GLYCOCALYX

作品数：21被引量：50H指数：5
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相关领域：医药卫生更多>>
相关作者：苏红韩雯雯许冬梅唐利军王尊松更多>>
相关机构：昆明医科大学山东省千佛山医院山东大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Reproductive and Developmental Medicine》《World Journal of Gastroenterology》《医用生物力学》更多>>
相关基金：国家自然科学基金江苏省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Shenfushu granules attenuate diabetic kidney disease by inhibiting PIK3R1/protein kinase B/heparanase-mediated endothelialmesenchymal transition
《World Journal of Diabetes》2025年第5期297-316,共20页Xi-Ding Yang Si-Jia Ma Da-Xiong Xiang Yong-Yu Yang 
Supported by the Changsha Science and Technology Major Project,No.kh2205035;the Hunan Traditional Chinese Medicine Science and Technology Project,No.2021061;the Natural Science Foundation of Hunan Province,No.2025JJ80080。
BACKGROUND Injury to the glomerular filtration barrier causes diabetic kidney disease(DKD),and glomerular endothelial-mesenchymal transition damages the filtration barrier of glomerular endothelial cells.Shenfushu gra...
关键词：Diabetic kidney disease Glomerular filtration barrier GLYCOCALYX Shenfushu granules PIK3R1 Heparanase-1 Endothelial-mesenchymal transition 
Sulfated liposome-based artificial cell membrane glycocalyx nanodecoys for coronavirus inactivation by membrane fusion
《Bioactive Materials》2024年第3期1-13,共13页Xu Li Ningtao Cheng Danrong Shi Yutong Li Chen Li Miaojin Zhu Qiao Jin Zhigang Wu Linwei Zhu Yi He Hangping Yao Jian Ji 
supported by the National Key Research&Development Program of China(No.2021YFC2301204);Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(2022SZ-TD010);the Fundamental Research Funds for the Central Universities(No.2022ZFJH003).We thank Lingyun Wu in the Center of Cryo-Electron Microscopy(CCEM),Zhejiang University for her technical assistance on Cryo-EM.
As a broad-spectrum antiviral nanoparticle,the cell membrane nanodecoy is a promising strategy for preventing viral infections.However,most of the cell membrane nanodecoys can only catch virus and cannot induce inacti...
关键词：Antiviral nanoparticle Cell membrane nanodecoy CORONAVIRUS Viral inactivation 
Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity
《Cellular & Molecular Immunology》2023年第8期955-968,共14页Manuel M.Vicente Inês Alves Ângela Fernandes Ana M.Dias Beatriz Santos-Pereira Elena Pérez-Anton Sofia Santos Tao Yang Alexandra Correia Anja Münster-Kühnel Afonso R.M.Almeida Sarina Ravens Gabriel A.Rabinovich Manuel Vilanova Ana E.Sousa SaloméS.Pinho 
Funded by the“2022 Lupus Research Alliance(LRA)Lupus Innovation Award”.Institutional funding from the Portuguese Foundation for Science and Technology(FCT):projects NORTE-01-0145-FEDER-000029,POCI-01/0145-FEDER-016601,POCI-01-0145-FEDER-028772,and PTDC/MEC-REU/28772/2017(SSP);This study was co-funded by the European Union(ERC Synergy,GlycanSwitch,101071386);Views and opinions expressed are,however,those of the author(s)only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency.The study was also co-funded by the European Union,GlycanTrigger project,Grant Agreement No:101093997;Views and opinions expressed are,however,those of the author(s)only and do not necessarily reflect those of the European Union or European Health and Digital Executive Agency.Neither the European Union nor the granting authority can be held responsible for them.A grant was received from the Portuguese group of study in autoimmune diseases(NEDAI)to SSP.MMV(PD/BD/135452/2017,COVID/BD/152488/2022)received funding from the FCT.
T-cell development ensures the formation of diverse repertoires of T-cell receptors(TCRs)that recognize a variety of antigens.Glycosylation is a major posttranslational modification present in virtually all cells,incl...
关键词：N-glycosylation T-cell development THYMOCYTES GLYCOCALYX Inflammation 
Early diabetic kidney disease:Focus on the glycocalyx
《World Journal of Diabetes》2023年第5期460-480,共21页Hui Yu Yi-Yun Song Xian-Hua Li 
Supported by the Natural Science Foundation of Shandong Province of China,No.ZR2019MH072.
The incidence of diabetic kidney disease(DKD)is sharply increasing worldwide.Microalbuminuria is the primary clinical marker used to identify DKD,and its initiating step in diabetes is glomerular endothelial cell dysf...
关键词：GLYCOCALYX Diabetic kidney disease Endothelial cells Reactive oxygen species MICROALBUMINURIA ENZYME 
HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium被引量：1
《World Journal of Gastroenterology》2022年第29期3886-3902,共17页Nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García Norma Velázquez-Guadarrama 
Supported by the Federal Funds,HIM/2009/037.SSA851 and HIM/2014/012.SSA 1098;the grant from Secretaría de Investigación y Posgrado,SIP 20161878;the Instituto Politécnico Nacional by Consejo Nacional de Ciencia y Tecnología,CB-222180.
BACKGROUND The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are vari...
关键词：Hypothetical protein HP0953 ADHERENCE Helicobacter pylori GLYCOCALYX Virulence factor PERSISTENCE 
Resuscitation fluids as drugs:targeting the endothelial glycocalyx被引量：5
《Chinese Medical Journal》2022年第2期137-144,共8页Guangjian Wang Hongmin Zhang Dawei Liu Xiaoting Wang Chinese Critical Ultrasound Study Group 
Fluid resuscitation is an essential intervention in critically ill patients,and its ultimate goal is to restore tissue perfusion.Critical illnesses are often accompanied by glycocalyx degradation caused by inflammator...
关键词：Fluid resuscitation Resuscitation fluid Fluid therapy Endothelial glycocalyx GLYCOCALYX 
Durable endothelium-mimicking coating for surface bioengineering cardiovascular stents被引量：6
《Bioactive Materials》2021年第12期4786-4800,共15页Qing Ma Xiuying Shi Xing Tan Rui Wang Kaiqin Xiong Manfred F.Maitz Yuanyuan Cui Zhangmei Hu Qiufen Tu Nan Huang Li Shen Zhilu Yang 
This work was supported by the National Natural Science Foundation of China(Project 82072072);International Cooperation Project by Science and Technology Department of Sichuan Province(2021YFH0056,2019YFH0103);the Fundamental Research Funds for the Central Universities(2682020ZT82,2682020ZT76).
Mimicking the nitric oxide(NO)-release and glycocalyx functions of native vascular endothelium on cardiovascular stent surfaces has been demonstrated to reduce in-stent restenosis(ISR)effectively.However,the practical...
关键词：Cardiovascular stents Nitric oxide Glycocalyx component Endothelium mimicking Surface bioengineering 
The Influence of Remote Ischemic Conditioning on Focal Brain Ischemia in Rats
《Journal of Behavioral and Brain Science》2021年第6期131-142,共12页Maria E. Kolpakova Anastasia A. Yakovleva Ludmila S. Polyakova 
Despite obvious progress in the treatment of acute forms of ischemic stroke, the risk of this condition remains unacceptably high. Brain infarction in the middle cerebral artery basin occurs in patients with atheroscl...
关键词：Stroke Brain Infarction ISCHEMIA-REPERFUSION SYNDECAN-1 GLYCOCALYX Endothelial Dysfunction Middle Cerebral Artery Occlusion (MCAO) Remote Ischemic Conditioning (RIC) 
Neutrophil-derived heparin binding protein triggers vascular leakage and synergizes with myeloperoxidase at the early stage of severe burns(With video)被引量：9
《Burns & Trauma》2021年第1期240-254,共15页Lu Liu Yiming Shao Yixuan Zhang Yunxi Yang Jiamin Huang Linbin Li Ran Sun Yuying Zhou Yicheng Su Bingwei Sun 
supported by the National Natural Science Founda-tion of China,No.82072217,81772135;the Jiangsu Natural Science Foundation,No.BK20201178。
Background:Burn shock caused by vascular leakage is one of the main causes of high mortality in severe burn injury.However,the pathophysiological mechanism of vascular leakage is still unclear.The purpose of this stud...
关键词：Severe burn Heparin binding protein MYELOPEROXIDASE Vascular leakage GLYCOCALYX 
Vascular Endothelial Glycocalyx as a Mechanism of Vascular Endothelial Dysfunction and Atherosclerosis被引量：2
《World Journal of Cardiovascular Diseases》2020年第10期731-749,共19页Minako Yamaoka-Tojo 
Atherosclerosis occurs as a result of organized processes that include vascular endothelial dysfunction, lipid accumulation, abnormal inflammatory reaction, excessive reactive oxygen species production, and vascular c...
关键词：Vascular Endothelial Function INFLAMMATION Oxidative Stress Cardiovascular Disease Prevention Disease Management 
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