ASTROCYTES

作品数：377被引量：1336H指数：16
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相关领域：医药卫生生物学更多>>
相关作者：宋伟刘璇刘颖孙景军叶诸榕更多>>
相关机构：中国科学院华中科技大学复旦大学北京大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>
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Metabolic reprogramming of astrocytes:Emerging roles of lactate
《Neural Regeneration Research》2026年第2期421-432,共12页Zeyu Liu Yijian Guo Ying Zhang Yulei Gao Bin Ning 
supported by the National Natural Science Foundation of China,Nos.82071383,82371392(to BN);the Natural Science Foundation of Shandong Province of China(Key Project),No.ZR2020KH007(to BN);“Taishan Scholar Distinguished Expert Program”of Shandong Province,No.tstp20231257(to BN);Health Commission Science and Technology Plan Project of Jinan,No.2023-1-8(to YZ).
Lactate serves as a key energy metabolite in the central nervous system,facilitating essential brain functions,including energy supply,signaling,and epigenetic modulation.Moreover,it links epigenetic modifications wit...
关键词：ASTROCYTE epigenetic modifications inflammation LACTATE lactylation METABOLIC PLASTICITY regeneration treatment 
Targeting the brain’s glymphatic pathway:A novel therapeutic approach for cerebral small vessel disease
《Neural Regeneration Research》2026年第2期433-442,共10页Yuhui Ma Yan Han 
supported by the National Natural Science Foundation of China,No.82274304(to YH);the Major Clinical Study Projects of Shanghai Shenkang Hospital Development Center,No.SHDC2020CR2046B(to YH);Shanghai Municipal Health Commission Talent Plan,No.2022LJ010(to YH).
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological me...
关键词：AQUAPORIN-4 ASTROCYTES cerebral amyloid angiopathy cerebral small vessel disease cerebrospinal fluid diffusion tensor image analysis along the perivascular space glymphatic system interstitial fluid perivascular space therapeutic strategies 
Optogenetic approaches for neural tissue regeneration:A review of basic optogenetic principles and target cells for therapy
《Neural Regeneration Research》2026年第2期521-533,共13页Davletshin Eldar Sufianov Albert Ageeva Tatyana Sufianova Galina Rizvanov Albert Mukhamedshina Yana 
supported by a grant from the Russian Science Foundation,No.23-75-10041(to MY)。
Optogenetics has revolutionized the field of neuroscience by enabling precise control of neural activity through light-sensitive proteins known as opsins.This review article discusses the fundamental principles of opt...
关键词：adeno-associated virus ASTROCYTES bioluminescent optogenetics channelrhodopsins halorhodopsins MICROGLIA neural stem cells NEURONS OLIGODENDROCYTE OPTOGENETICS 
Epilepsy therapy beyond neurons: Unveiling astrocytes as cellular targets
《Neural Regeneration Research》2026年第1期23-38,共16页Yuncan Chen Jiayi Hu Ying Zhang Lulu Peng Xiaoyu Li Cong Li Xunyi Wu Cong Wang 
supported by the National Key Research and Development Program of China,No. 2023YFF0714200 (to CW);the National Natural Science Foundation of China,Nos. 82472038 and 82202224 (both to CW);the Shanghai Rising-Star Program,No. 23QA1407700 (to CW);the Construction Project of Shanghai Key Laboratory of Molecular Imaging,No. 18DZ2260400 (to CW);the National Science Foundation for Distinguished Young Scholars,No. 82025019 (to CL);the Greater Bay Area Institute of Precision Medicine (Guangzhou)(to CW)。
Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the ...
关键词：ASTROCYTE cellular microenvironment drug resistance EPILEPSY EXCITABILITY homeostasis metabolism neural networks NEUROINFLAMMATION neuron 
Targeting the glymphatic system to promoteα-synuclein clearance:a novel therapeutic strategy for Parkinson's disease
《Neural Regeneration Research》2026年第1期233-247,共15页Xiaoyue Lian Zhenghao Liu Zuobin Gan Qingshan Yan Luyao Tong Linan Qiu Yuntao Liu Jiang-fan Chen Zhihui Li 
supported by the National Natural Science Foundation of China,No.81971031(to ZL);the National Key Research and Development Program of China,No.2022YFE0210100(to JFC);the National Natural Science Foundation of China(Original Exploration Project),No.82151308(to JFC);the National Natural Science Foundation of China(Research Fund for International Senior Scientists),No.82150710558(to JFC);Science&Technology Initiative STI2030-Major Projects,No.2021ZD0203400(to JFC);Key Research and Development Program of Zhejiang Province,No.2023C03079(to JFC);Scientific Research Starting Foundation of Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine,Vision and Brain Health),No.OJQDSP2022007(to JFC);Project of State Key Laboratory of Ophthalmology,Optometry and Visual Science,Wenzhou Medical University,No.J01-20190101(to JFC);Scientific Research Starting Foundation of Wenzhou Medical University,No.QTJ12003(to JFC);Department of Science and Technology of Zhejiang Province,No.2023ZY1011(to JFC)。
The excessive buildup of neurotoxicα-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease,highlighting the urgent need for innovative therapeutic strategies to promoteα-synuclein clearance,parti...
关键词：AQUAPORIN-4 ASTROCYTES cerebrospinal fluid glymphatic system interstitial fluid neurotoxic protein clearance Parkinson's disease perivascular spaces sleep disturbance Α-SYNUCLEIN 
Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease:lessons from animal studies
《Neural Regeneration Research》2025年第12期3461-3475,共15页Wouter Claeys Anja Geerts Lien Van Hoecke Christophe Van Steenkiste Roosmarijn E.Vandenbroucke 
supported by grants from the Research Foundation–Flanders(11A6420N,1268823N to WC and LVH);a FWO Junior Research Project Grant(G055121N to REV);VIB.AG is a senior clinical researcher of the Research Foundation–Flanders(1805718N)。
Hepatic encephalopathy,defined as neuropsychiatric dysfunction secondary to liver disease,is a frequent decompensating event in cirrhosis.Its clinical impact is highlighted by a notable increase in patient mortality r...
关键词：AMMONIA ASTROCYTES CIRRHOSIS hepatic encephalopathy MICROGLIA NEUROINFLAMMATION osmotic stress oxidative stress systemic inflammation 
Decline and fall of aging astrocytes:the human perspective
《Neural Regeneration Research》2025年第6期1713-1714,共2页Alexei Verkhratsky Alexey Semyanov 
“Last scene of all that ends this strange,eventful history,is second childishness and mere oblivion.I am sans teeth,sans eyes,sans taste,sans everything.”William Shakespeare‘As You Like It'Act 2,Sc.7,l.139Aging of ...
关键词：AGING teeth PROGRESSIVE 
Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior
《Neural Regeneration Research》2025年第6期1721-1734,共14页Xirong Xu Shoumin Xuan Shuai Chen Dan Liu Qian Xiao Jie Tu 
supported by the National Natural Science Foundation of China,Nos.32371070 (to JT),31761163005 (to JT),32100824 (to QX);the Shenzhen Science and Technology Program,Nos.RCBS20210609104606024 (to QX),JCY20210324101813035 (to DL);the Guangdong Provincial Key S&T Program,No.2018B030336001 (to JT);the Key Basic Research Program of Shenzhen Science and Technology Innovation Commission,Nos.JCYJ20200109115405930 (to JT),JCYJ20220818101615033 (to DL),JCYJ20210324115811031 (to QX),JCYJ20200109150717745 (to QX);Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases,No.ZDSYS20220304163558001 (to JT);Guangdong Provincial Key Laboratory of Brain Connectome and Behavior,No.2023B1212060055 (to JT);the China Postdoctoral Science Foundation,No.2021M693298 (to QX)。
The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain functio...
关键词：ANXIETY ASTROCYTES basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry GLUTAMATE LDN-212320 TRANSPORTER 
Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders
《Neural Regeneration Research》2025年第5期1258-1276,共19页Qing Qiu Mengting Yang Danfeng Gong Haiying Liang Tingting Chen 
supported by the National Natural Science Foundation of China,Nos.81901098(to TC),82201668(to HL);Fujian Provincial Health Technology Project,No.2021QNA072(to HL)。
The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central n...
关键词：ASTROCYTES calcium channels central nervous system extracellular ion concentration MICROGLIA neurological disorders NEURONS potassium channels 
A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia
《Acta Pharmacologica Sinica》2025年第4期852-866,共15页Wei Tang Rong Cheng Meng-yue Gao Min-jin Hu Lu Zhang Qiang Wang Xin-yu Li Wei Yan Xiao-ying Wang Hai-mei Yang Jian Cheng Zi-chun Hua 
supported by the National Natural Science Foundation of China(82071469,32271033);the Priority Academic Program Development of the Jiangsu Higher Education Institutions(PAPD);Jiangsu Department of Science and Technology(BK20230164,BK20230165,BE2023695,BK20231136 and BK20243001);Changzhou Municipal Department of Science and Technology(2022169,CJ2023001,CJ20220019,and CJ20235009);the Suzhou Clinical Research Center of Neurological Disease(Szzx201503)and the Jiangsu Key Laboratory Grant(BM2013003).
Despite the vital role of astrocytes in preserving blood-brain barrier(BBB)integrity,their therapeutic potential as targets in ischemic stroke-induced barrier disruption remains underexplored.We previously reported ex...
关键词：cerebral ischemia blood-brain barrier ASTROCYTES PHOSPHATIDYLSERINE Annexin A5 
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