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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival
《Neural Regeneration Research》2025年第7期2108-2115,共8页Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie Na Han 
supported by the National Natural Science Foundation of China,No.81971177(to YK);the Natural Science Foundation of Beijing,No.7222198(to NH);the Peking University People's Hospital Research and Development Fund,No.RDX2021-01(to YK)。
FK506(Tacrolimus)is a systemic immunosuppressant approved by the U.S.Food and Drug Administration.FK506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways ...
关键词：FK506 inflammation motor neurons nerve regeneration NEURON peripheral nerve injury sensory neurons 
Mycobacterial antigen Ag85B restrains Hodgkin lymphoma tumor growth by inhibiting autophagy
《Oncology Research》2025年第5期1173-1187,共15页YONGFENG CHENG YIPING SHEN YUNFEI ZHANG HAILIQIGULI NURIDING XUEMEI WANG CHUNYAN FAN GULIBAHA MAIMAITI YU LIU YINGBIN YUE DANLU LI MEI YAN 
supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region of China(grant number 2022D01C739);the National Natural Science Foundation of China(grant numbers 82160031,82071276);the Key Research and Development Program of Xinjiang Uyghur Autonomous Region of China(grant number 2024B03038-1).
Background:The growth of the B-cell lymphoma subtype,Hodgkin lymphoma(HL),is associated with increased autophagy.A mycobacterial antigen,Ag85,has been reported to inhibit cell autophagy under a variety of conditions.W...
关键词：Hodgkin disease Mycobacterial antigen AUTOPHAGY Protein kinase B Mitogen-activated protein kinases 
Nintedanib regulates miR-23b-3p/TGFBR2 axis and competitively binds to TGFBR2 protein, inhibiting EMT process in human pterygium cells
《International Journal of Ophthalmology(English edition)》2025年第5期779-791,共13页Ke-Ke Zhang Meng Li Yan-Hong Liao Xiao-Tian Liu Yong-Bo Bao Yan Gong 
Supported by the Ningbo Natural Science Foundation(No.2023J212);Zhejiang Medical and Health Technology Program(No.2023KY1141).
AIM:To investigate the effects of nintedanib on epithelial-mesenchymal transition(EMT)in cells derived from pterygium,aiming to explore its potential as a pharmacological intervention for pterygium treatment.METHODS:P...
关键词：PTERYGIUM epithelial-mesenchymal transition nintedanib molecular docking CO-IMMUNOPRECIPITATION 
Shenfushu granules attenuate diabetic kidney disease by inhibiting PIK3R1/protein kinase B/heparanase-mediated endothelialmesenchymal transition
《World Journal of Diabetes》2025年第5期297-316,共20页Xi-Ding Yang Si-Jia Ma Da-Xiong Xiang Yong-Yu Yang 
Supported by the Changsha Science and Technology Major Project,No.kh2205035;the Hunan Traditional Chinese Medicine Science and Technology Project,No.2021061;the Natural Science Foundation of Hunan Province,No.2025JJ80080。
BACKGROUND Injury to the glomerular filtration barrier causes diabetic kidney disease(DKD),and glomerular endothelial-mesenchymal transition damages the filtration barrier of glomerular endothelial cells.Shenfushu gra...
关键词：Diabetic kidney disease Glomerular filtration barrier GLYCOCALYX Shenfushu granules PIK3R1 Heparanase-1 Endothelial-mesenchymal transition 
Hesperetin Relaxes Depolarizing Contraction in Human Umbilical Vein by Inhibiting L-Type Ca~(2+)Channel
《Chinese Journal of Integrative Medicine》2025年第5期412-421,共10页Kritsana Tipcome Wattana B.Watanapa Katesirin Ruamyod 
Supported by National Research Council of Thailand Thesis Grant for Doctoral Degree Student and the Siriraj Graduate Scholarship(both to K.T.);the Faculty of Medicine Siriraj Hospital,Mahidol University(to W.B.W.and K.R.)。
Objective:To study hesperetin-induced vasorelaxation after depolarizing contraction in human umbilical veins(HUVs)to elucidate the role of L-type Ca~(2+)channel(LTCC)and related signaling pathway.Methods:Isometric ten...
关键词：cardiovascular diseases NUCLEOTIDES cyclic HESPERETIN calcium channels L-TYPE PHOSPHODIESTERASE umbilical veins 
Dl-3-n-butylphthalide ameliorates diabetic foot ulcer by inhibiting apoptosis and promoting angiogenesis
《World Journal of Diabetes》2025年第4期252-269,共18页Wu-Han Wei Yuan-Ling Bai Dong Zhu Jing-Yu Zhang Qi-Chuan Yin Qiang Li Cai-Qi Shen Pei-Sheng Jin 
Supported by General Project of Xuzhou Science and Technology Bureau,No.KC22070.
BACKGROUND Diabetic foot ulcers(DFU)are estimated to affect about 18.6 million people worldwide annually.The pathogenesis of DFU is complex,and the available drugs are not effective.Dl-3-n-butylphthalide(NBP)is a synt...
关键词：Dl-3-n-butylphthalide Diabetic foot ulcer Network pharmacology ANGIOGENESIS APOPTOSIS 
BEND6 promotes RNA viruses'replication by inhibiting innate immune responses
《Science China(Life Sciences)》2025年第4期1073-1083,共11页Tong Chen Ling Ding Shaoyu Tu Huimin Sun Jiahui Zou Aotian Ouyang Meijun Jiang Yi Feng Meilin Jin Huanchun Chen Hongbo Zhou 
supported by the National Key Research and Development Program of China(2021YFD1800204);the National Natural Science Foundation of China(32025036);the Fundamental Research Funds for the Central Universities(2662023PY005);Hubei Hongshan Laboratory(2022hszd005);the earmarked fund for CARS-41;the Natural Science Foundation of Hubei Province(2021CFA016)。
Innate immunity serves as a crucial defense mechanism against invading pathogens,yet its negative regulatory network remains under explored.In this study,we identify BEN domain-containing protein 6(BEND6)as a novel ne...
关键词：innate immunity BEND6 RNAvirus IRF3 IFN-Β 
Xiaohuang Qudan decoction alleviates ANIT-induced cholestatic liver injury by inhibiting the JAK2/STAT3 pathway and regulating TH17/Treg
《Chinese Journal of Natural Medicines》2025年第4期457-470,共14页Zhangkui Tan Lifeng Chen Zhiqin Ye Qiping Lu 
supported by the Natural Science Foundation of Hubei Province(No.2022CFD020);the Postdoctoral Research Initiation Fund(No.20211015KY19);the Hubei Provincial Medical Young Top Talents[No.2019(48)]。
Xiaohuang Qudan decoction(XHQDD)is a classical traditional Chinese medicine(TCM)formula widely used in the treatment of cholestatic liver injury.Despite its widespread use,the protective mechanism of XHQDD against cho...
关键词：ANIT TH17/TREG Cholestatic liver injury Xiaohuang Qudan decoction JAK2/STAT3 UHPLC-MS/MS 
PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma
《Genes & Diseases》2025年第2期64-67,共4页Yue Weng Xiangyu Yan Biying Chen Zhouliang Bian Yunhui Ge Hong Lu Shufang He Jian Wu Yong Chen Ming Lei Yanjie Zhang 
supported by grants from the National Natural Science Foundation of China (No.31930063 to Ming Lei,82072638 to Yanjie Zhang,32100582 to Yunhui Ge);Innovative Research Team of High-level Local University in Shanghai,China (No.SHSMU-ZLCX20211700 to Ming Lei);Shanghai Municipal Health Commission and Collaborative Innovation Cluster Project (China) (No.2019CXJQ01 to Ming Lei).
Telomerase plays an essential role in the immortalization and stemness of cancer cells.PIN2/TRF1-interacting telomerase inhibitor 1(PinX1)functions as a telomerase inhibitor and tumor suppressor.1 However,the underlyi...
关键词：PinX1 CERVICAL CANCER 
LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis via miR-625-5p/SCL7A11 axis
《World Journal of Gastroenterology》2025年第16期49-65,共17页Qing Dai Tian-Yin Qu Jin-Lan Yang Jing Leng Lin Fang Qian-Qian Zhu Ke-Bi Wu Jie Wu Jing-Jing Ma Huang-Fei Yu 
Supported by the National Natural Science Foundation of China,No.81960506;Science and Technology Fund Project of Guizhou Provincial Health Commission,No.gzwkj2022-299;Key Projects of Zunyi Science and Technology Fund,No.zunshikeheHZzi(2023)24 and No.zunshikeheHZzi(2024)9.
BACKGROUND Radiotherapy is widely employed in colorectal cancer(CRC)treatment,but the occurrence of radioresistance severely limits the clinical benefit to patients and significantly contributes to treatment failure a...
关键词：Colorectal cancer LncRNA FTX Solute carrier family 7 member 11 Ferroptosis Redox RADIORESISTANCE 
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