Overexpression of proteasome 26S subunit non-ATPase 6 protein and its clinicopathological significance in intrahepatic cholangiocarcinoma  

作　　者：Zhong-Qing Tang Yu-Lu Tang Kai Qin Qi Li Gang Chen Yu-Bin Huang Jian-Jun Li 

机构地区：[1]Department of Pathology,Wuzhou Gongren Hospital/The Seventh Affiliated Hospital of Guangxi Medical University,Wuzhou 543000,Guangxi Zhuang Autonomous Region,China [2]Department of Pathology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China [3]Department of General Surgery,The Second Affiliated Hospital of Guangxi Medical University,Nanning 530007,Guangxi Zhuang Autonomous Region,China

出　　处：《World Journal of Hepatology》2024年第11期1282-1289,共8页世界肝病学杂志（英文）

摘　　要：BACKGROUND Currently,intrahepatic cholangiocarcinoma(ICC)poses a continuing,significant health challenge,but the relationship has yet to be established between ICC and the proteasome 26S subunit non-ATPase 6(PSMD6).AIM To investigate the protein expression and clinicopathological significance of PSMD6 in ICC.METHODS The potential impact of the PSMD6 gene on the growth of ICC cell lines was analyzed using clustered regularly interspaced short palindromic repeat knockout screening technology.Forty-two paired specimens of ICC and adjacent noncancerous tissues were collected.PSMD6 protein expression was determined by immunohistochemistry.Receiver operating characteristic curve analysis was performed to validate PSMD6 expression level,and its association with ICC patients’various clinicopathological characteristics was investigated.RESULTS The PSMD6 gene was found to be essential for the growth of ICC cell lines.PSMD6 protein was significantly overexpressed in ICC tissues(P<0.001),but showed no significant association with patient age,gender,pathological grade,or tumor-node-metastasis stage(P>0.05).CONCLUSION PSMD6 can promote the growth of ICC cells,thus playing a pro-oncogenic role.

关 键 词：Intrahepatic cholangiocarcinoma Proteasome 26S subunit non-ATPase 6 Immunohistochemistry Clustered regularly interspaced short palindromic repeat knockout screening Clinicopathological characteristics 

分 类 号：R735.8[医药卫生—肿瘤]