PROTEOMICS

作品数：763被引量：1780H指数：18
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相关机构：军事医学科学院中国科学院北京大学复旦大学更多>>
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AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis
《Neural Regeneration Research》2025年第8期2408-2419,共12页Ruiqi Qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng Han Bo Lei 
supported by the National Natural Science Foundation of China,Nos.82071008(to BL)and 82004001(to XJ);Medical Science and Technology Program of Health Commission of Henan Province,No.LHGJ20210072(to RQ);Science and Technology Department of Henan Province,No.212102310307(to XJ)。
Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell death.However,there is no effective treatment for retinitis pigmentosa caused by PDE6B mutation.Adeno-asso...
关键词：APOPTOSIS AAV2-PDE6B ERK1/2 gene therapy PHOTOTRANSDUCTION PROTEOMICS rd10 retinitis pigmentosa 
Artificial intelligence and the impact of multiomics on the reporting of case reports
《World Journal of Clinical Cases》2025年第15期1-6,共6页Aishwarya Boini Vincent Grasso Heba Taher Andrew A Gumbs 
The integration of artificial intelligence(AI)and multiomics has transformed clinical and life sciences,enabling precision medicine and redefining disease understanding.Scientific publications grew significantly from ...
关键词：Artificial intelligence Multiomics Precision medicine GENOMICS PROTEOMICS Metabolomics Radiomics Pathomics Surgomics Predictive modeling 
Characterization of the colostrum proteome of primiparous Holstein cows and its association with colostrum immunoglobulin G concentrations
《Journal of Animal Science and Biotechnology》2025年第2期931-947,共17页Ezequias Castillo-Lopez Patrick Biber Arife Sener-Aydemir Karin Hummel Ebrahim Razzazi-Fazeli Nicole Reisinger Qendrim Zebeli Susanne Kreuzer-Redmer Thomas Hartinger 
supported by Austrian Federal Ministry for Digital and Economic Affairs;the National Foundation for Research,Technology and Development;supported using resources of the Vet Core Facility(Mass Spectrometry)of the University of Veterinary Medicine Vienna。
Background The objective was to characterize the colostrum proteome of primiparous Holstein cows in association with immunoglobulin G(IgG)content.Immediately after calving,colostrum samples were collected from 18 cows...
关键词：Bovine colostrum COW IMMUNOGLOBULINS Passive immunity PROTEOMICS 
TMT-based quantitative proteomics reveals the potential mechanism of the FufangMuji Granules in carbon tetrachloride-induced liver injury
《Traditional Medicine Research》2025年第4期21-30,共10页Lei Men Ya-Qi Shi Xin-Yue Wang Ke-Ke Li Zhong-Yu Li Chun-Bin Li Xiao-Jie Gong 
National Natural Science Foundation of China(82104532 and 82173913);Joint Program(Applied Basic Research Project)of Liaoning Provincial Science and Technology Program(2023JH2/101700074);High-level Talent Innovation Support Program of Dalian(2021RD10);Fundamental Research Funds for the Central Universities(2023-SWGC-0101)。
Background:Fufang Muji Granules is a traditional Chinese medicine of the Manchu ethnic group and is thought to treat hepatitis and liver injury by inhibiting the elevation of alpha-fetoprotein.Methods:In this investig...
关键词：PROTEOMICS Fufang Muji Granules liver injury traditional Chinese medicine 
Proteomic insights from extracellular vesicles into the molecular mechanisms of health effects induced by Per-and polyfluoroalkyl substances
《Journal of Environmental Sciences》2025年第4期395-411,共17页Yanping Li Yadan Luo Yang Liu Na Li Kai Huang Lingxiangyu Li Zhigang Li Chao Han Nali Zhu Yawei Wang Guibin Jiang 
supported by the Key Research and Development Plan of Zhejiang Province(No.2021C03176);Zhejiang Provincial Natural Science Foundation of China(No.LY23B070001);the Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province(No.20230009);the National Natural Science Foundation of China(No.22106032);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750000).
Per-and polyfluoroalkyl substances(PFASs)can induce a range of adverse health effects,with the precise molecularmechanisms remaining elusive.Extracellular vesicles(EVs)have demonstrated their potential to elucidate un...
关键词：Per-and polyfluoroalkyl substances Extracellular vesicles Health effects PROTEOMICS PROTEASOME 
Osteosarcopenia and geriatric hip fractures:Current concepts
《World Journal of Orthopedics》2025年第3期35-40,共6页Theodoros Tosounidis Lefteris Manouras Byron Chalidis 
According to World Health Organization,one in six people will be older than 60 by 2030.The rising life expectancy is anticipated to contribute to a subsequent increase of geriatric fractures worldwide.Osteosarcopenia,...
关键词：Osteosarcopenia Hip fracture Fragility fracture MORTALITY RNA-sequencing PROTEOMICS Muscle-bone crosstalk 
Navigating the landscape of plant proteomics
《Journal of Integrative Plant Biology》2025年第3期740-761,共22页Tian Sang Zhen Zhang Guting Liu Pengcheng Wang 
supported by the National Key Research and Development Program of China (2021YFA1300402 to P.W.);the National Natural Science Foundation of China (32471500 to P.W.)。
In plants, proteins are fundamental to virtually all biological processes, such as photosynthesis,signal transduction, metabolic regulation, and stress responses. Studying protein distribution,function, modifications,...
关键词：mass spectrometry plant biology post-translational modification(PTM) PROTEOMICS 
Caterpillar feeding drives patterns of induced defenses and herbivore resistance in wild Pinus tabuliformis
《Journal of Forestry Research》2025年第1期391-411,共21页Tianhua Sun Guona Zhou Yanan Zhao Suhong Gao Jie Liu Junxia Liu Baojia Gao 
supported by the Science and Technology Development Program of Hebei Agricultural University,the Research on Molecular Mechanisms of Population Differentiation and Adaptation of Forest Pests and Insects under Environmental Stress(grant No.:30771739);Forest Pests and Diseases(grant No.:1528003);the National Natural Science Foundation of China for the study of community regulatory mechanisms of insect pest pandemics in larch plantation forests(Grant No.:32371882).
The defense mechanisms induced in wild Chinese pine(Pinus tabuliformis)in response to herbivores are not well characterized,especially in the field.To address this knowledge gap,we established a biological model syste...
关键词：Pinus tabuliformis Dendrolimus tabulaeformis PROTEOMICS Induced Defensive responses 
Quantitative proteomic analysis of the brain reveals the potential antidepressant mechanism of Jiawei Danzhi Xiaoyao San(加味丹栀逍遥散) in a chronic unpredictable mild stress mouse model of depression
《Journal of Traditional Chinese Medicine》2025年第1期22-31,共10页LI Yajing WANG Baoying SHAO Wenxue LU Shuaifei SU Pan BAI Ming XU Erping LI Yucheng 
the National Natural Science Foundation of China:Study on the Biological Basis of Jiawei Danzhi Xiaoyaosan in Treatment of Depression based on Network Pharmacology and Proteomics(No.81973739);Natural Science Excellent Youth Fund of Henan Province:the Mechanism of Baicalin Regulates the GSK3B-Mediated Axoplasmic Transport in the Treatment of Depression(No.202300410249);Science and Technology Research Project of Henan Province:Study on the Antidepressant Mechanism of Jiawei Danzhi Xiaoyaosan based on the NOD-like Receptor Thermal Protein Domainassociated Protein and Tripartite Motif-containing Protein 31 Ubiquitination Pathway(No.222102310233);Study on the Mechanism of Jiawei Danzhi Xiaoyaosan in the Treatment of Depression by Regulating M1/M2 Polarization and Microglia Autophagy(No.232102310419)。
OBJECTIVE:To reveal the antidepressant mechanisms of Jiawei DanZhiXiaoYaoSan(加味丹栀逍遥散,JD)in chronic unpredictable mild stress(CUMS)-induced depression in mice.METHODS:Using the CUMS mouse model of depression,the...
关键词：DEPRESSION PROTEOMICS intermediate filaments mitogen-activated protein kinases Jiawei Danzhi Xiaoyaosan 
Single-cell omics: experimental workflow, data analyses and applications被引量：1
《Science China(Life Sciences)》2025年第1期5-102,共98页Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi 
supported by the National Natural Science Foundation of China(32130020,32025009,82030099,30700397,31970638,61572361,81973701,U23A20513,32222026,82373446);the National Key Research and Development Program of China(2021YFF1201200,2021YFF1200900,2022YFA1106000);the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01);the Fundamental Research Funds for the Central Universities(20002150110,22120230292);Beihang University&Capital Medical University Plan(BHME-201904);the Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority(XTCX201809);the Cooperative Research Fund of the Affiliated Wuhu Hospital of East China Normal University(40500-20104-222400);the Fundamental Research Funds for the Central Universities(226-2024-00001);the Shanghai Municipal Science and Technology Commission“Science and Technology Innovation Action Plan”technical standard project(21DZ2201700);the Shanghai Municipal Science and Technology Commission“Science and Technology Innovation Action Plan”natural science foundation project(23ZR1435800);the Shanghai Natural Science Foundation Program(17ZR1449400);the Shanghai Artificial Intelligence Technology Standard Project(19DZ2200900);the Open Research Fund of Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE,ECNU,Key Laboratory of MEA,Ministry of Education,ECNU.
Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features.Our exploration of how the genomes orchestrate the formation and maintenance of each cell,and co...
关键词：single-cell sequencing genome EPIGENOME PROTEOMICS metabolomics multimodal spatial transcriptomics CRISPR screening 
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