supported by the Nature Science Foundation of Liaoning Province,Nos.2022-MS-211,2021-MS-064,and 2024-MS-048(all to YC).
Alzheimer’s disease,a devastating neurodegenerative disorder,is characterized by progressive cognitive decline,primarily due to amyloid-beta protein deposition and tau protein phosphorylation.Effectively reducing the...
supported in part by research grants from the Key Project of the National Key R&D Plan“Research on Prevention and Control of Major Chronic Non-Communicable Diseases”(China);the Ministry of Science and Technology of the People’s Republic of China,and the National Key R&D Program of China(No.2018YFC1313000,2018YFC1313004).
The pathogenesis of neuroblastoma with bone or bone marrow metastasis (NB-BBM)and its complex immune microenvironment remain poorly elucidated, hampering the advancement of effective risk prediction for BBM and limiti...
Background:Whole-tissue autologous therapeutic vaccines(WATVs)are a form of cancer immunotherapy that use a patient's own pathological tissue.Concerns exist regarding the potential of WATVs to induce autoimmunity or t...
Lung cancer is a common cause of cancer-related death globally.The majority of lung cancer patients initially benefit from chemotherapy and immunotherapy.However,as the treatment cycle progresses and the disease evolv...
The prevalence of intrahepatic cholangiocarcinoma(ICC)is increasing globally.Despite advancements in comprehending this intricate malignancy and formulating novel therapeutic approaches over the past few decades,the p...
supported by Jiangsu Province“333”Project(BRA2020380).
Background:Breast cancer is a prevalent malignant tumor affecting females,with treatment options including surgery,radiotherapy,chemotherapy,and endocrine therapy.Methods:This review synthesizes existing literature on...
supported by the National Natural Science Foundation of China (No.32322020,32170676,31970646,32060152);the Natural Science Foundation of Heilongjiang Province,China (Key Program,No.ZD2023C007);Heilongjiang Touyan Innovation Team Program (China);the specific research fund of The Innovation Platform for Academicians of Hainan Province,China;the project supported by Hainan Province Clinical Medical Center (China).
Hepatocellular carcinoma(HCC)is one of the most common tumors with high prevalence and death rate,which lacks effective targeting and immunotherapy currently.Metabolic reprogramming,which provides an inherent advantag...
Supported by the Health Industry Research Program of Gansu Province,No.GSWSKY2021-043;the Youth Science and Technology Foundation of Gansu Province,No.22JR11RA002;the Natural Science Foundation of Gansu Province,No.22JR5RA008.
BACKGROUND The treatment of gastric cancer remains highly challenging,particularly in cases of unresectable locally advanced or metastatic disease.Although chemotherapy and immunotherapy have shown some efficacy in su...
Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related mortality worldwide.A substantial proportion of patients are diagnosed with advanced or intermediate-advanced stage disease at presentation a...
Pancreatic cancer remains one of the most challenging malignancies to treat,with a poor prognosis and limited therapeutic options.Despite the success of immunotherapy and targeted therapies for other cancers,these app...