Delaying liver aging:Analysis of structural and functional alterations  

作　　者：Yu-Qin Yao Qiong-Yue Cao Zheng Li 

机构地区：[1]College of Health Sciences,School of Life Sciences,Jiangsu Normal University,Xuzhou 221000,Jiangsu Province,China

出　　处：《World Journal of Gastroenterology》2025年第15期1-7,共7页世界胃肠病学杂志(英文)

基　　金：Supported by the National Natural Science Foundation of China,No.82104525;Open Foundation of Key Laboratory of Tropical Plant Resource Chemistry of Hainan Province,No.rdzw2024s01.

摘　　要：This article is based on a recent bibliometric analysis of research progress on liver aging.The liver is notable for its extraordinary ability to rejuvenate,thereby safeguarding and maintaining the organism’s integrity.With advancing age,there is a noteworthy reduction in both the liver’s size and blood circulation.Furthermore,the wide range of physiological alterations driven on by aging may foster the development of illnesses.Previous studies indicate that liver aging is linked to impaired lipid metabolism and abnormal gene expression associated with chronic inflammation.Factors such as mitochondrial dysfunction and telomere shortening accumulate,which may result in increased hepatic steatosis,which impacts liver regeneration,metabolism,and other functions.Knowing the structural and functional changes could help elderly adults delay liver aging.Increasing public awareness of anti-aging interventions is essential.Besides the use of dietary supplements,alterations in lifestyle,including changes in dietary habits and physical exercise routines,are the most efficacious means to decelerate the aging process of the liver.This article highlights recent advances in the mechanism research of liver aging and summarizes the promising intervention options to delay liver aging for preventing related diseases.

关 键 词：Liver aging TELOMERE HEPATOCYTES Caloric restriction Physical exercise REGENERATION 

分 类 号：R575[医药卫生—消化系统]