Severe Pulmonary Embolism,Thrombosis of Lower Extremity,Unexpected Mild Renal Disorder in MPO-ANCA Associated Vasculitis:A Case Report  

1例严重肺及下肢血管栓塞并轻微肾损害的髓过氧化物酶阳性的抗中性粒细胞胞浆抗体相关性血管炎:病例报告

作　　者：Zhonghua Liao Juntao Feng Jiale Tang Liying Luo Xiaozhao Li 廖中华;冯俊涛;唐家乐;罗丽颖;李晓照(中南大学湘雅医院肾病内科;中南大学湘雅医院呼吸与危重症医学科)

机构地区：[1]Department of Nephrology,National Key Clinical Specialty,Branch of National Clinical Research Center for Respiratory Disease,Xiangya Hospital,Central South University,Changsha 410008,China [2]Department of Respiratory and Critical Care Medicine,National Key Clinical Specialty,Branch of National Clinical Research Center for Respiratory Disease,Xiangya Hospital,Central South University,Changsha 410008,China

出　　处：《Chinese Medical Sciences Journal》2021年第4期342-345,共4页中国医学科学杂志（英文版）

摘　　要：Myeloperoxidase antineutrophil cytoplasmic antibody(MPO-ANCA)associated vasculitis is an autoimmune disease usually with severe multiple dysfunction syndrome,especially prominent acute renal failure.A 65-year-old woman was admitted with progressive dyspnoea for six months and fever,sputum with blood,pain of the lower extremities and intermittent claudication for two days,indicating multiple organ involvement(respiratory system,blood vessels).The renal involvement was relatively mild,presenting with microscopic haematuria.The chest computed tomography demonstrated multiple pulmonary embolisms.Ultrasound and computed tomography angiography for the lower extremity vessels showed venous and arterial thrombosis.Exclusion of other diseases that can cause multiple organ damage and thrombosis,the positive perinuclear ANCA and MPO-ANCA strongly support the diagnosis of MPO-ANAC-associated vasculitis.The patient’s physical condition has been greatly improved by treatment with corticosteroids and anticoagulation.

关 键 词：antineutrophil cytoplasmic antibody-associated vasculitis MYELOPEROXIDASE pulmonary embolism arterial embolism 

分 类 号：R593.2[医药卫生—内科学] R692.5[医药卫生—临床医学]