PROTEASOME

作品数：158被引量：433H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：邹晓民徐萍田蕊李卉王超更多>>
相关机构：北京大学苏州大学北京协和医学院吉林大学第二医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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NARROW AND ROLLED LEAF 9,a Novel Gene Encoding 20S Proteasome β1 Subunit that Regulates Leaf Morphology and Grain Size in Rice
《Rice science》2025年第2期143-146,I0004-I0015,共16页KANG Fengyu ZHOU Liang CHEN Wenqiang# HUANG Pingliang Amos Musyoki MAWIA LUO Ju HU Peisong 
supported by the National Major Science and Technology Program on New Genetically Modified Organism Variety Breeding,China(Grant No.2016ZX08001-001).
Rice leaf morphology is of great significance in the breeding of an ideal plant type and high photosynthetic efficiency.A forward genetics approach was employed to locate a novel gene,NRL9(NARROW AND ROLLED LEAF 9).NR...
关键词：BREEDING GRAIN ROW 
Proteomic insights from extracellular vesicles into the molecular mechanisms of health effects induced by Per-and polyfluoroalkyl substances
《Journal of Environmental Sciences》2025年第4期395-411,共17页Yanping Li Yadan Luo Yang Liu Na Li Kai Huang Lingxiangyu Li Zhigang Li Chao Han Nali Zhu Yawei Wang Guibin Jiang 
supported by the Key Research and Development Plan of Zhejiang Province(No.2021C03176);Zhejiang Provincial Natural Science Foundation of China(No.LY23B070001);the Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province(No.20230009);the National Natural Science Foundation of China(No.22106032);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750000).
Per-and polyfluoroalkyl substances(PFASs)can induce a range of adverse health effects,with the precise molecularmechanisms remaining elusive.Extracellular vesicles(EVs)have demonstrated their potential to elucidate un...
关键词：Per-and polyfluoroalkyl substances Extracellular vesicles Health effects PROTEOMICS PROTEASOME 
Cell-autonomous innate immunity by proteasome-derived defence peptides
《四川生理科学杂志》2025年第3期584-584,共1页Karin Goldberg 
For decades,antigen presentation on major histocompatibility complex class I for T cell-mediated immunity has been considered the primary function of proteasome-derived peptides1,2.However,whether the products of prot...
关键词：AUTONOMOUS CONSTITUTIVE MOUNT 
Overexpression pattern,function,and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma
《World Journal of Clinical Oncology》2025年第2期76-93,共18页Sheng-Sheng Zhou Yu-Ping Ye Yi Chen Da-Tong Zeng Guang-Cai Zheng Rong-Quan He Bang-Teng Chi Lei Wang Qian Lin Qin-Yan Su Yi-Wu Dang Gang Chen Jia-Liang Wei 
Supported by National Natural Science Foundation of China,No.82160762;Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine Scientific Research Project,No.GXZYA20230267;China Undergraduate Innovation and Entrepreneurship Training Program,No.S202410598060X;China Undergraduate Innovation and Entrepreneurship Training Program,No.X202410598360;Future Academic Star of Guangxi Medical University,No.WLXSZX24074.
BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant tumours.Unfortunately,there are no reports on th...
关键词：Hepatocellular carcinoma Proteasome 26S subunit non-ATPase 6 Clustered regularly interspaced short palindromic repeats Ribosome biogenesis RNA splicing 
Both 20S and 19S proteasome components are essential for meiosis in male mice
《Zoological Research》2025年第1期27-40,共14页Ting-Ting Han Li-Ying Wang Qiu-Xing Zhou Wei Wei Yan-Jie Ma Ying-Hong Chen Wei Li Zhen-Yu Ju Chao Liu 
supported by the National Science Fund for Distinguished Young Scholars (81925015);Science and Technology Project of Guangzhou (2023A03J0886,2023A03J0871);National Natural Science Foundation of China (82030039,32400709)。
The proteasome,an evolutionarily conserved proteolytic complex comprising the 20S core particle and 19S regulatory particles,performs both shared and distinct functions across various tissues and organs.Spermatogenesi...
关键词：PROTEASOME PSMA1 PSMD2 Meiotic initiation SPERMATOGENESIS 
Understanding neurodevelopmental proteasomopathies as new rare disease entities:A review of current concepts,molecular biomarkers,and perspectives
《Genes & Diseases》2024年第6期168-191,共24页Silvestre Cuinat Stephane Bezieau Wallid Deb Sandra Mercier Virginie Vignard Bertrand Isidor Sebastien Kury Frederic Ebstein 
supported by the European Joint Programme on Rare Diseases (EJP RD)for the project"UPS-NDDiag"and the Agence Nationale de la Recherche (ANR)for the project ANR-21-CE17-0005.
The recent advances in high throughput sequencing technology have drastically changed the practice of medical diagnosis,allowing for rapid identification of hundreds of genes causing human diseases.This unprecedented ...
关键词：Biomarkers Loss-of-function variants Neurodevelopmental disorders PROTEASOME Rare diseases Therapeutic targets 
Overexpression of proteasome 26S subunit non-ATPase 6 protein and its clinicopathological significance in intrahepatic cholangiocarcinoma被引量：1
《World Journal of Hepatology》2024年第11期1282-1289,共8页Zhong-Qing Tang Yu-Lu Tang Kai Qin Qi Li Gang Chen Yu-Bin Huang Jian-Jun Li 
BACKGROUND Currently,intrahepatic cholangiocarcinoma(ICC)poses a continuing,significant health challenge,but the relationship has yet to be established between ICC and the proteasome 26S subunit non-ATPase 6(PSMD6).AI...
关键词：Intrahepatic cholangiocarcinoma Proteasome 26S subunit non-ATPase 6 Immunohistochemistry Clustered regularly interspaced short palindromic repeat knockout screening Clinicopathological characteristics 
Selective recognition of PTRE1 transcripts mediated by protein-protein interaction between the m^(6)A reader ECT2 and PTRE1
《Plant Communications》2024年第11期144-156,共13页Li Yang Bo Wang Duanmu Zhao Xuechun Li Yifei Qin Ning Ouyang Zhili Xiao Zhibing Zhang Gad Galili Jiayang Li Hadas Peled-Zehavi Jian Wu 
Double first-class discipline promotion project(2021B10564001);Laboratory of Lingnan Modern Agriculture Project(NT2021001 and NG2021004).
N^(6)-methyladenosine (m^(6)A) is a prevalent internal post-transcriptional modification in eukaryotic RNAs executed by m^(6)A-binding proteins known as “readers.” Our previous research demonstrated that the Arabido...
关键词：ECT2 20S proteasome m^(6)A RNA protein interaction ARABIDOPSIS 
DIA-based quantitative proteomic analysis on porcine meat quality at different chilling rates
《Food Science and Human Wellness》2024年第5期2573-2583,共11页Yuqiang Bai Tongjing Yan Fei Fang Xin Li Su Wang Juan Li Chengli Hou Dequan Zhang 
support from the National Natural Science Foundation of China(32030086).
The objective of this study was to evaluate the effects of chilling rate on porcine meat quality from the perspective of proteome using data independent acquisition(DIA)-based quantitative proteomic strategy. M. longi...
关键词：Very fast chilling TENDERNESS PROTEOMIC GLYCOLYSIS PROTEASOME 
Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases被引量：1
《Signal Transduction and Targeted Therapy》2024年第8期3467-3482,共16页Zhan-Li Chen Chen Xie Wei Zeng Rui-Qi Huang Jin-E Yang Jin-Yu Liu Ya-Jing Chen Shi-Mei Zhuang 
This study was supported by grants from National Key R&D Program of China(2019YFA0906001 to S.M.Z.);National Natural Science Foundation of China(81930076 to S.M.Z.,32000494 to C.X.);Guangdong Basic and Applied Basic Research Foundation(2023A1515012301 to C.X.);Guangzhou Basic Research Project(2023A04J1753 to C.X.)。
Mitotic catastrophe(MC),which occurs under dysregulated mitosis,represents a fascinating tactic to specifically eradicate tumor cells.Whether pyroptosis can be a death form of MC remains unknown.Proteasome-mediated pr...
关键词：PROTEASOME INHIBITING CATASTROPHE 
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