PHOSPHATIDYLSERINE

作品数：36被引量：75H指数：4
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相关领域：医药卫生生物学更多>>
相关期刊：《Cellular & Molecular Immunology》《Grain & Oil Science and Technology》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金以色列科学基金更多>>
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A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia
《Acta Pharmacologica Sinica》2025年第4期852-866,共15页Wei Tang Rong Cheng Meng-yue Gao Min-jin Hu Lu Zhang Qiang Wang Xin-yu Li Wei Yan Xiao-ying Wang Hai-mei Yang Jian Cheng Zi-chun Hua 
supported by the National Natural Science Foundation of China(82071469,32271033);the Priority Academic Program Development of the Jiangsu Higher Education Institutions(PAPD);Jiangsu Department of Science and Technology(BK20230164,BK20230165,BE2023695,BK20231136 and BK20243001);Changzhou Municipal Department of Science and Technology(2022169,CJ2023001,CJ20220019,and CJ20235009);the Suzhou Clinical Research Center of Neurological Disease(Szzx201503)and the Jiangsu Key Laboratory Grant(BM2013003).
Despite the vital role of astrocytes in preserving blood-brain barrier(BBB)integrity,their therapeutic potential as targets in ischemic stroke-induced barrier disruption remains underexplored.We previously reported ex...
关键词：cerebral ischemia blood-brain barrier ASTROCYTES PHOSPHATIDYLSERINE Annexin A5 
C176-loaded and phosphatidylserine-modified nanoparticles treat retinal neovascularization by promoting M2 macrophage polarization
《Bioactive Materials》2024年第9期392-405,共14页An Shao Lulu Jin Yanni Ge Ziqiang Ye Mingyu Xu Yifan Zhou Yingyu Li Linyan Wang Pinglong Xu Kai Jin Zhengwei Mao Juan Ye 
supported by Key Program of the National Natural Science Foundation of China(82330032);Natural Science Foundation of China(82201195);National Natural Science Foundation Regional Innovation and Development Joint Fund(U20A20386);Key Research and Development Program of Zhejiang Province(2024C03204).
Retinal neovascularization(RNV),a typical pathological manifestation involved in most neovascular diseases,causes retinal detachment,vision loss,and ultimately irreversible blindness.Repeated intravitreal injections o...
关键词：Retinal neovascularization Macrophage polarization cGAS-STING pathway NANOCARRIER 
Dietary Lipid Intervention in the Prevention of Brain Aging
《Engineering》2024年第6期128-137,共10页Wei Xiong Bing Fang Xiaoyu Wang Ming Zhang Min Du Jiazeng Sun Juan Chen Yixuan Li Changhao Sun Xingen Lei Xue Zhang Fazheng Ren 
supported by the National Key Research and Development Program of China(2022YFD2101003);the 111 Project from the Ministry of Education of the People’s Republic of China(B18053).
As people live longer,the burden of aging-related brain diseases,especially dementia,is increasing.Brain aging increases the risk of cognitive impairment,which manifests as a progressive loss of neuron function caused...
关键词：Brain aging Nutritional intervention PHOSPHOLIPIDS PHOSPHATIDYLCHOLINE PHOSPHATIDYLSERINE PLASMALOGEN 
A mix & act liposomes of phospholipase A2-phosphatidylserine for acute brain detoxification by blood‒brain barrier selective-opening被引量：1
《Acta Pharmaceutica Sinica B》2024年第4期1827-1844,共18页Zinan Zhang Wenbin Cao Huanchun Xing Shuai Guo Lijuan Huang Lin Wang Xin Sui Kui Lu Yuan Luo Yongan Wang Jun Yang 
In the treatment of central nervous system disease,the blood-brain barrier(BBB)is a major obstruction to drug delivery that must be overcome.In this study,we propose a brain-targeted delivery strat-egy based on select...
关键词：Liposomes Phospholipase A2 PHOSPHOSERINE Blood-brainbarrier Selectively open Mix&act 
Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies被引量：1
《Cancer Biology & Medicine》2024年第4期331-346,共16页Shuangcheng Li Tianci Wang Xinghui Xiao Xiaodong Zheng Haoyu Sun Rui Sun Hongdi Ma Zhigang Tian Xiaohu Zheng 
supported by the National Key R&D Program of China (2019YFA0508502/3 and 2021YFC2300604);the Natural Science Foundation of China (Reference numbers 82388201, 82241216, and 32270963);the Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM (QYZD20220008);the Anhui Key Research and Development Plan (Reference number 2023z04020011)。
Objective: The human cluster of differentiation(CD)300A, a type-I transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential immune checkpoint for human natural killer(...
关键词：NK cell CD300A PHOSPHATIDYLSERINE immune checkpoint hematologic malignancy 
Aptasensing biosynthesized phosphatidylserine with a AuNPs nanozyme-based colorimetric aptasensor
《Food Science and Human Wellness》2024年第2期823-829,共7页Sai Wang Rui Ma Chengqiang Li Ling Zhang Haiyang Zhang Xuehan Li Xiangzhao Mao 
supported by the National Natural Science Foundation of China(31922072);the Natural Science Foundation of Shandong Province(ZR2020JQ15);the Taishan Scholar Project of Shandong Province(tsqn201812020)。
Sensitive monitoring of the target products during the biosynthesis process is crucial,and facile analytical approaches are urgently needed.Herein,phosphatidylserine(PS)was chosen as the model target,a colorimetric ap...
关键词：PHOSPHATIDYLSERINE Chimeric aptamer AuNPs nanozyme Colorimetric aptasensor 
Phosphatidylserine:An overview on functionality,processing techniques,patents,and prospects
《Grain & Oil Science and Technology》2023年第4期206-218,共13页Jingnan Chen Jun Li Haoyu Xu Jiaxi Li Yonghong Yuan Xuebing Xu Yanlan Bi 
financially supported by the Innovative Funds Plan of Henan University of Technology(2020ZKCJ10);Cultivation Programme for Young Backbone Teachers in Henan University of Technology.
Phosphatidylserine(PS)is the part of cell structure in the body and has many beneficial functions especially in brain-related aging diseases.Although daily foods can provide PS to human body,the amount is very limited...
关键词：PHOSPHATIDYLSERINE FUNCTIONALITY Processing techniques Patents evaluation PROSPECTS 
B1-cell-produced anti-phosphatidylserine antibodies contribute to lupus nephritis development via TLR-mediated Syk activation被引量：3
《Cellular & Molecular Immunology》2023年第8期881-894,共14页Kongyang Ma Wenhan Du Shiyun Wang Fan Xiao Jingyi Li Jie Tian Yida Xing Xiaodan Kong Ke Rui Rencai Qin Xiaoxia Zhu Jing Wang Cainan Luo Haijing Wu Yun Zhang Chengping Wen Lan He Dongzhou Liu Hejian Zou Qianjin Lu Lijun Wu Liwei Lu 
supported by funding for Chongqing International Institute for Immunology(2020YJC10);National Natural Science Foundation of China(81901635,82171782,82260326,81971464);Shenzhen Science and Technology Program(CYJ20210324114602008);Hong Kong Research Grants Council Theme-Based Research Scheme(T12-703/19 R);the Centre for Oncology and Immunology under the Health@InnoHK Initiative by the Innovation and Technology Commission,Hong Kong,China.
Autoantibodies produced by B cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). However, both the cellular source of antiphospholipid antibodies and their contributions to the develop...
关键词：B1 cell Anti-phosphatidylserine antibodies Lupus nephritis TLR SYK 
Apoptotic vesicles ameliorate lupus and arthritis via phosphatidylserine-mediated modulation of T cell receptor signaling被引量：3
《Bioactive Materials》2023年第7期472-484,共13页Runci Wang Meng Hao Xiaoxing Kou Bingdong Sui Maria Laura Sanmillan Xiao Zhang Dawei Liu Jun Tian Wenjing Yu Chider Chen Ruili Yang Lingyun Sun Yi Liu Claudio Giraudo Deepak A.Rao Nan Shen Songtao Shi 
This work was supported by grants from the State Scholarship Fund of China(201506240225to R.W.);the Pearl River Talent Recruitment Program(2019ZT08Y485,2019QN01Y138,2019JC01Y182);the National Key R&D Program of China(2021YFA1100600to S.S.);the Guangdong Financial Fund for High-Caliber Hospital Construction(174-2018-XMZC-0001-03-0125,D-07 to S.S.,C-03 and D-11 to X.K.);the National Natural Science Foundation of China(82170924to X.K.).
Mesenchymal stem cells(MSCs)influence T cells in health,disease and therapy through messengers of intercellular communication including extracellular vesicles(EVs).Apoptosis is a mode of cell death that tends to promo...
关键词：AUTOIMMUNITY T cell MSC Apoptosis Extracellular vesicles 
Efficient secretory expression of phospholipase D for the high-yield production of phosphatidylserine and phospholipid derivates from soybean lecithin被引量：2
《Synthetic and Systems Biotechnology》2023年第2期273-280,共8页Peng Zhang Jin-Song Gong Zhi-Hao Xie Chang Su Xiao-Mei Zhang Zhi-Ming Rao Zheng-Hong Xu Jin-Song Shi 
supported by the National Key Research and Development Program of China(No.2021YFC2100900);the National Natural Science Foundation of China(No.32171261);the Natural Science Foundation of Jiangsu Province(No.BK20221082);the Fundamental Research Funds for the Central Universities(No.JUSRP21940).
Phospholipase D(PLD)is an essential biocatalyst for the biological production of phosphatidylserine and phospholipid modification.However,the efficient heterologous expression of PLD is limited by its cell toxicity.In...
关键词：Phospholipase D Secretion expression Bacillus subtilis BIOSYNTHESIS Enzymatic PLs modification 
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