring.Ho...
关键词：DEPRESSION intergenerational inheritance CINNAMALDEHYDE FLUOXETINE corticosterone GR 
New monoamine antidepressant,hypidone hydrochloride(YL-0919),enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism被引量：3
《Acta Pharmacologica Sinica》2022年第7期1699-1709,共11页Yong-mei Zhang Lu-yu Ye Tian-yu Li Fan Guo Fei Guo Yang Li Yun-feng Li 
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040220);the National Natural Science Foundation of China(31671049,81773708,81072624,and 81173036);the National Key New Drug Creation Program of China(No.2017ZX09309012,2018ZX09739008,and 2018ZX09711002-002-012).
Hypidone hydrochloride(YL-0919)is a novel antidepressant in clinical phase II trial.Previous studies show that YL-0919 is a selective 5-HT(serotonin)reuptake inhibitor,5-HT1A receptor partial agonist,and 5-HT6 recepto...
关键词：YL-0919 medial prefrontal cortex GABAergic neurons 5-HT1A receptor GAD67-GFP transgenic mice DISINHIBITION FLUOXETINE electrophysiological recording 
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