HEPATOCYTES

作品数：335被引量：1478H指数：18
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相关作者：阚全程李晶晶田志刚李金鸣常天辉更多>>
相关机构：郑州大学第一附属医院中国医科大学中国科学院中国科学技术大学更多>>
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Dietary administration of probiotic Bacillus coagulans and Mentha piperita can protect histological architecture and DNA damage in Catla catla(Hamilton,1822)
《Aquaculture and Fisheries》2024年第6期948-956,共9页Sonal Saluja Anita Bhatnagar 
sincerely thankful to HSCST-JRF(HSCST-2301)for fellowship.
The present experimental investigation was executed to evaluate the combined effect of probiotic bacterium Bacillus coagulans along with herb Mentha piperita on histological architecture;and extent of DNA damage after...
关键词：Bacillus COMET HEPATOCYTES HISTOLOGICAL MENTHA 
Vitamin D 1,25-Dihydroxyvitamin D_(3) reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization被引量：1
《World Journal of Gastrointestinal Oncology》2024年第12期4685-4699,共15页Wen-Jing Luo Xian-Wen Dong Hua Ye Qiao-Su Zhao Qiu-Bo Zhang Wen-Ying Guo Hui-Wei Liu Feng Xu 
Supported by the Natural Science Foundation of Ningbo,No.202003N4234;and Medical and Health Research Project of Zhejiang Province,No.2024KY1477.
BACKGROUND Non-alcoholic fatty liver disease(NAFLD),which is a significant liver condition associated with metabolic syndrome,is the leading cause of liver diseases globally and its prevalence is on the rise in most n...
关键词：Non-alcoholic fatty liver disease HEPATOCYTES MACROPHAGES Polarization Vitamin D receptor Peroxisome proliferator activated receptorγ 
Serum Iron Overload Triggers the SMAD Pathway and Induces Hepcidin Expression in Hepatocytes through SMURF1
《Journal of Clinical and Translational Hepatology》2024年第9期761-762,共2页Taha Yazal Chia-Yang Li 
supported by grants from the National Science and Technology Council,Taiwan,R.O.C.(grant No.NSTC 113-2314-B-037-128 and NSTC 112-2926-I-037-501-G,);Kaohsiung Medical University(grant No.KT113P010).
Dear Editors,In the article“Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1”,Ning Zhang et al.studied the molecular mechanisms linking serum iron overload to hepcidin...
关键词：SERUM SMAD 
Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3
《Chinese Medical Journal》2024年第11期1351-1359,共9页Jiacheng Li Ruopu Li Xue Bai Wenlong Zhang Yu Nie Shengshou Hu 
National Key Research and Development Program of China(No.2019YFA0801500);National High Level Hospital Clinical Research Funding(No.2023-GSP-ZD-2-01);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2021-I2M-1-008)
Background:The ability to generate functional hepatocytes without relying on donor liver organs holds significant therapeutic promise in the fields of regenerative medicine and potential liver disease treatments.Clust...
关键词：Liver fibrosis CRISPRa Cell reprogramming Transcriptional activation HEPATOCYTES 
RAMP1 Protects Hepatocytes against Ischemia-reperfusion Injury by Inhibiting the ERK/YAP Pathway
《Journal of Clinical and Translational Hepatology》2024年第4期357-370,共14页Yongsheng Tang Zenan Yuan Xu Lu Yingqiu Song Shuguang Zhu Chunhui Qiu Qi zhang Binsheng Fu Changchang Jia Hua Li 
supported by:The National Natural Science Foundation of China(82270688,81402426);The Natural Science Foundation.of Guangdong Province(2021A1515010726,2022A1515012650,2020A1515010302);The Cultivation Project of National Natural Science Foundationof the Third Affliated Hospital of Sun Yat-sen University(No.2020GzRPYMS09);Science and Technology ProjectsinGuangzhou(No.202102010310,202201020427).
Background and Aims:Hepatic ischemia-reperfusion injury(HIRI)is a prevalent complication of liver transplantation,partial hepatectomy,and severe infection,necessitating the development of more effective clinical strat...
关键词：Hepatic ischemia-reperfusion injury(HIRI) Receptor activity-modifying protein 1(RAMP1) YES-Associated Protein(YAP) Extracellular signalregulated kinase(ERK) 
Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1被引量：1
《Journal of Clinical and Translational Hepatology》2024年第3期227-235,共9页Ning Zhang Pengyao Yang Yanmeng Li Qin Ouyang Fei Hou Guixin Zhu Bei Zhang Jian Huang Jidong Jia Anjian Xu 
supported by the National Natural Science Foundation of China(No.82370898);Beijing Natural Science Foundation(No.7202034).
Background and Aims:Liver iron overload can induce hepatic expression of bone morphogenic protein(BMP)6 and activate the BMP/SMAD pathway.However,serum iron overload can also activate SMAD but does not induce BMP6 exp...
关键词：BMP/SMAD pathway HEPCIDIN Holo-transferrin Ubiquitin-proteasome degradation HEMOCHROMATOSIS 
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
《Signal Transduction and Targeted Therapy》2024年第3期1199-1208,共10页Xinyi Yang Xu Zheng Yuqi Zhu Xiaying Zhao Jun Liu Jiangna Xun Songhua Yuan Jun Chen Hanyu Pan Jinlong Yang Jing Wang Zhimin Liang Xiaoting Shen Yue Liang Qinru Lin Huitong Liang Min Li Fei Peng Daru Lu Jianqing Xu Hongzhou Lu Shibo Jiang Ping Zhao Huanzhang Zhu 
supported by the National Natural Science Foundation of China(82041001,31771484,81761128020,92169112)。
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes multi-organ damage,which includes hepatic dysfunction,as observed in over 50%of COVID-19 patients.Angiotensin I converting enzyme(peptidyl-dipeptidase ...
关键词：ACE2 INFECTION GLYCOPROTEIN 
Long-term functional maintenance of primary hepatocytes in vitro using macroporous hydrogels engineered through liquid-liquid phase separation
《Nano Research》2024年第3期1725-1736,共12页Yang Sun Sheng Yin Jian Cui Zhongxia Wang Yueying Han Ding Ma Shuo Wang Junhua Wu Yi Cao Chunping Jiang Xiaosong Gu 
funded by the National Key R&D Program of China(No.2020YFA0908100);the Research Project of Jinan Microecological Biomedicine Shandong Laboratory(Nos.JNL2022004A,JNL2022019B);Shandong Provincial Laboratory Project(No.SYS202202).
Preserving the functionality of hepatocytes in vitro poses a significant challenge in liver tissue engineering and bioartificial liver,as these cells rapidly lose their metabolic and functional characteristics after i...
关键词：liver tissue engineering phase separation HEPATOCYTES macroporous hydrogel 
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes被引量：9
《Protein & Cell》2024年第2期98-120,共23页Shanshan Yang Chengyu Liu Mengmeng Jiang Xiaoqian Liu Lingling Geng Yiyuan Zhang Shuhui Sun Kang Wang jian Yin Shuai Ma Si Wang Juan Carlos Izpisua Belmonte Weiqi Zhang Jing Qu Guang-Hui Liu 
supported by the National Key Research and Development Program of China (Grant Nos.2022YFA1103700,2020YFA0804000,2020YFA0112200,2021YFF1201000,2022YFA1103800,2021YFA1101401,the STI2030-Major Projects-2021ZD0202400);the National Natural Science Foundation of China (Grant Nos.92049116,81921006,82125011,92149301,92168201,91949209,92049304,32121001,82192863,82122024,82071588,32000500,82271600);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16000000);CAS Project for Young Scientists in Basic Research (YSBR-076,YSBR-012);the Program of the Beijing Natural Science Foundation (Z190019);the Pilot Project for Public Welfare Development and Reform of Beijing-affiliated Medical Research Institutes (No.11000022T000000461062);Youth Innovation Promotion Association of CAS (E1CAZW0401,2023092,2022083);Young Elite Scientists Sponsorship Program by CAST (YESS20200012,YESS20210002);the Informatization Plan of Chinese Academy of Sciences (CAS-WX2021SF-0301,CAS-WX2022SDC-XK14,CAS-WX2021SF-0101);New Cormerstone Science Foundation through the XPLORER PRIZE (2021-1045);Excellent Young Talents Program of Capital Medical University (No.12300927);Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team (BPHR202203105).
Aging increases the risk ofliver diseases and systemic susceptibility to aging-related diseases.However,cell type-specific changes and the underlying mechanism of liver aging in higher vertebrates remain incompletely ...
关键词：single-nucleus RNA sequencing LIVER HEPATOCYTES AGING SENESCENCE SREBP2 
Milk fat globule epidermal growth factor 8 alleviates liver injury in severe acute pancreatitis by restoring autophagy flux and inhibiting ferroptosis in hepatocytes
《World Journal of Gastroenterology》2024年第7期728-741,共14页Qing Cui Hang-Cheng Liu Wu-Ming Liu Feng Ma Yi Lv Jian-Cang Ma Rong-Qian Wu Yi-Fan Ren 
Supported by the National Natural Science Foundation of China,No.82100685;the Scientific Research Fund of Xi’an Health Commission,No.2021yb08;Scientific Research Fund of Xi’an Central Hospital,No.2022QN07;Innovation Capability Support Plan of Xi’an Science and Technology Bureau,No.23YXYJ0097.
BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ...
关键词：Autophagy flux Ferroptosis Liver injury Milk fat globule epidermal growth factor 8 αvβ3/5 integrins Acute pancreatitis 
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