HEPATOCYTES

作品数：338被引量：1481H指数：18
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相关机构：郑州大学第一附属医院中国医科大学中国科学院中国科学技术大学更多>>
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EGFR-mediated crosstalk between vascularendothelial cells and hepatocytes promotesPiezo1-dependent liver regeneration
《Genes & Diseases》2025年第3期411-427,共17页Yuelei Hu Guifang Du Chao Li Rui Wang Juan Liu Yunfang Wang Jiahong Dong 
supported by the National Key Research and Development Program of China(No.2022YFA1103400);the CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5e056);the National Natural Science Foundation of China(No.81930119,92168207,32371477,82090051);the Precision Medicine Research Program of Tsinghua University(No.10001020612);the National High Level Hospital Clinical Research Funding(China)(No.2022-NHLHCRF-LX-03-0102).
Hepatocyte proliferation is essential for recovering liver function after injury. Inliver surgery, the mechanical stimulation induced by hemodynamic changes triggers vascularendothelial cells (VECs) to secrete large a...
关键词：EGFR Hemodynamic changes Liver regeneration Piezo1 Vascular endothelial cells 
Delaying liver aging:Analysis of structural and functional alterations
《World Journal of Gastroenterology》2025年第15期1-7,共7页Yu-Qin Yao Qiong-Yue Cao Zheng Li 
Supported by the National Natural Science Foundation of China,No.82104525;Open Foundation of Key Laboratory of Tropical Plant Resource Chemistry of Hainan Province,No.rdzw2024s01.
This article is based on a recent bibliometric analysis of research progress on liver aging.The liver is notable for its extraordinary ability to rejuvenate,thereby safeguarding and maintaining the organism’s integri...
关键词：Liver aging TELOMERE HEPATOCYTES Caloric restriction Physical exercise REGENERATION 
Hepatic-specific vitamin D receptor downregulation alleviates agingrelated metabolic dysfunction-associated steatotic liver disease
《World Journal of Gastroenterology》2025年第14期118-141,共24页Feng Zhu Bing-Ru Lin Shi-Hua Lin Chao-Hui Yu Yun-Mei Yang 
Supported by the National Natural Science Foundation of China,No.820300089.
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is defined by the abnormal lipid deposition in hepatocytes.The prevalence of MASLD is significantly increased in the elderly population,suggest...
关键词：Aging Metabolic dysfunction-associated steatotic liver disease Vitamin D receptor STEATOSIS HEPATOCYTES 
Dietary administration of probiotic Bacillus coagulans and Mentha piperita can protect histological architecture and DNA damage in Catla catla(Hamilton,1822)
《Aquaculture and Fisheries》2024年第6期948-956,共9页Sonal Saluja Anita Bhatnagar 
sincerely thankful to HSCST-JRF(HSCST-2301)for fellowship.
The present experimental investigation was executed to evaluate the combined effect of probiotic bacterium Bacillus coagulans along with herb Mentha piperita on histological architecture;and extent of DNA damage after...
关键词：Bacillus COMET HEPATOCYTES HISTOLOGICAL MENTHA 
Vitamin D 1,25-Dihydroxyvitamin D_(3) reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization被引量：1
《World Journal of Gastrointestinal Oncology》2024年第12期4685-4699,共15页Wen-Jing Luo Xian-Wen Dong Hua Ye Qiao-Su Zhao Qiu-Bo Zhang Wen-Ying Guo Hui-Wei Liu Feng Xu 
Supported by the Natural Science Foundation of Ningbo,No.202003N4234;and Medical and Health Research Project of Zhejiang Province,No.2024KY1477.
BACKGROUND Non-alcoholic fatty liver disease(NAFLD),which is a significant liver condition associated with metabolic syndrome,is the leading cause of liver diseases globally and its prevalence is on the rise in most n...
关键词：Non-alcoholic fatty liver disease HEPATOCYTES MACROPHAGES Polarization Vitamin D receptor Peroxisome proliferator activated receptorγ 
Serum Iron Overload Triggers the SMAD Pathway and Induces Hepcidin Expression in Hepatocytes through SMURF1
《Journal of Clinical and Translational Hepatology》2024年第9期761-762,共2页Taha Yazal Chia-Yang Li 
supported by grants from the National Science and Technology Council,Taiwan,R.O.C.(grant No.NSTC 113-2314-B-037-128 and NSTC 112-2926-I-037-501-G,);Kaohsiung Medical University(grant No.KT113P010).
Dear Editors,In the article“Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1”,Ning Zhang et al.studied the molecular mechanisms linking serum iron overload to hepcidin...
关键词：SERUM SMAD 
Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3
《Chinese Medical Journal》2024年第11期1351-1359,共9页Jiacheng Li Ruopu Li Xue Bai Wenlong Zhang Yu Nie Shengshou Hu 
National Key Research and Development Program of China(No.2019YFA0801500);National High Level Hospital Clinical Research Funding(No.2023-GSP-ZD-2-01);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2021-I2M-1-008)
Background:The ability to generate functional hepatocytes without relying on donor liver organs holds significant therapeutic promise in the fields of regenerative medicine and potential liver disease treatments.Clust...
关键词：Liver fibrosis CRISPRa Cell reprogramming Transcriptional activation HEPATOCYTES 
RAMP1 Protects Hepatocytes against Ischemia-reperfusion Injury by Inhibiting the ERK/YAP Pathway
《Journal of Clinical and Translational Hepatology》2024年第4期357-370,共14页Yongsheng Tang Zenan Yuan Xu Lu Yingqiu Song Shuguang Zhu Chunhui Qiu Qi zhang Binsheng Fu Changchang Jia Hua Li 
supported by:The National Natural Science Foundation of China(82270688,81402426);The Natural Science Foundation.of Guangdong Province(2021A1515010726,2022A1515012650,2020A1515010302);The Cultivation Project of National Natural Science Foundationof the Third Affliated Hospital of Sun Yat-sen University(No.2020GzRPYMS09);Science and Technology ProjectsinGuangzhou(No.202102010310,202201020427).
Background and Aims:Hepatic ischemia-reperfusion injury(HIRI)is a prevalent complication of liver transplantation,partial hepatectomy,and severe infection,necessitating the development of more effective clinical strat...
关键词：Hepatic ischemia-reperfusion injury(HIRI) Receptor activity-modifying protein 1(RAMP1) YES-Associated Protein(YAP) Extracellular signalregulated kinase(ERK) 
Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1被引量：2
《Journal of Clinical and Translational Hepatology》2024年第3期227-235,共9页Ning Zhang Pengyao Yang Yanmeng Li Qin Ouyang Fei Hou Guixin Zhu Bei Zhang Jian Huang Jidong Jia Anjian Xu 
supported by the National Natural Science Foundation of China(No.82370898);Beijing Natural Science Foundation(No.7202034).
Background and Aims:Liver iron overload can induce hepatic expression of bone morphogenic protein(BMP)6 and activate the BMP/SMAD pathway.However,serum iron overload can also activate SMAD but does not induce BMP6 exp...
关键词：BMP/SMAD pathway HEPCIDIN Holo-transferrin Ubiquitin-proteasome degradation HEMOCHROMATOSIS 
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
《Signal Transduction and Targeted Therapy》2024年第3期1199-1208,共10页Xinyi Yang Xu Zheng Yuqi Zhu Xiaying Zhao Jun Liu Jiangna Xun Songhua Yuan Jun Chen Hanyu Pan Jinlong Yang Jing Wang Zhimin Liang Xiaoting Shen Yue Liang Qinru Lin Huitong Liang Min Li Fei Peng Daru Lu Jianqing Xu Hongzhou Lu Shibo Jiang Ping Zhao Huanzhang Zhu 
supported by the National Natural Science Foundation of China(82041001,31771484,81761128020,92169112)。
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes multi-organ damage,which includes hepatic dysfunction,as observed in over 50%of COVID-19 patients.Angiotensin I converting enzyme(peptidyl-dipeptidase ...
关键词：ACE2 INFECTION GLYCOPROTEIN 
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