SORAFENIB

作品数：318被引量：1563H指数：18
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相关领域：医药卫生更多>>
相关作者：曾普华郜文辉刘霞孙惠川汤钊猷更多>>
相关机构：湖南中医药大学福建医科大学中山大学复旦大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金广东省自然科学基金国家重点基础研究发展计划更多>>
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Immune therapies in intermediate-advanced unresectable hepatocellular carcinoma: Changing the therapeutic landscape
《World Journal of Gastroenterology》2025年第14期1-5,共5页Sagnik Biswas Arghya Samanta 
Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related mortality worldwide.A substantial proportion of patients are diagnosed with advanced or intermediate-advanced stage disease at presentation a...
关键词：Intermediate-advanced stage hepatocellular carcinoma IMMUNOTHERAPY Tyrosine kinase inhibitors SORAFENIB 
Cerbera odollam fruit extracts enhance anti-cancer activity of sorafenib in HCT116 and HepG2 cells
《Chinese Herbal Medicines》2025年第1期108-126,共19页Supawadee Parhira Orakot Simanurak Khemmachat Pansooksan Julintorn Somran Apirath Wangteeraprasert Zhihong Jiang Liping Bai Pranee Nangngam Dumrongsak Pekthong Piyarat Srisawang 
supported by the National Science Research and Innovation Fund(NSRF)of Thailand(No.R2566B047);the Agricultural Research Development Agency(Public Organization),Thailand(No.CRP6505030030);the Global and Frontier Research University Fund,Naresuan University,Thailand(No.R2567C003);the Science and Technology Development Fund,Macao SAR[No.006/2023/SKL(MUST)]。
Objective:While higher therapeutic doses of toxic cardiac glycosides derived from Cerbera odollam are frequently employed in cases of suicide or homicide,ongoing research is investigating the potential anticancer prop...
关键词：apoptosis Cerberaodollam Gaertn. HCT116 HEPG2 reactive oxygen species SORAFENIB 
Efficacy of sorafenib combined with transarterial chemoembolization in the treatment of advanced hepatocellular carcinoma:A metaanalysis
《World Journal of Gastrointestinal Oncology》2025年第2期272-283,共12页Mei Xu Si-Rui Zhou Ya-Ling Li Chen-Hao Zhang Da-Zhong Liao Xiao-Li Wang 
Supported by Sichuan Science and Technology Program,No.2022YFS0625。
BACKGROUND The combination of sorafenib with transarterial chemoembolization(TACE)is being investigated for its potential to improve outcomes in advanced hepatocellular carcinoma(HCC).AIM To evaluate the efficacy of t...
关键词：SORAFENIB Transarterial chemoembolization Hepatocellular carcinoma Overall survival Progression-free survival META-ANALYSIS 
Five-year complete remission of super-giant hepatocellular carcinoma with hepatectomy followed by sorafenib plus camrelizumab:A case report
《World Journal of Gastrointestinal Surgery》2025年第1期273-281,共9页Xiao-Qin Zheng Li-Bo Sun Wen-Jie Jin Hui Liu Wen-Yan Song Hui Xu Ju-Shan Wu Xiao-Jun Wang Chun-Yan Gou Hui-Guo Ding 
BACKGROUND Cirrhotic patients with super-giant hepatocellular carcinoma(HCC)and portal vein invasion generally have a poor prognosis.This paper presents a patient with super-giant HCC and portal vein invasion,who unde...
关键词：HEPATECTOMY SORAFENIB Camrelizumab Super-giant hepatocellular carcinoma Complete remission Case report 
Advanced hepatocellular carcinoma treatment strategies:Are transarterial approaches leading the way?
《World Journal of Gastrointestinal Oncology》2025年第1期22-27,共6页Stefan Patauner Giovanni Scotton Francesca Notte Antonio Frena 
Hepatocellular carcinoma(HCC)is a leading cause of cancer-related mortality worldwide,with advanced stages posing significant treatment challenges.Al-though hepatic arterial infusion chemotherapy(HAIC)has emerged as a...
关键词：Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Transarterial chemoembolization SORAFENIB Combined therapy 
In silico analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells
《World Journal of Gastroenterology》2025年第3期84-102,共19页Patricia de la Cruz-Ojeda Ester Parras-Martínez Raquel Rey-Pérez Jordi Muntané 
Supported by Instituto de Salud Carlos III(ISCiii),No.PI19/01266 and No.PI22/00857;Consejería de Salud y Familias(Junta de Andalucía),No.PI-0216-2020 and No.PIP-0215-2020;Biomedical Research Network Center for Liver and Digestive Diseases(CIBERehd)founded by the ISCIII and co-financed by European Regional Development Fund“A way to achieve Europe”ERDF.
BACKGROUND Hepatocellular carcinoma(HCC)is the most common subtype of primary liver cancer with varied incidence and epidemiology worldwide.Sorafenib is still a recommended treatment for a large proportion of patients...
关键词：Cell culture Hepatocellular carcinoma Non-coding RNA RNASEQ SORAFENIB 
N6-methyladenosine-modified long non-coding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression
《World Journal of Gastroenterology》2024年第48期5174-5190,共17页Yong Yu Xiang-Hong Lu Jin-Song Mu Jiang-Yun Meng Jiang-Shan Sun Hai-Xu Chen Yang Yan Ke Meng 
Supported by the National Natural Science Foundation of China,No.82271628.
BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent and aggressive tumor.Sorafenib is the first-line treatment for patients with advanced HCC,but resistance to sorafenib has become a significant challenge in this t...
关键词：Hepatocellular carcinoma STEMNESS Sorafenib resistance Long non-coding RNA KIF9-AS1 Short stature homeobox 2 
STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma
《Genes & Diseases》2024年第6期466-481,共16页Ran Ren Yu Chen Yu Zhou Luyao Shen Yang Chen Juan Lei Jingchun Wang Xudong Liu Nan Zhang Dongqin Zhou Huakan Zhao Yongsheng Li 
supported by the Major International (Regional)Joint Research Program of the National Natural Science Foundation of China (No.81920108027);the National Natural Science Foundation of China (No.82273212);Chongqing Postgraduate Research and Innovation Project (China) (No.CYS23130);Chongqing Outstanding Youth Science Foundation (China) (No.cstc2020jcyj-jqX0030);Chongqing Science and Technology Innovation Leading Talent Support Program (China) (No.cstc2021ycjh-bgzxm0073).
Dysregulated calcium(Ca?+)signaling pathways are associated with tumor cell death and drug resistance.In non-excitable cells,such as hepatocellular carcinoma(HcC)cells,the primary pathway for Ca2+influx is through str...
关键词：Ferroptosis Hepatocellular carcinoma SLC7A11 Sorafenib resistance STIM1 
Cancer-associated fibroblasts derived fibronectin extra domain A promotes sorafenib resistance in hepatocellular carcinoma cells by activating SHMT1
《Genes & Diseases》2024年第6期510-524,共15页Yan Dong Yanrong Chen Yijie Wang Xiang Zhao Ruiyang Zi Jie Hao Qiong Ding Haoran Jiang Xuesong Wang Fanghao Lu Houjie Liang Zhihao Wei Jianjun Li 
supported in part by the National Natural Science Foundation of China (No.81672856,82203669,81803028);the General Program of Chongqing Natural Science Foundation (China) (No.cstc2021jcyj-msxmX0687).
Resistance to sorafenib,an effective first-line treatment for advanced hepatocellular carcinoma(HCC),greatly compromised the prognosis of patients.The extracellular matrix is one of the most abundant components of the...
关键词：Cancer-associated fibroblasts Fibronectin extra domain A Hepatocellular carcinoma Serine hydroxymethyl transferase1 Sorafenib resistance 
Nonalcoholic steatohepatitis increases plasma retention of sorafenib-glucuronide in a mouse model by altering hepatocyte hopping
《Acta Pharmaceutica Sinica B》2024年第11期4874-4882,共9页Erica Toth Hui Li Kayla Frost Paxton Sample Joseph Jilek Siennah Greenfield Dahea You Danielle Kozlosky Michael Goedken Mary F.Paine Lauren Aleksunes Nathan Cherrington 
by National Institute of General Medical Sciences grant(GM123643,USA);National Institute of Environmental Health Sciences grants(T32ES007148,ES028668,ES006694,and ES007091,USA).
Hepatocyte hopping is the hepatocyte-to-sinusoid-to-hepatocyte shuttling that increases the efficiency of hepatic elimination of xenobiotics. This phenomenon is mediated via efflux of hepatic metabolites by Mrp3 and r...
关键词：Nonalcoholic steatohepatitis Hepatocytehopping SORAFENIB Sorafenibglucuronide Drug disposition ADME Transport Knockoutmouse 
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