Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder  

作　　者：Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui Jin Yuxian Zhang He Li Zhi Yang Guan Ning Lin Dan JStein Zhi-Qi Xiong Zhen Wang 

机构地区：[1]Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China [2]Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China [3]Lingang Laboratory,Shanghai 200031,China [4]Shanghai Center for Brain Science and Brain-Inspired Technology,Shanghai 201602,China [5]Translational Neuropsychiatry Unit(TNU),Department of Clinical Medicine,Aarhus University,Aarhus 8200,Denmark [6]Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China

出　　处：《National Science Review》2023年第11期29-39,共11页国家科学评论（英文版）

基　　金：supported by the Innovation of Science and Technology 2030-Major Project‘platform of nonhuman primate models’(2021ZD0200900 to Z.-Q.X.and R.W.Z.);the grants from Lingang Lab(LG202106-03 to Z.W.and R.W.Z.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32060000 to Z.-Q.X.);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05 to Z.-Q.X.);the National Natural Science Foundation of China(82230045 to Z.W.and 32000709 to R.W.Z.);the key project of Shanghai Mental HealthCenter at the hospital level(2019-zd02 to R.W.Z.).

摘　　要：Obsessive-compulsive disorder(OCD)is a chronic and debilitating psychiatric disorder that affects∼2%–3%of the population globally.Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder.In large rhesus monkey colonies,we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs)in individual-specific sequences that were repetitive,time-consuming and stable over prolonged periods.Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans.Brain imaging showed that monkeys with SMBs had larger gray matter(GM)volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum.The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs.Notably,exposure to a stressor(human presence)significantly increased SMBs.In addition,fluoxetine,a serotonergic medication commonly used for OCD,decreased SMBs in these monkeys.These findings provide a novel foundation for developing better understanding and treatment of OCD.

关 键 词：obsessive-compulsive disorder(OCD) primate ritualistic behavior model OCD risk genes caudate nucleus FLUOXETINE 

分 类 号：R749.7[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]