TELOMERE

作品数：173被引量：419H指数：12
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相关领域：医药卫生生物学更多>>
相关作者：邵宗鸿付蓉许丽艳梁英锐吴名耀更多>>
相关机构：空军军医大学（第四军医大学）空军军医大学天津医科大学总医院苏州大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金湖北省自然科学基金更多>>
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Telomeres: The Promise of New Cancer Therapies
《American Journal of Molecular Biology》2025年第1期88-96,共9页Ruixian Hou Jonathan J. Darrow 
Telomeres have been a subject of genetic research since the 1930s. They play a crucial role in cancer biology, as they influence both cellular senescence and genomic stability. In cancer cells, dysfunctional telomeres...
关键词：TELOMERE Telomerase Inhibition Cancer Detection Cancer Treatment IMMUNOTHERAPY 
BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation
《World Journal of Gastrointestinal Oncology》2025年第1期214-225,共12页Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-Ju Tang Man Luo Xiao-Wu Zhong Qiang Ma Xiao-Lan Guo 
Supported by the Scientific Research Development Plan Project or the Scientific Research Foundation for Advanced Talents,Affiliated Hospital of North Sichuan Medical College,No.2023MPZK017,No.2023ZD001,No.2023-2ZD002,and No.2023GC009;Science and Technology Support Program of Nanchong,No.22SXQT0001;Youth Medical Innovation Research Project,or Medical Research Project of Sichuan Province,No.Q23047 and No.S23020;Development of a Scientific Research Plan for the Doctoral Scientific Research Foundation of the North Sichuan Medical College,No.CBY22-ZDA03.
BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic agents.Telomeres are DNA-protein complexes located at the te...
关键词：Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins 
A telomere-to-telomere genome assembly of the cultivated peanut
《Molecular Plant》2025年第1期5-8,共4页Xiaobo Wang Ziqi Sun Feiyan Qi Zhiyuan Zhou Pei Du Lei Shi Wenzhao Dong Bingyan Huang Suoyi Han Stefano Pavan Meng Zhang Mengjie Cui Jing Xu Hua Liu Li Qin Zhongxin Zhang Xiaodong Dai Wei Gao Lijuan Miao Ruifang Zhao Juan Wang Mengmeng Wang Chenyang Zhi Yaojun Hu Huanhuan Zhao Linjie Chen Xiaodong Jin Yanhui Sun Zheng Zheng Xinyou Zhang 
supported by the National Key Research and Development Program(2023YFD1202800);the Key Research Project of the Shennong Laboratory(SN01-2022-03);the China Agriculture Research System of MOF and MARA(CARS-13);Key Projects of Henan Province(222301420026);Major Science and Technology Projects of Henan Province(221100110300);the Fund for Distinguished Young Scholars from Henan Academy of Agricultural Sciences(2025ZC13,2023JQ02 and 2024JQ06);the Henan Provincial Agriculture Research System,China(S2012-5).
Dear Editor,Cultivated peanut(peanut in short)(Arachis hypogaea,2n=4x=40,genome type AABB)is a legume crop serving globally as a crucial source of edible oil and protein.Available peanut reference genome sequences obt...
关键词：BREEDING CULTIVAR FIGURE 
Severe COVID-19 and Telomere Shortening: Overview of Roles and Effects
《Journal of Biosciences and Medicines》2024年第12期187-205,共19页Sijie Chen 
The importance of telomeres as special structures at the ends of chromosomes is gradually gaining prominence. They are composed of short, multi-repeated non-transcribed sequences (TTAGGG) and binding proteins, and the...
关键词：TELOMERE COVID-19 SARS-CoV-2 T Cell AGING 
Nanopore ultra-long sequencing and adaptive sampling spur plant complete telomere-totelomere genome assembly
《Molecular Plant》2024年第11期1773-1786,共14页Dongdong Lu Caijuan Liu Wenjun Ji Ruiyan Xia Shanshan Li Yanxia Liu Naixu Liu Yongqi Liu Xing Wang Deng Bosheng Li 
supported by the Key R&D Program of Shandong Province,China(grant no.ZR202211070163);the National Natural Science Foundation of China(grant nos.32170574 and 32200249);the Natural Science Foundation of Shandong Province(grant nos.ZR2023QC026 and ZR2023QC106);the Young Taishan Scholars Program and Yuandu Scholars Program.
The pursuit of complete telomere-to-telomere(T2T)genome assembly in plants,challenged by genomic complexity,has been advanced by Oxford Nanopore Technologies(ONT),which offers ultra-long,realtime sequencing.Despite it...
关键词：complete T2T genome ultra-long sequencing nanopore sequencing adaptive sampling filling gaps 
The complete telomere-to-telomere genome assembly of lettuce
《Plant Communications》2024年第10期8-11,共4页Ke Wang Jingyun Jin Jingxuan Wang Xinrui Wang Jie Sun Dian Meng Xiangfeng Wang Yong Wang Li Guo 
supported by the Key R&D Program of Shandong Province(ZR202211070163);the Natural Science Foundation for Distinguished Young Scholars of Shandong Province(ZR2023JQ010);L.G.is also supported by the Taishan Scholars Program of Shandong Province。
Dear Editor,Lettuce(Lactuca sativa L.)is an annual plant of the Asteraceae family,commonly used as a fresh-cut vegetable and a primary ingredient in salads.It is rich in vitamins,minerals,polyphenols,and carotenoids,p...
关键词：LET VITAMIN BENEFITS 
The pineapple reference genome:Telomere-to-telomere assembly, manually curated annotation, and comparative analysis
《Journal of Integrative Plant Biology》2024年第10期2208-2225,共18页Junting Feng Wei Zhang Chengjie Chen Yinlong Liang Tangxiu Li Ya Wu Hui Liu Jing Wu Wenqiu Lin Jiawei Li Yehua He Junhu He Aiping Luan 
supported by National Natural Science Foundation of China(32272677);National Key R&D Program of China(2019YFD1001104);Central Publicinterest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences(1630032024026,1630032024001,1630052023011);Hainan Provincial Natural Science Foundation of China(323QN279)。
Pineapple is the third most crucial tropical fruit worldwide and available in five varieties.Genomes of different pineapple varieties have been released to date;however,none of them are complete,with all exhibiting su...
关键词：PINEAPPLE reference genome MYB transcription factor genome database 
Detection of an 8p23.1 Inversion Using High-Resolution Optical Genome Mapping
《Maternal-Fetal Medicine》2024年第3期173-177,共5页Chunxiang Zhou Huijun Li Yiyan Shi Linlin He Honglei Duan Jie Li 
supported by funding for Clinical Trials from the Affiliated Drum Tower Hospital,Medical School of Nanjing University(2022-LCYJ-MS-06).
Objective:To evaluate the performance of optical genomemapping(OGM)in identifying an inversion located in the short armof chromosome 8(8p,8p23.1),flanked by regions of complex segmental duplication(SD),using the GRCh3...
关键词：Genome mapping Telomere-to-Telomere reference Segmental duplication 8p23.1 inversion 
Telomere-to-telomere genome assemblies of cultivated and wild soybean provide insights into evolution and domestication under structural variation被引量：1
《Plant Communications》2024年第8期92-95,共4页Kai-Hua Jia Xiaoyan Zhang Lei-Lei Li Tian-Le Shi Dan Liu Yongyi Yang Yunzhe Cong Runfang Li Yanyan Pu Yongchao Gong Xue Chen Yu-Jun Si Rumei Tian Zhenya Qian Hanfeng Ding Nana Li 
supported by the Natural Science Foundation of Shandong Province for Young Scholars(ZR2023QC153);the Key R&D Program of Shandong Province(2021LZGC025,2022LZGC022,and 2023LZGC001);the National Natural Science Foundation of China(32201736);the Agricultural Science and Technology Innovation Project of SAAS(CXGC2023F13 and CXGC2023C02)。
Dear Editor,Soybean(Glycine max)is a critical crop worldwide,renowned as a major source of edible oil and protein.It was domesticated approximately 5000-9000 years ago in China,between latitudes 32°N and 40°N,from i...
关键词：soybean INSIGHT EVOLUTION 
Insights into dammarane-type triterpenoid saponin biosynthesis from the telomere-totelomere genome of Gynostemma pentaphyllum
《Plant Communications》2024年第8期100-103,共4页Lingling Yun Chuyi Zhang Tongtong Liang Yu Tian Guoxu Ma Vincent Courdavault Sijie Sun Baiping Ma Ziqin Li Rucan Li Feng Cao Xiaofeng Shen Jianhe Wei Ying Li Baolin Guo Chao Sun 
supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(grant 2021-I2M-1-032).The funders had no role in the design of the study;the collection,analyses,or interpretation of data;the writing of the manuscript;or the decision to publish the results.
Dear Editor,Gynostemma pentaphyllum(Thunb.)Makino,a perennial climbing vine in the Cucurbitaceae family,has been widely used in traditional medicine for over 600 years(Blumert and Liu,1999).It serves as a valuable nat...
关键词：protective GYNOSTEMMA SAPONINS 
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