PHOSPHATASE

作品数：260被引量：894H指数：14
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相关机构：中国科学院遗传与发育生物学研究所山东大学湖北中医药大学安徽中医学院第一附属医院更多>>
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Long noncoding RNA GAS5 acts as a competitive endogenous RNA to regulate GSK-3β and PTEN expression by sponging miR-23b-3p in Alzheimer's disease
《Neural Regeneration Research》2026年第1期392-405,共14页Li Zeng Kaiyue Zhao Jianghong Liu Mimin Liu Zhongdi Cai Ting Sun Zhuorong Li Rui Liu 
supported by the National Natural Science Foundation of China,Nos. 82173806 and U1803281;Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science,Nos. 2021-I2M-1-030 and 2022-I2M-2-002;Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences,No. 2022-JKCS-08 (all to RL)。
Long noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer's disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated. The lon...
关键词：Alzheimer's disease amyloid-beta peptide accumulation cognitive dysfunction competitive endogenous RNA glycogen synthase kinase 3beta lncRNA growth arrest-specific 5 microRNA-23b-3p neuronal apoptosis phosphatase and tensin homologue deleted on chromosome 10 tau phosphorylation 
miRNA dysregulation in Duchenne muscular dystrophy comorbidities
《World Journal of Experimental Medicine》2025年第2期142-149,共8页Subhashree Sivakumar Archana Rajavel Venkataraman Viswanathan Evangeline Ann Daniel Prakash Gangadaran Raja Natesan Sella 
BACKGROUND Duchenne muscular dystrophy(DMD)is a neuromuscular disorder caused by mutations in the dystrophin gene.DMD is reported to coexist with other comorbidities,although the occurrence of the triad,autism spectru...
关键词：Duchenne muscular dystrophy DYSTROPHIN MIRNA Autism spectrum disorder Phosphatase and tensin Inflammatory response 
Apatinib regulates the glycolysis of vascular endothelial cells through PI3K/AKT/PFKFB3 pathway in hepatocellular carcinoma
《World Journal of Gastroenterology》2025年第11期135-152,共18页Yi Wu Bin-Bin Xie Bing-Liang Zhang Qing-Xin Zhuang Shi-Wei Liu Hong-Ming Pan 
Supported by the National Natural Science Foundation of China,No.82100542 and No.81802842.
BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent and aggressive malignancy in the Chinese population;the severe vascularization by the tumor makes it difficult to cure.The high incidence and poor survival rates ...
关键词：Apatinib Hepatocellular carcinoma Vascular endothelial cells GLYCOLYSIS Phosphatidylinositol 3-kinase Protein kinase B 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase 3 
Loss of phosphatase and tensin homolog(PTEN)increases Lysyl oxidase-like 2(LOXL2)expression enhancing the growth of fallopian tube epithelial cells as three-dimensional spheroids
《Cancer Pathogenesis and Therapy》2025年第1期68-75,共8页Angela Russo Junlone Moy Manead Khin Timothy R.Dorsey Alfredo Lopez Carrero Joanna E.Burdette 
was supported by the National Institutes of Health(NIH)funding programs R01(Nos:CA240301 and CA240423);the Rivkin Pilot Study Award(No.572533),which constituted a crucial resource for conducting our study.
Background:High-grade serous ovarian cancer(HGSOC)accounts for 70-80%of all ovarian cancer-related deaths.Multiple studies have suggested that the fallopian tube epithelium(FTE)serves as the cell of origin of HGSOC.Ph...
关键词：LOXL2 PTEN PAX2 Fallopian tube Ovarian cancer 
G6PC3 is involved in spermatogenesis by maintaining meiotic sex chromosome inactivation
《Acta Biochimica et Biophysica Sinica》2025年第2期286-294,共9页Yuming Cao Shengnan Wang Liyang Li Wenwen Li Yan Liang Fei Ao Zexiao Wei Li Wang 
supported by the grants from the National Natural Science Foundation of China(No.82301804);the China Postdoctoral Science Foundation(No.2023M734014).
Meiosis,a process unique to germ cells,involves formation and repair of double-stranded nicks in DNA,pairing and segregation of homologous chromosomes,which ultimately achieves recombination of homologous chromosomes....
关键词：glucose 6 phosphatase catalytic 3(G6PC3) SPERMATOGENESIS sex chromosomes pachytene arrest meiotic sex chromosome inactivation 
Engineering cellular dephosphorylation boosts(+)-borneol production in yeast
《Acta Pharmaceutica Sinica B》2025年第2期1171-1182,共12页Haiyan Zhang Peng Cai Juan Guo Jiaoqi Gao Linfeng Xie Ping Su Xiaoxin Zhai Baolong Jin Guanghong Cui Yongjin J.Zhou Luqi Huang 
supported by National Key R&D Program of China(2020YFA0908000);the CACMS Innovation Fund(CI2021A04109,CI2023D002,China);Key project at central government level:the ability to establish sustainable use of valuable Chinese Medicine Resources(2060302,China).
(+)-Borneol,the main component of"Natural Borneol"in the Chinese Pharmacopoeia,is a high-end spice and precious medicine.Plant extraction cannot meet the increasing demand for(+)-borneol,while microbial biosynthesis o...
关键词：BORNEOL MONOTERPENE LPP1 DPP1 Nudix hydrolase PHOSPHATASE 
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A
《Acta Pharmacologica Sinica》2025年第1期107-121,共15页Tong Zhao Zhi-ruo Zhou Hui-qi Wan Tian Feng Xu-hui Hu Xiao-qian Li Shi-mei Zhao Hong-lin Li Ji-wei Houl Wei Li Da-yun Lu Min-yi Qian Xu Shen 
This work was supported by the National Natural Science Foundation of China(82273930);the Jiangsu Provincial Natural Science Foundation Project(BK20240747);the National Natural Science Foundation for Young Scientists of China(82204486,82304468 and 82304494);the Natural Science Foundation for Young Scientists of Nanjing University of Chinese Medicine(XPT82204486 and XPT82304468);Major Programof the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(24KJA310006,23KJA350002);Jiangsu Key Discipline Construction Fund of the 14th Five-Year Plan(Biology)and"Qing Lan"project.Graph abstract was drawn by Figdraw.
Pulmonary fibrosis(PF)is a chronic,progressive and irreversible interstitial lung disease characterized by unremitting pulmonary myofibroblasts activation,extracellular matrix(ECM)deposition and inflammatory recruitme...
关键词：pulmonary fibrosis PPM1A otilonium bromide NLRP3 SMAD3 
Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease
《Neural Regeneration Research》2025年第1期199-200,共2页Srishti Chawla Mikael Molin Thomas Nystrom 
Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and mammals.Its biological functions range from ion homeostas...
关键词：ACTIVATION DINUCLEAR CONSERVED 
Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula:Evidence,mechanisms and perspective
《World Journal of Hepatology》2024年第10期1208-1212,共5页Nabil Eid Payal Bhatnagar Li-Li Chan Marina Garcia-Macia 
In this letter,we comment on a recent publication by Mei et al,in the World Journal of Hepatology,investigating the hepatoprotective effects of the modified Xiaoyao San(MXS)formula in a male rat model of non-alcoholic...
关键词：STEATOSIS Liver Xiaoyao San Inflammation ANDROGEN Adenosine 5’-monophosphate-activated protein kinase Phosphatase and tensin homolog Autophagy Lipophagy Alpha smooth muscle actin 
Long noncoding RNA steroid receptor RNA activator 1 inhibits proliferation and glycolysis of esophageal squamous cell carcinoma
《World Journal of Gastrointestinal Oncology》2024年第10期4194-4208,共15页Ming He Ye Qi Ze-Mao Zheng Min Sha Xiang Zhao Yu-Rao Chen Zheng-Hai Chen Rong-Yu Qian Juan Yao Zheng-Dong Yang 
Supported by Innovative Team of Jiangsu Province,No.CXTDA2017042;Jiangsu Provincial Medical Youth Talent,No.QNRC2016508;In-Hospital Project of Taizhou People's Hospital,No.ZL201930.
BACKGROUND The clinical effects and detailed roles of long non-coding RNA(LncRNA)steroid receptor RNA activator 1(SRA1)in esophageal squamous cell carcinoma(ESCC)remain ambiguous.In the present study,the complementary...
关键词：Steroid receptor RNA activator 1 Esophageal squamous cell carcinoma Phospholysine phosphohistidine inorganic pyrophosphate phosphatase Cancer therapy MicroRNA Long non-coding RNA 
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