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Transcription factors,metabolic dysfunction-associated fatty liver disease,and therapeutic implications: 《Genes & Diseases》2025年第3期137-145,共9页Shuwei Hu Yingjie Ai Chencheng Hu Fathima N.Cassim Bawa Yanyong Xu; supported by the National Natural Science Foundation of China(No.32271218 to Y.X.).; Metabolic dysfunction-associated fatty liver disease(MAFLD)encompasses a spectrum of liver diseases ranging from metabolic dysfunction-associated fatty liver to metabolic dysfunction-associated steatohepatitis,which m...; 关键词：Apoptosis FIBROSIS Inflammation MAFLD STEATOSIS Transcription factors

Bioinformatics-based Prediction of Schaftoside Remission in Liver Disease with Cholestasis and Steatosis: 《Medicinal Plant》2025年第2期55-57,61,共4页Yueping ZHI Kefeng ZHANG Ya GAO Bo LI Houkang CAO; Supported by Qingmiao Talent Funding Research Project of Guangxi Province;National College Student Innovation and Entrepreneurship Training Program(202310601031).; [Objectives]To explore the target and mechanism of Schaftoside on cholestasis and steatosis based on network pharmacology and molecular docking.[Methods]The targets of"cholestasis"and"steatosis"were predicted using da...; 关键词：CHOLESTASIS STEATOSIS Schaftoside

Hepatic-specific vitamin D receptor downregulation alleviates agingrelated metabolic dysfunction-associated steatotic liver disease: 《World Journal of Gastroenterology》2025年第14期118-141,共24页Feng Zhu Bing-Ru Lin Shi-Hua Lin Chao-Hui Yu Yun-Mei Yang; Supported by the National Natural Science Foundation of China,No.820300089.; BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is defined by the abnormal lipid deposition in hepatocytes.The prevalence of MASLD is significantly increased in the elderly population,suggest...; 关键词：Aging Metabolic dysfunction-associated steatotic liver disease Vitamin D receptor STEATOSIS HEPATOCYTES

Impact of donor obesity on paediatric liver transplantation;current evidence and potentials for graft pool expansion: 《World Journal of Transplantation》2025年第3期70-78,共9页Amr Alnagar Ahmed Amgad Tassos Grammatikopoulos Eirini Kyrana; Paediatric liver transplantation(PLT)is a life-saving procedure for children with advanced liver disease or hepatoblastoma.The number of available grafts is limited in relation to the number of children on PLT waiting...; 关键词：Paediatric liver transplantation OBESITY Graft pool STEATOSIS Graft failure

Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders: 《Acta Pharmaceutica Sinica B》2025年第2期892-908,共17页Yangliu Xia Yang Zhang Zhipeng Zhang Nana Yan Vorthon Sawaswong Lulu Sun Wanwan Guo Ping Wang Kristopher W.Krausz Oksana Gavrilova James M.Ntambi Haiping Hao Tingting Yan Frank J.Gonzalez; supported by the National Cancer Institute Intramural Research Program,CCR,CIL,the Natural Science Foundation of Jiangsu Province(BK20241592,China)to Tingting Yan;National Natural Science Foundation of China(No.82404732 to Tingting Yan,No.81930109 and 82321005 to Haiping Hao,No.82370848 and HY2022-7 to Lulu Sun,No.62173005 to Zhipeng Zhang);the Project of State Key Laboratory of Natural Medicines,China Pharmaceutical University(SKLNMZZ202402 to Haiping Hao,China);National Institutes of Health,National Institute of Diabetes and Digestive and Kidney Diseases(DK118093 to James N.Ntambi,USA);supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development(NICHD,USA).; Stearoyl-coenzyme A desaturase 1(SCD1)catalyzes the rate-limiting step of de novo lipogenesis and modulates lipid homeostasis.Although numerous SCD1 inhibitors were tested for treating metabolic disorders both in prec...; 关键词：OBESITY SCD1 MT1 Intestinal epithelium High-fat diet Oxidative stress STEATOSIS Metabolic disorders

Prospects of elafibranor in treating alcohol-associated liver diseases: 《World Journal of Gastroenterology》2025年第2期132-137,共6页Wei-Tong Cui Hua-Ru Xue Dian-Fang Wei Xiao-Yu Feng Kai Wang; Supported by Natural Science Foundation of Shandong Province,China,No.ZR2019PC053;the Projects of Medical and Health Technology Development Program in Shandong Province,China,No.202202020837 and No.202301040472.; Alcohol-related liver disease(ALD),which is induced by excessive alcohol con-sumption,is a leading cause of liver-related morbidity and mortality.ALD pa-tients exhibit a spectrum of liver injuries,including hepatic st...; 关键词：Elafibranor Alcohol-associated liver diseases Peroxisome proliferator-activated receptor LIPID Apoptosis STEATOSIS Inflammation FIBROSIS

Association between intra-pancreatic fat deposition and diseases of the exocrine pancreas: A narrative review: 《World Journal of Gastroenterology》2025年第2期27-41,共15页Jing Ye Jian-Guo Wang Rong-Qiang Liu Qiao Shi Wei-Xing Wang; Supported by National Natural Science Foundation of China,No.82170651;and the Research Support Fund of Hubei Microcirculation Society,No.HBWXH2024(1)-1.; Intrapancreatic fat deposition(IPFD)has garnered increasing attention in recent years.The prevalence of IPFD is relatively high and associated with factors such as obesity,age,and sex.However,the pathophysiological me...; 关键词：Intrapancreatic fat deposition Pancreatic steatosis Nonalcoholic fatty pancreas disease PANCREATITIS Pancreatic cancer

Effect of alpha-lipoic acid and Silybum marianum supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis: 《World Journal of Hepatology》2025年第1期86-95,共10页Ana D Cano Contreras María Del Rocío Francisco Jose L Vargas Basurto Kevin D Gonzalez-Gomez Mercedes Amieva-Balmori Federico Roesch Dietlen JoséM Remes-Troche; BACKGROUND The treatment of metabolic dysfunction-associated steatotic liver disease(MA-SLD)has focused on the control of comorbidities.Silybum marianum(SM)and alpha-lipoic acid(ALA)have shown antioxidant and adjuvant...; 关键词：Steatotic liver disease Silybum marianum Alpha-lipoic acid Mediterranean diet Fatty liver

Ultrasound Pulse Elastometry: Assessment of One Year’s Practice in the Hepato-Gastroenterology Department of the Saint Camille Hospital in Ouagadougou: 《Open Journal of Gastroenterology》2024年第11期379-385,共7页Kounpiélimé Sosthène Somda Lawagoulé Joseph Emile Ky Constant Lawrence Coudjo Johnson Stella Line Emmanuella Paré Ben Moctar Abdou Djibo Toussaint Vébamba Abraham Ouédraogo Fanta Ousseini Mamadou Sarifou Diallo Sandrine M. O. B. Héma/Soudré Aboubacar Coulibaly Arsène Roger Sombié; Aims: To review one year of ultrasound impulse elastometry in a hospital in Ouagadougou. Patients and Method: This is a retrospective descriptive study of data from one year’s use of impulse ultrasound elastometry. U...; 关键词：Pulse Elastometry Hepatic Fibrosis STEATOSIS Non-Invasive Evaluation of Fibrosis Africa

Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula:Evidence,mechanisms and perspective: 《World Journal of Hepatology》2024年第10期1208-1212,共5页Nabil Eid Payal Bhatnagar Li-Li Chan Marina Garcia-Macia; In this letter,we comment on a recent publication by Mei et al,in the World Journal of Hepatology,investigating the hepatoprotective effects of the modified Xiaoyao San(MXS)formula in a male rat model of non-alcoholic...; 关键词：STEATOSIS Liver Xiaoyao San Inflammation ANDROGEN Adenosine 5’-monophosphate-activated protein kinase Phosphatase and tensin homolog Autophagy Lipophagy Alpha smooth muscle actin

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