Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease  

作　　者：Srishti Chawla Mikael Molin Thomas Nystrom 

机构地区：[1]Institute for Biomedicine,Sahlgrenska Academy,Centre for Ageing and Health-AgeCap,University of Gothenburg,Gothenburg,Sweden [2]Department of Life Sciences,Chalmers University of Technology,Gothenburg,Sweden

出　　处：《Neural Regeneration Research》2025年第1期199-200,共2页中国神经再生研究（英文版）

摘　　要：Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and mammals.Its biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated T-cells.CN is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate Cna1p.The calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关 键 词：ACTIVATION DINUCLEAR CONSERVED 

分 类 号：R742.5[医药卫生—神经病学与精神病学]