MYELOPEROXIDASE

作品数：75被引量：248H指数：9
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相关领域：医药卫生更多>>
相关作者：吴冬周荣胡德耀周学武罗俊更多>>
相关机构：南京诺尔曼生物技术有限公司成都市妇女儿童中心医院台州市中心医院第三军医大学更多>>
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Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response
《Science China Chemistry》2025年第1期273-287,共15页Shuguang Yang Lijun Hu Hong Xiao Zecong Xiao Xintao Shuai 
supported by the Key Areas Research and Development Program of Guangzhou(202007020006);the National Natural Science Foundation of China(51933011,31971296,82102194,82302360);the Science and Technology Projects of Guangzhou(2023A03J0215);the Guangdong Basic Research Center of Excellence for Functional Molecular Engineering。
Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy.Nonetheless,the optimization of the catal...
关键词：fluorescent molecular probes self-amplifying MYELOPEROXIDASE photodynamic therapy 
NADPH oxidase 4(NOX4)as a biomarker and therapeutic target in neurodegenerative diseases被引量：2
《Neural Regeneration Research》2024年第9期1961-1966,共6页Napissara Boonpraman Sun Shin Yi 
supported by the National Research Foundation of the Republic of Korea 2018R1D1A3B07047960;the Soonchunhyang University Research Fund(to SSY).
Diseases like Alzheimer’s and Parkinson’s diseases are defined by inflammation and the damage neurons undergo due to oxidative stress. A primary reactive oxygen species contributor in the central nervous system, NAD...
关键词：Alzheimer’s disease ASTROCYTES mitochondrial dysfunction MYELOPEROXIDASE NADPH oxidase 4 NADPH oxidase 4 inhibitors neurodegenerative diseases OSTEOPONTIN Parkinson’s disease reactive oxygen species 
Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients
《Precision Clinical Medicine》2024年第2期93-108,共16页Andrei Kudriavtsev Brice Pastor Alexia Mirandola Ekaterina Pisareva Yann Gricourt Xavier Capdevila Alain R.Thierry Philippe Cuvillon 
grant NIMAO 2016-08 and partiallyysupportedbySIRIC MontpellieCr ancerGrant INCa_Inserm_DGOS_12553 and the"SociétéFrancaise des acides nucléiques circulants"(SFAC).The promotor of this study is the Centre Hospitalier Universitaire de Nimes.The authors thank Cormac Mc Carthy(Mc Carthy Consultant,Montpellier)for English editing(financial compensation).We thank our patients and their families for their trust;and all the participating physicians and supporting staff.We thank all healthy donors who participated in this study.We also thank the clinical investigators of the centers who participated in this study.
Objectives:Elevated circulating DNA(cirDNA)concentrations were found to be associated with trauma or tissue damage which suggests involvement of inflammation or cell death in post-operative cirDNA release.We carried o...
关键词：circulating DNA perioperative period neutrophil extracellular traps neutrophil elastase MYELOPEROXIDASE minimal residualdisease 
Carbamylated lipoproteins in diabetes被引量：2
《World Journal of Diabetes》2023年第3期159-169,共11页Damien Denimal 
Diabetic dyslipidemia is characterized by quantitative and qualitative abnormalities in lipoproteins.In addition to glycation and oxidation,carbamylation is also a post-translational modification affecting lipoprotein...
关键词：CARBAMYLATION LIPOPROTEIN DIABETES Low-density lipoprotein High-density lipoprotein MYELOPEROXIDASE 
Pathologically triggered in situ aggregation of nanoparticles for inflammation-targeting amplification and therapeutic potentiation被引量：3
《Acta Pharmaceutica Sinica B》2023年第1期390-409,共20页Qiang Nie Chenwen Li Yu Wang Yi Hu Wendan Pu Qixiong Zhang Jiajun Cai Yongyao Lin Gang Li Chenping Wang Lanlan Li Yin Dou Jianxiang Zhang 
supported by the National Natural Science Foundation of China(No.81971727);the Program for Postdoctoral Innovative Talent of Chongqing(China);the Program for Scientific and Technological Innovation Leader of Chongqing(No.CQYC20210302362,China);the Program for Distinguished Young Scholars of TMMU(China)。
Uncontrolled and persistent inflammation is closely related to numerous acute and chronic diseases.However,effective targeting delivery systems remain to be developed for precision therapy of inflammatory diseases.Her...
关键词：Inflammatory disease Reactive oxygen species MYELOPEROXIDASE Targeted therapy NANOPARTICLES Surface engineering Triggerable aggregation Nanotherapy 
Acetyl-11-keto-beta-boswellic acid promotes sciatic nerve repair after injury: molecular mechanism被引量：2
《Neural Regeneration Research》2022年第12期2778-2784,共7页Yao Wang Zong-Liang Xiong Xiang-Lin Ma Chong Zhou Mo-Han Huo Xiao-Wen Jiang Wen-Hui Yu 
supported by the National Natural Science Foundation of China, No.31972725(to WHY)
Previous studies showed that acetyl-11-keto-beta-boswellic acid(AKBA),the active ingredient in the natural Chinese medicine Boswellia,can stimulate sciatic nerve injury repair via promoting Schwann cell proliferation....
关键词：AKBA AXON genomics inflammatory injury and repair myelin sheath MYELOPEROXIDASE neurotrophic factor peripheral nerve phagosome pathway regeneration Sprague-Dawley rat 
Myeloperoxidase: a new target for the treatment of stroke?被引量：1
《Neural Regeneration Research》2022年第8期1711-1716,共6页Yun-Chang Wang Yu-Bao Lu Xiao-Lan Huang Yong-Feng Lao Lu Zhang Jun Yang Mei Shi Hai-Long Ma Ya-Wen Pan Yi-Nian Zhang 
supported by the National Natural Science Foundation of China,No.81771297(to YNZ);CuiYing Scientific and Technological Innovation Program of Lanzhou University Second Hospital of China,No.CY2017-MS04(to YNZ);Hui-Chun Chin and Tsung-Dao Lee Chinese Undergraduate Research Endowment of China,No.LZU-JZH2224(to YCW);National Innovation and Entrepreneurship Training Program for Undergraduate of China,No.201910730212(to YCW);CuiYing Scientific Training Program for Undergraduates of Lanzhou University Second Hospital of China,No.CYXZ2019-06(to YCW).
Myeloperoxidase is an important inflammatory factor in the myeloid system,primarily expressed in neutrophils and microglia.Myeloperoxidase and its active products participate in the occurrence and development of hemor...
关键词：blood-brain barrier hemorrhagic stroke INFLAMMATION ischemic stroke MICROGLIA MYELOPEROXIDASE NEUTROPHILS secondary brain injury STROKE 
Heme perbxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine
《Chinese Journal of Natural Medicines》2022年第3期194-201,共8页WANG You-Xu CAO Ning GUAN Hui-Da CHENG Xue-Mei WANG Chang-Hong 
supported by the National Natural Science Foundation of China(Nos.82173885 and 81872933);the National Natural Science Foundation of Xinjiang Uyghur Autonomous Region of China(No.U1130303);the Technology Cooperation Projects of Science in Shanghai,China(No.20015800100);the Key Laboratory Open Project of Xinjiang Uyghur Autonomous Region(No.2019D04018).
Harmaline and harmine areβ-carboline alkaloids with effective pharmacological effects.Harmaline can be transformed into harmine after oral administration.However,enzymes involved in the metabolic pathway remain uncle...
关键词：HARMALINE HARMINE Oxidative dehydrogenation Heme peroxidases MYELOPEROXIDASE Horseradish peroxidase LACTOPEROXIDASE 
Functional annotation and enrichment analysis of differentially expressed serum proteins in patients with type 2 diabetes after dapagliflozin被引量：1
《World Journal of Diabetes》2022年第3期224-239,共16页Yan-Xue Zhao Sarul Borjigin Zhao-Li Yan 
Supported by Major Scientific Research Program of The Affiliated Hospital of Inner Mongolia Medical University,No. NYFY ZD 001
BACKGROUND Only 50% of patients with type 2 diabetes mellitus(T2DM) can control their blood glucose levels. Dapagliflozin is a selective inhibitor of sodium-glucose cotransporter 2(SGLT-2) that improves the insulin se...
关键词：Type 2 diabetes mellitus DAPAGLIFLOZIN Non-standard quantitative proteomics MYELOPEROXIDASE Alpha II B integrin PODOCALYXIN 
Severe Pulmonary Embolism,Thrombosis of Lower Extremity,Unexpected Mild Renal Disorder in MPO-ANCA Associated Vasculitis:A Case Report
《Chinese Medical Sciences Journal》2021年第4期342-345,共4页Zhonghua Liao Juntao Feng Jiale Tang Liying Luo Xiaozhao Li 
Myeloperoxidase antineutrophil cytoplasmic antibody(MPO-ANCA)associated vasculitis is an autoimmune disease usually with severe multiple dysfunction syndrome,especially prominent acute renal failure.A 65-year-old woma...
关键词：antineutrophil cytoplasmic antibody-associated vasculitis MYELOPEROXIDASE pulmonary embolism arterial embolism 
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