DISINHIBITION

作品数：6被引量：13H指数：2
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相关领域：生物学医药卫生更多>>
相关作者：李雪莹更多>>
相关机构：天津医科大学南开大学更多>>
相关期刊：《World Journal of Clinical Cases》《Progress in Natural Science:Materials International》《Acta Pharmacologica Sinica》《Psychology Research》更多>>
相关基金：国家自然科学基金更多>>
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New monoamine antidepressant,hypidone hydrochloride(YL-0919),enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism被引量：3
《Acta Pharmacologica Sinica》2022年第7期1699-1709,共11页Yong-mei Zhang Lu-yu Ye Tian-yu Li Fan Guo Fei Guo Yang Li Yun-feng Li 
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040220);the National Natural Science Foundation of China(31671049,81773708,81072624,and 81173036);the National Key New Drug Creation Program of China(No.2017ZX09309012,2018ZX09739008,and 2018ZX09711002-002-012).
Hypidone hydrochloride(YL-0919)is a novel antidepressant in clinical phase II trial.Previous studies show that YL-0919 is a selective 5-HT(serotonin)reuptake inhibitor,5-HT1A receptor partial agonist,and 5-HT6 recepto...
关键词：YL-0919 medial prefrontal cortex GABAergic neurons 5-HT1A receptor GAD67-GFP transgenic mice DISINHIBITION FLUOXETINE electrophysiological recording 
BDNF rescues prefrontal dysfunction elicited by pyramidal neuron-specific DTNBP1 deletion in vivo被引量：2
《Journal of Molecular Cell Biology》2017年第2期117-131,共15页Wen Zhang Kathryn M. Daly Bo Liang Lifeng Zhang Xuan Li Yun Li Da-Ting Lin 
Dystrobrevin-binding protein 1 （Dtnbp1） is one of the earliest identified schizophrenia susceptibility genes. Reduced expression of DTNBP1 is commonly found in brain areas of schizophrenic patients. Dtnbp1-nuU mutan...
关键词：SCHIZOPHRENIA GABAERGIC DISINHIBITION PFC BDNF Dtnbp1 
Vampiristic behaviors in a patient with traumatic brain injury induced disinhibition
《World Journal of Clinical Cases》2016年第6期138-141,共4页William M Hervey Glenn Catalano Maria C Catalano 
Vampiristic behaviors are rarely seen clinically and less than 100 cases have been reported in the world literature to date. A distinction is usually made as to whether the patient drinks their own blood or the blood ...
关键词：Vamipirism DISINHIBITION TRAUMATIC brain INJURY Hematophagia BLOOD 
Disinhibition as the Foundation for Reinforcement in Conditioned Acquisition of Active Behaviors
《Psychology Research》2013年第2期53-68,共16页Galina I. Shul'gina 
关键词：行为方式 加固 基金会 神经元活动 收购 空调 中脑网状结构 时间分布规律 
Somatosensory disinhibition in patients with paroxysmal kinesigenic dyskinesia被引量：2
《Chinese Medical Journal》2012年第5期838-842,共5页WEI Hua SUN Ying CHEN Hai WANG De-quan LI Li-ping DING Yan LIU Ai-hua LU Chang-feng WANG Yu-ping 
Background Paroxysmal kinesigenic dyskinesia （PKD） is characterized by recurrent brief episodes of chorea and dystonia induced by sudden movement. Whether the central nervous system is hyper- or hypoexcitable in PKD...
关键词：paroxysmal kinesigenic dyskinesia somatosensory evoked potentials recovery cycle paired stimulation 
Effects of disinhibition on spatiotemporal pattern of neuronal first recruitment in neuronal networks被引量：6
《Progress in Natural Science:Materials International》2009年第5期615-621,共7页Liangbin Pana,b,c,1, Xindong Songa,b,c,1, Guangxin Xiang a,b,c, Jing Zhua,b,c, Jing Cheng a,b,c,d,a Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China b Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China c National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing 102206, China d State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China 
supported by the National High-Tech Research and Development Program of China (Grant No.2006AA020701)
The propagation of neuronal activities is a key feature to understanding information processing in networks. The analysis based on first-spikes of bursts in turn plays an important role in the research of neuronal act...
关键词：Neuronal recruitment Spatiotemporal pattern DISINHIBITION Network Multi-electrode array 
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