PHOSPHOSERINE

作品数：7被引量：12H指数：2
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相关领域：生物学医药卫生更多>>
相关期刊：《International Journal of Oral Science》《Synthetic and Systems Biotechnology》《Frontiers of Chemical Science and Engineering》《Regenerative Biomaterials》更多>>
相关基金：国家自然科学基金更多>>
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Engineering and finetuning expression of SerC for balanced metabolic flux in vitamin B6 production
《Synthetic and Systems Biotechnology》2024年第2期388-398,共11页Kai Chen Linxia Liu Jinlong Li Zhizhong Tian Hongxing Jin Dawei Zhang 
This work was supported by the National Key R&D Program of China(2022YFC2106100);National Natural Science Foundation of China(22178372,32200049);National Science Fund for Distinguished Young Scholars(22325807);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIP-KJGG-011,TSBICIP-CXRC-055);Yellow River Delta Industry Leading Talents(DYRC20190212).
Vitamin B6 plays a crucial role in cellular metabolism and stress response,making it an essential component for growth in all known organisms.However,achieving efficient biosynthesis of vitamin B6 faces the challenge ...
关键词：Vitamin B6 Phosphoserine aminotransferase SerC Protein engineering Multifunctional enzymes Metabolic flux distribution 
A mix & act liposomes of phospholipase A2-phosphatidylserine for acute brain detoxification by blood‒brain barrier selective-opening被引量：1
《Acta Pharmaceutica Sinica B》2024年第4期1827-1844,共18页Zinan Zhang Wenbin Cao Huanchun Xing Shuai Guo Lijuan Huang Lin Wang Xin Sui Kui Lu Yuan Luo Yongan Wang Jun Yang 
In the treatment of central nervous system disease,the blood-brain barrier(BBB)is a major obstruction to drug delivery that must be overcome.In this study,we propose a brain-targeted delivery strat-egy based on select...
关键词：Liposomes Phospholipase A2 PHOSPHOSERINE Blood-brainbarrier Selectively open Mix&act 
Customized synthesis of phosphoprotein bearing phosphoserine or its nonhydrolyzable analog
《Synthetic and Systems Biotechnology》2023年第1期69-78,共10页Dong Liu Yingying Liu Hua-Zhen Duan Xinjie Chen Yanan Wang Ting Wang Qing Yu Yong-Xiang Chen Yuan Lu 
supported by the National Natural Science Foundation of China (21878173,22177059);National Key R&D Program of China (2018YFA0901700,2021YFC2103900);a grant from the Institute Guo Qiang,Tsinghua University (2021GQG1016).
Studies on the mechanism of protein phosphorylation and therapeutic interventions of its related molecular processes are limited by the difficulty in the production of purpose-built phosphoproteins harboring site-spec...
关键词：Cell-free synthetic biology PHOSPHOPROTEIN PHOSPHORYLATION Orthogonal translation system Nonhydrolyzable analog 
Phosphoserine enhanced Cu-doped bioactive glass dynamic dual-network hydrogel for craniofacial bone defect repair被引量：3
《Regenerative Biomaterials》2023年第1期1135-1148,共14页Yuwei Liu Gang Wang Huitong Luo Bangjiao Zhao Muheng Liao Qiyuan Dai Maocai Li Qingtao Li Xiaodong Cao 
supported by the Fundamental Research Funds for the Central Universities(grant number 2022ZYGXZR105);the National Natural Science Foundation of China(grant numbers 52272276,52073103,52203164);the Zhongshan Innovation Project of high-end Scientific Research Institutions(grant number 2020AG020)。
Flexible hydrogels containing various osteogenic inorganic constituents,which can accommodate complicated shape variations,are considered as ideal grafts for craniofacial bone defect reconstruction.However,in most hyb...
关键词：Cu-doped bioactive glass PHOSPHOSERINE dynamic hydrogel craniofacial bone defect 
Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3β/β-catenin in urinary bladder cancer patients被引量：2
《World Journal of Clinical Oncology》2019年第4期166-182,共17页Niharika Maurya Rinni Singh Apul Goel Atin Singhai Uday Pratap Singh Vinita Agrawal Minal Garg 
BACKGROUND Aberrant activation of phosphorylated form of glycogen synthase kinase-3β[pS9 GSK-3β(Serine 9 phosphorylation)] is known to trigger Wnt/β-catenin signal cascade but its clinicohistopathological implicati...
关键词：PATHOBIOLOGY Target genes Tumor stage and grade Wnt/β–catenin signal cascade UROTHELIAL carcinoma of BLADDER 
The importance of a potential phosphorylation site in enamelin on enamel formation被引量：2
《International Journal of Oral Science》2017年第4期210-215,共6页Wen-Juan Yan Pan Ma Ye Tian Jing-Ya Wang Chun-Lin Qin Jian Q Feng Xiao-Fang Wang 
supported by NIH grant DE026461;start funding of Texas A&M University College of Dentistry
Enamelin （ENAM） has three putative phosphoserines （pSers） phosphorylated by a Golgi-associated secretory pathway kinase （FAM20C） based on their distinctive Ser-x-Glu （S-x-E） motifs. Fam2OC-knockout mice show s...
关键词：AMELOBLASTIN ENAMEL ENAMELIN FAM20C PHOSPHORYLATION PHOSPHOSERINE 
Enzyme-instructed self-assembly of peptides containing phosphoserine to form supramolecular hydrogels as potential soft biomaterials被引量：4
《Frontiers of Chemical Science and Engineering》2017年第4期509-515,共7页
Enzyme-instructed self-assembly （EISA） offers a facile approach to explore the supramolecular assemblies of small molecules in cellular milieu for a variety of biomedical applications. One of the commonly used enzym...
关键词：enzyme-instructed self-assembly phosphoser-ine PHOSPHATASE supramolecular hydrogel 
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